行业资料：Hepatocyte Pparg knockout and restored Bhmt expression reduce liver steatosis in male mice with diet-induced MASH.

原文摘录：Metabolic dysfunction-associated liver disease (MASLD) is characterized by the accumulation of triglycerides in hepatocytes and can progress to metabolic dysfunction-associated steatohepatitis (MASH) with inflammation, hepatocyte ballooning, and fibrosis. … Overall, our results indicate a protective role for BHMT in hepatocytes of mice with MASH, even in mice expressing Pparg in hepatocytes