STAT新闻报道，诺华资助的III期HORIZON试验详细结果在美国心脏协会（AHA）科学年会上公布，并同步发表于《新英格兰医学杂志》。试验中pelacarsen大幅降低脂蛋白(a)——约五分之一人群携带的遗传性心血管风险因素——但近五年随访中，随机分配至药物或安慰剂的参与者在心梗、卒中、紧急冠脉血运重建和死亡方面均无差异。
关注理由：详细结果坐实此前top-line阴性信号：大幅降低Lp(a)未转化为心血管事件减少，动摇该研发通路的核心假设，可与NEJM同步发表原文对照核实具体数据。
EMA 于 2025 年 12 月 22 日授予 Sanofi 的 rilzabrutinib（Wayrilz）欧盟上市授权，用于既往治疗无效的成人免疫性血小板减少症（ITP），并发布 Revision 1 的 EPAR。
关注理由：EMA 发布 rilzabrutinib（Wayrilz）欧盟上市授权 EPAR，含 202 名成人 ITP 随机对照试验数据及 12 周无效停药规则，可用于孤儿药治疗路径跟踪。
EMA更新teclistamab（Tecvayli）的EPAR：该药用于复发或难治性多发性骨髓瘤成人患者，2022年8月23日获欧盟条件性上市许可，2026年8月20日因公司提交额外数据转为标准上市许可。
关注理由：该EPAR第11版记录teclistamab由条件性上市许可转为标准许可这一监管证据升级，并汇总其单药及联合daratumumab研究的疗效与安全性数据，便于跟踪多发性骨髓瘤后续监管动作。
EMA通报Merck Sharp & Dohme B.V.因商业原因永久停市止吐药Emend（aprepitant，80 mg与125 mg规格），欧盟/EEA短缺持续，预计2028年5月前在所有国家停市，停市与产品质量缺陷或安全问题无关。
关注理由：该通告确认aprepitant停市源于商业原因而非质量或安全问题，6月龄及以上儿童所需口服混悬剂型无替代品，是化疗支持用药供应需持续跟踪的关键缺口。
原文摘录：This phase I/II trial studies the side effects and the best dose of selumetinib and how well it works in treating or re-treating young patients with low grade glioma that has come back (recurrent) or does not respond to treatment (refractory).
关注理由：这条肿瘤学内容涉及相关临床或研究问题，建议查看原文中的方法与适用范围。
原文摘录：BACKGROUND: The Society of Thoracic Surgeons (STS) has designed and validated risk models to predict long-term survival in patients undergoing lung cancer resection.
关注理由：这条外科与麻醉内容涉及相关临床或研究问题，建议查看原文中的方法与适用范围。
原文摘录：BACKGROUND: Prior analyses of PALLAS (NCT02513394), a phase III trial that randomized patients with stage II-III hormone receptor-positive breast cancer to receive adjuvant palbociclib plus endocrine therapy (ET) or ET alone, did not show benefit of the c … gov, NCT02513394
关注理由：这条肿瘤学内容涉及随机对照研究，建议同时核对纳入人群、主要终点与报告结果。
原文摘录：BACKGROUND: Text message reminders (TMRs) and patient navigation (PN) increase bowel cancer screening uptake. To date, no studies have directly compared these interventions with one another. … TRIAL REGISTRATION: ISRCTN17245519
关注理由：关注肿瘤学时，这项随机对照研究可提供直接比较的证据，主要终点和研究局限需要一起阅读。
原文摘录：PURPOSE: To determine whether trabeculotomy is noninferior to combined trabeculotomy-trabeculectomy (CTT) for primary congenital glaucoma (PCG) with a horizontal corneal diameter (HCD) of 12-14 mm. … 0%) in the CTT
关注理由：这条儿科学内容涉及随机对照研究，值得重点看研究分组、主要终点和实际结果。
原文摘录：BACKGROUND: Gestational diabetes mellitus (GDM) is a common metabolic disorder during pregnancy that significantly affects fetal cardiac development.
