肿瘤学：CRISPR mutagenesis of the MYC locus reveals a druggable ultraconserved RNA element.

原文摘录：Noncoding sequences comprise most of the human genome; however, their functional significance remains largely elusive. Using CRISPR tiling mutagenesis with near-PAMless, high-fidelity SpRY-Cas9, we mapped the fitness landscape of an entire human gene, the