原文摘录：This phase I/II trial studies the side effects and the best dose of selumetinib and how well it works in treating or re-treating young patients with low grade glioma that has come back (recurrent) or does not respond to treatment (refractory).
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原文摘录：BACKGROUND: Prior analyses of PALLAS (NCT02513394), a phase III trial that randomized patients with stage II-III hormone receptor-positive breast cancer to receive adjuvant palbociclib plus endocrine therapy (ET) or ET alone, did not show benefit of the c … gov, NCT02513394
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原文摘录：BACKGROUND: Text message reminders (TMRs) and patient navigation (PN) increase bowel cancer screening uptake. To date, no studies have directly compared these interventions with one another. … TRIAL REGISTRATION: ISRCTN17245519
关注理由：关注肿瘤学时，这项随机对照研究可提供直接比较的证据，主要终点和研究局限需要一起阅读。
原文摘录：Influenza is associated with increased thrombotic risk, and its viral RNA (vRNA) can be sensed by pattern-recognition receptor RIG-I, but the function of RIG-I in platelets remains unknown. … Our study is the first to demonstrate that platelets have a functionally active vRNA-sensing RIG-I receptor that finely tunes thrombotic risk and facilitates appropriate leukocyte transmigration during infection, through non-classical platelet activation
关注理由：这篇感染病学资料可用于了解领域进展，研究设计、结果和局限性值得一起阅读。
原文摘录：OBJECTIVES: To evaluate long-term mortality among sepsis survivors in Catalonia over a 15-year period and to identify factors associated with increased mortality within 2 years after hospital discharge. DESIGN: Retrospective population-based cohort study.
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原文摘录：The Tumaini trial protocol (NCT07842107) developed by the National Institute of Biomedical Research of the Democratic Republic of the Congo and partners to evaluate the efficacy of vaccines against Bundibugyo virus (BDBV) includes pregnant and lactating w
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原文摘录：Among older people living with kidney failure and frailty or multimorbidity, we found no evidence that either preparing for responsive management or preparing for renal dialysis was superior in terms of QALYs over a mean follow-up duration of 4·5 years.
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原文摘录：Clinical guidelines generally favour coronary artery bypass grafting (CABG) over percutaneous coronary intervention (PCI) as the revascularisation strategy of choice in patients with left main coronary artery disease. … 3 The PRECOMBAT trial4 and SYNTAX Extended Survival trial5 similarly demonstrated no significant differences in all-cause mortality at 10 years between patients who underwent PCI with first-generation drug-eluting stents and those who underwent CABG
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原文摘录：One in four adolescents worldwide reported not getting at least 60 minutes of physical activity on any day in the previous week. … Stand with science”, the theme of World Health Day 2026, marks a year-long campaign to highlight science as the foundation for protecting health and well-being worldwide
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原文摘录：BACKGROUND: Fatigue is a common symptom in cancer patients associated with impaired quality of life (QoL). Little is known about long-term fatigue trajectories in prostate cancer (PCa) patients. … PCa patients with elevated pre-radiotherapy fatigue levels and diabetes may require closer monitoring in risk-stratified aftercare programmes
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原文摘录：WHO / Monika Mey Local health workers in Cambodia are trained in surveillance techniques, including stool examination using Kato-Katz, to detect schistosomiasis eggs, identify potential hotspots and support early detection and treatment. … int Related Global report on neglected tropical diseases 2026 Ending the neglect to attain the Sustainable Development Goals: A road map for neglected tropical diseases 2021–2030 WHO's work on neglected tropical diseases More WHO Global Neglected Tropical Diseases Programme
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原文摘录：BACKGROUND: Severe hyperkalemia is a potentially life-threatening emergency, yet data focusing specifically on non-dialysis-dependent patients presenting to the emergency department (ED) with potassium levels ≥7.0 mmol/L remain limited. … These findings support a context-based approach to risk stratification and dialysis decision-making
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原文摘录：BACKGROUND: Alcohol-related hepatitis (AH) has a 30% 90-day mortality. More accurate predictors of mortality and infection are needed to guide patient management. … QFM could be integrated into clinical management pathways as a decision tool to guide treatment options
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原文摘录：See all DONs related to this event Situation at a glance On 20 October 2026, the National IHR Focal Point (NFP) of France notified WHO regarding the first documented human infection with Shamonda virus (SHAV). … item/2026-DON623
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原文摘录：CDRH is issuing this Early Alert to notify the public of a potentially high-risk device issue. The FDA will keep the public informed and update this web page as significant new information becomes available. Affected Product The FDA is aware that B. … Health care professionals and consumers may report adverse reactions or quality problems they experienced using these devices to MedWatch: The FDA Safety Information and Adverse Event Reporting Program
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原文摘录：BACKGROUND: Gestational diabetes mellitus (GDM) is a growing global public health concern, particularly in low- and middle-income countries such as Kenya.
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原文摘录：Image credit: © tadamichi | stock.adobe.com Meeting highlights from the Pharmacovigilance Risk Assessment Committee (PRAC) 26 - 29 October 2026 30 October 2026 PRAC starts review of depression and anxiety medicine Deanxit and a safety signal related to hu … eu All other enquiries please submit your request via the online form Follow us on Bluesky Related medicine information Flupentixol/melitracen-containing medicinal products - referral Topics Pharmacovigilance
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原文摘录：This recall involves removing certain devices from where they are used or sold. The FDA has identified this recall as the most serious type. This device may cause serious injury or death if you continue to use it. … Health care professionals and consumers may report adverse reactions or quality problems they experienced using these devices to MedWatch: The FDA Safety Information and Adverse Event Reporting Program
关注理由：这篇血液病学资料可用于了解领域进展，研究设计、结果和局限性值得一起阅读。
原文摘录：Periprosthetic hip dislocation is a frequent complication after primary total hip arthroplasty. Observational studies suggest that dual mobility cups may reduce dislocation risk to approximately 1%, but definitive randomized evidence supporting their rout
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原文摘录：Background and ObjectivesTo characterize the clinical features and cerebrospinal fluid (CSF) findings of patients exhibiting a type IV oligoclonal band (OCB) pattern, defined by the presence of identical IgG bands in both CSF and serum. … These findings support cautious interpretation of the type IV pattern in routine clinical practice
关注理由：这条神经内科内容值得查看其研究问题与证据来源，具体结论和适用范围以原文为准。