PubMed · Blood· Anthony R Sciaudone·· 3 天前精选
感染病学:The Pathogen Recognition Receptor RIG-I is Functional in Platelets and Limits Thrombotic Responses.
The Pathogen Recognition Receptor RIG-I is Functional in Platelets and Limits Thrombotic Responses.
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原文摘录:Influenza is associated with increased thrombotic risk, and its viral RNA (vRNA) can be sensed by pattern-recognition receptor RIG-I, but the function of RIG-I in platelets remains unknown. … Our study is the first to demonstrate that platelets have a functionally active vRNA-sensing RIG-I receptor that finely tunes thrombotic risk and facilitates appropriate leukocyte transmigration during infection, through non-classical platelet activation
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来源:PubMed · Blood · pubmed.ncbi.nlm.nih.gov