原文摘录：The purpose of this 1-year open-label extension study is to characterize the longer-term safety and tolerability of DDY391 and to assess the durability of clinical response in participants with Psoriatic Arthritis (PsA) who have completed treatment in the
原文摘录：Non-State actors information and engagement session 7 October 2026 Amid growing mistrust in science and widespread health misinformation, the WHO Civil Society Commission and the WHO Chief Scientist’s Office held an information session for non-State actor … int
原文摘录：Dr Geetha Krishnan Gopalakrishna Pillai of WHO Global Centre for Traditional Medicine, delivering his keynote at FoodMed 2026 Conference The FoodMed Conference returned for its second edition on 5–6 November 2026, bringing together international experts,
原文摘录：Fungicide resistance in multinucleate fungi, such as Rhizoctonia solani, poses a growing challenge for effective disease management. This study explores the molecular mechanisms underlying resistance to the fungicide SYP-14288 in R.
原文摘录：In a subset of repeat expansion disorders, nuclear dysfunction extends beyond the originating locus through poorly understood mechanisms.
原文摘录：OBJECTIVE: Intrasaccular flow disruption (IFD) has been shown to be safe and efficacious in the treatment of unruptured cerebral aneurysms. … CONCLUSIONS: This largest-to-date prospe
原文摘录：Understanding genotype-phenotype correlations is critical for precision medicine, yet patients carrying mutations in the same gene are often classified under one disorder and treated alike, despite potentially opposite responses to therapy.
原文摘录：MOTIVATION: Gene regulatory network (GRN) inference from single-cell transcriptomes is complicated by expression patterns associated with both cell state and shared ancestry.
原文摘录：Divorce is among the most common and costly life disruptions adults may face. Maladaptive and ineffective couple communication is routinely implicated in leading models as the cause of divorce, and interventions designed to prevent divorce accordingly pri
研究者在番茄中开发优化引导编辑系统 TomPE2、TomPE6c 和 TomPE7，精准缺失 SlBs5/SlBs5L 的两个亮氨酸以重建辣椒来源的抗病缺失等位基因，并通过向感病基因 SlDMR6 引入提前终止密码子获得对 Xanthomonas 和 Pseudomonas syringae 的抗性。
原文摘录：The disease burden attributable to climate change and its costs are large and growing.1 Preventing these health and economic losses in line with climate–health goals2 requires scaling up climate–health actions globally.
原文摘录：Six proven climate and health measures could save 1.6 million lives a year while delivering trillions of dollars in economic and fiscal gains, according to a new World Health Organization (WHO) report released today.
关注理由：这条医学资料适合作为深入阅读入口，尤其要关注研究方法与结论是否匹配。
原文摘录：PURPOSE: To evaluate short-term associations between bisphosphonate exposure and uveitis, scleritis, and cystoid macular edema (CME). DESIGN: Nationwide case-case-time-control (CCTC) study. … CONCLUSIONS: Short-term assoc
原文摘录：Organismal physiology depends on continuous, non-hierarchical communication among cells, tissues, and organs. We argue that this communication rests on metabolic flexibility-the capacity of cells and tissues to adapt substrate use to changing energetic de … We propose that signals from the body are not peripheral modifiers of brain function but fundamental determinants of it, with direct implications for hypothalamus-centered strategies to preserve brain health across the lifespan
原文摘录：SUMMARY: We present rustybam, a Rust-based command-line toolkit for CIGAR-aware manipulation of PAF and BAM alignments, and SafFire, a browser-based tool for interactive genome comparison visualization with annotation overlays.
原文摘录：Metabolic dysfunction-associated liver disease (MASLD) is characterized by the accumulation of triglycerides in hepatocytes and can progress to metabolic dysfunction-associated steatohepatitis (MASH) with inflammation, hepatocyte ballooning, and fibrosis. … Overall, our results indicate a protective role for BHMT in hepatocytes of mice with MASH, even in mice expressing Pparg in hepatocytes
原文摘录：Menke-Hennekam syndrome (MKHK) is a neurodevelopmental disease characterized by specific pathogenic regions within the transcriptional coactivator CREB-binding protein (CREBBP).
原文摘录：Driving frequently exposes individuals to conditions triggering acute stress, but its effects on drivers' visual behaviour remain insufficiently understood. … They also indicate that multimodal context-aware validation is needed for translation into real-time driver state monitoring and safety-relevant assistance applications
原文摘录：Managing multidrug-resistant gram-positive infections is challenging, especially when prolonged therapy is needed for conditions like bacteremia, endocarditis, osteomyelitis, or other deep-seated infections.
原文摘录：Global healthcare systems spend trillions of dollars treating inherited diseases. Therapeutic germline gene editing has the potential to fundamentally shift medicine from treatment to prevention by genetically correcting the disease mutation at the embryo
原文摘录：I was medically diagnosed with ME/CFS. After being ill for five years, I fully recovered by retraining my brain. By 'brain training', I mean roughly the repetition of mental exercises with bodily movements that function to rewire neural pathways to improv … I also reflect as a philosopher on why I was not to blame for being ill and address a skeptical social trend that would deny testimony like mine
原文摘录：This article has been withdrawn due to a publisher error that caused the article to be duplicated. The definitive version of this article is published under https://doi.org/10.1093/treephys/tpz110.