关注理由：这篇心血管医学资料有原始研究可供追溯，临床意义还需结合研究人群和结局指标判断。
原文摘录：BACKGROUND: Cardiac surgery-associated acute kidney injury affects approximately one in four adults and is independently associated with perioperative mortality and progression to chronic kidney disease. … Platform designs with biomarker-enriched enrollment could convert the next generation of trials into interpretable tests of kidney protection
关注理由：这条外科与麻醉内容涉及随机对照研究，值得重点看研究分组、主要终点和实际结果。
原文摘录：Influenza is associated with increased thrombotic risk, and its viral RNA (vRNA) can be sensed by pattern-recognition receptor RIG-I, but the function of RIG-I in platelets remains unknown. … Our study is the first to demonstrate that platelets have a functionally active vRNA-sensing RIG-I receptor that finely tunes thrombotic risk and facilitates appropriate leukocyte transmigration during infection, through non-classical platelet activation
关注理由：这篇感染病学资料可用于了解领域进展，研究设计、结果和局限性值得一起阅读。
原文摘录：INTRODUCTION: A landmark study by Gibson and coworkers in 2021 estimated that one in 106 individuals carry a predicted pathogenic COL4A3 or COL4A4 variant, suggesting autosomal dominant Alport syndrome is massively underdiagnosed. … These findings argu
关注理由：如果关注医学研究，这项队列研究可以提供观察性证据，阅读时别忘了混杂因素和随访情况。
原文摘录：BACKGROUND: Undernutrition is the leading driver of tuberculosis worldwide, yet its effect on the lungs of people who complete treatment is not well defined. … Nutritional assessment belo
关注理由：这篇呼吸病学资料涉及队列研究，可从人群选择、随访时间和关联强度理解其发现。
原文摘录：BACKGROUND: Most patients with chronic obstructive pulmonary disease (COPD) do not receive maintenance inhaled therapies in concordance with evidence-based clinical guidelines. … 6), respectively
关注理由：这篇呼吸病学队列研究资料适合了解长期变化，研究对象、随访方式和结局指标建议一起查看。
原文摘录：BACKGROUND: Nearly 40% of new cases of esophageal cancer are diagnosed at stage 4. Esophagectomy may offer a survival benefit in highly selected patients with stage 4 esophageal cancer. … Prospective studies are required to define its role
关注理由：如果希望快速了解医学研究证据全貌，这篇系统综述或荟萃分析有参考价值，异质性和纳入研究质量不能跳过。
原文摘录：OBJECTIVES: To evaluate long-term mortality among sepsis survivors in Catalonia over a 15-year period and to identify factors associated with increased mortality within 2 years after hospital discharge. DESIGN: Retrospective population-based cohort study.
关注理由：这篇感染病学队列研究资料适合了解长期变化，研究对象、随访方式和结局指标建议一起查看。
原文摘录：BACKGROUND: Pumitamig, an investigational bispecific antibody targeting programmed death ligand-1 and vascular endothelial growth factor A, has shown preliminary efficacy across several tumour types.
关注理由：这篇肿瘤学资料涉及临床试验，登记状态、研究阶段和受试人群值得进一步核对。
原文摘录：BACKGROUND: Increasingly, protocols have been developed to optimize obstetric anesthesia care. However, there is a paucity of data on adherence to these guidelines.
关注理由：这篇外科与麻醉队列研究资料适合了解长期变化，研究对象、随访方式和结局指标建议一起查看。
原文摘录：OBJECTIVE: Optimizing second-line therapy for type 2 diabetes remains challenging because of interindividual variability in response. Current treatment selection does not consider personal genetic profiles.
关注理由：这条内分泌与代谢内容涉及随机对照研究，除了结论，还应看看样本量、主要终点和不良事件报告。