呼吸病学：Influenza viruses as vaccine vectors: Historical background and future directions.

原文摘录：Influenza viruses have served as experimental vaccine vectors for more than three decades, combining such advantages as mucosal delivery, segmented reverse genetics and clinically established attenuation strategies. … However, given that influenza B strains in trivalent LAIVs are particularly potent inducers of immune responses, further development of this vector platform could not only overcome the packaging constraints of the influenza genome for foreign inserts but also enable the creation of effective multivalent vaccines against the most epidemiologically relevant respiratory pathogens