medRxiv · 独立预印本· Multerer, K.; Atkinson, P.; Nguyen, B.; Woods, L.; Tanigawa, Y.; Kellis, M.; Munkacsi, A.·· 12 天前
内分泌与代谢：Gene-gene and Gene-Environment Interactions Improve Genetic Risk Predictions for Complex Diseases
Gene-gene and Gene-Environment Interactions Improve Genetic Risk Predictions for Complex Diseases
AI 导读
原文摘录：Polygenic risk scores (PRS) assume additive SNP effects, yet genetic risk also arises from interactions between loci and environmental factors that contribute to broad-sense heritability. … A composite score was predictive over traditional additive PRS and predictive of T2D among individuals whose clinical symptoms fall within normal ranges
来源：medRxiv · 独立预印本 · doi.org