PubMed · Archives of Biochemistry and Biophysics· Sarvenaz Moradi·· 27 天前
肿瘤学：The p.V27A variant of l-asparaginase II minimizes glutaminase activity without compromising anti-leukemic function.
The p.V27A variant of l-asparaginase II minimizes glutaminase activity without compromising anti-leukemic function.
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原文摘录：l-Asparaginase is a fundamental chemotherapeutic agent for acute lymphoblastic leukemia (ALL) that depletes circulating asparagine to induce apoptosis in leukemic blasts. … V27A variant delivers an improved safety profile without compromising therapeutic potency, emerging as
来源：PubMed · Archives of Biochemistry and Biophysics · pubmed.ncbi.nlm.nih.gov