机器学习建模UNOS数据库提示肺移植离体时间延长风险存在供体类型特异性
研究者基于UNOS数据库2012–2024年28,120例成年肺移植受者，用Light Gradient Boosting Machine模型结合SHAP量化供体类型、机器灌注与离体（OOB）时间对移植后一年死亡率的影响。
#呼吸系统
PubMed · Journal of Thoracic and Cardiovascular Surgery
PubMed · Infection and Immunity 呼吸病学：Flagellin enhances innate immune responses in human airway epithelium during bacterial infection.
原文摘录：Bacterial pneumonia poses a significant challenge to public health, often leading to antibiotic treatment failure. Enhancing innate immunity represents a promising adjunctive strategy to conventional antibiotic therapy.
PubMed · American Journal of Respiratory and Critical Care Medicine 开发并外部验证预测COPD发生的pre-COPD评分
研究者在Copenhagen General Population Study（N=14,506）开发pre-COPD评分（含吸烟≥10包年、现吸烟、呼吸道症状、哮喘、pre-BD FEV1/FVC 0.70–0.75各1分。
PubMed · CHEST Journal精选 呼吸病学：The Impact of Undernutrition on Post-Tuberculosis Lung-Function: A Prospective Cohort Study.
原文摘录：BACKGROUND: Undernutrition is the leading driver of tuberculosis worldwide, yet its effect on the lungs of people who complete treatment is not well defined. … Nutritional assessment belo
关注理由：这篇呼吸病学资料涉及队列研究，可从人群选择、随访时间和关联强度理解其发现。
PubMed · CHEST Journal精选 呼吸病学：The impact of removing prior authorization for guideline-concordant maintenance inhaled medications for COPD: a population-based cohort study.
原文摘录：BACKGROUND: Most patients with chronic obstructive pulmonary disease (COPD) do not receive maintenance inhaled therapies in concordance with evidence-based clinical guidelines. … 6), respectively
关注理由：这篇呼吸病学队列研究资料适合了解长期变化，研究对象、随访方式和结局指标建议一起查看。
PubMed · The Journal of Infectious Diseases 呼吸病学：Viral Aetiology of Lower Respiratory Tract Infections in Infants Attending Primary Care in Eastern Spain, 2023-2025.
原文摘录：To describe seasonal patterns of respiratory viruses in infants presenting to primary care (PC) after the rollout of the RSV-immunisation programme in Spain, we analysed multiplex RT-PCR results from infants <1 year with lower respiratory tract infections
PubMed · Advanced Drug Delivery Reviews 呼吸病学：Regulatory landscape for inhaled biologics: Considerations and guidelines.
原文摘录：Despite significant scientific interest, only a small number of inhaled biologics have reached regulatory approval, reflecting the complex interplay between the inherent structural fragility of biologics during the aerosolization steps intrinsic to inhale
PubMed · Transplantation 动物与体外研究提示Piezo1介导的钙信号参与肺移植缺血再灌注损伤中的上皮损伤
一项结合公共转录组数据、大鼠肺移植与体外氧糖剥夺/复氧模型的研究提示，机械敏感离子通道Piezo1在肺缺血/再灌注损伤（IRI）后上调，伴随肺上皮细胞凋亡、钙超载和线粒体膜电位去极化。Piezo1沉默或抑制可减轻钙积累、减少凋亡信号并改善细胞活力，而Yoda1激活可部分恢复损伤表型。结果提示Piezo1可能是肺移植IRI上皮损伤的潜在调控靶点，但仍属临床前证据。
PubMed · SLEEP 上海睡眠健康研究队列发表阻塞性睡眠呼吸暂停睡眠参数与心脏自主神经关联图谱观察研究
基于上海睡眠健康研究队列9,359名受试者的整夜多导睡眠图数据，研究者用三阶段降维将147项睡眠参数和68项心率变异性（HRV）指标压缩为59项参数和25项指标，并以校正多变量线性回归逐对评估关联。
FDA · MedWatch Safety Alerts精选 FDA早期预警：Compact Medical移除部分批次ButterflyBVM球囊面罩复苏器并更新使用说明
FDA CDRH发布早期预警，通报潜在高风险器械问题：Compact Medical对部分批次ButterflyBVM一次性球囊面罩（BVM）复苏器发出紧急医疗器械召回通知，建议移除000109–000117批次，000081–000108批次须每次使用前完成使用前测试。
关注理由：FDA CDRH以Early Alert标记该潜在高风险器械问题，区分需移除批次与仅需使用前测试的批次，可据此跟踪急救通气器械的受影响范围与后续监管更新。
PubMed · Clinical Microbiology Reviews 综述：肺结核与慢性肺曲霉病的鉴别诊断挑战及资源有限环境下的潜在解决方案
作者在Clinical Microbiology Reviews发表叙述性综述，讨论有分枝杆菌病史或现症患者中慢性肺曲霉病（CPA，多由烟曲霉引起）与肺结核复发、非结核分枝杆菌（NTM）感染等鉴别困难及误诊后果。
Europe PMC · 独立预印本 呼吸病学：A respiratory microdomain links ubiquinone biosynthesis to succinate dehydrogenase in an apicomplexan mitochondrion lacking Complex I
原文摘录：Mitochondrial complex I (CI) is a major entry point for NADH-derived electrons and an important site of redox regulation in most eukaryotes. … gondii , defining a previously unrecognized organization of mitochondrial respiration in an organism lacking CI
PubMed · SLEEP 睡眠呼吸暂停呼吸自相似性内表型与心血管病发生率及CVD相关死亡率的关联研究（SHHS与MESA二次分析）
对睡眠心脏健康研究（SHHS）和多族裔动脉粥样硬化研究（MESA）的二次分析显示，以呼吸自相似性（SS%）和CREI评估的睡眠期间呼吸环路增益内表型，其最高四分位与新发心血管疾病相关（MESA HR 1.693。
FDA · MedWatch Safety Alerts精选 呼吸病学：Early Alert: Medline Removes or Corrects All Medline Brand Beds and Accessories
原文摘录：CDRH is issuing this Early Alert to notify the public of a potentially high-risk device issue. The FDA will keep the public informed and update this web page as significant new information becomes available. … Health care professionals and consumers may report adverse reactions or quality problems they experienced using these devices to MedWatch: The FDA Safety Information and Adverse Event Reporting Program
关注理由：这条呼吸病学内容涉及相关临床或研究问题，建议查看原文中的方法与适用范围。
medRxiv · 独立预印本 呼吸病学：A Unified Flexible Large Polysomnography Model for Sleep Staging and Downstream Clinical Screening
原文摘录：Polysomnography (PSG) is central to sleep medicine, yet its analysis remains hindered by labor-intensive manual scoring and limited cross-center generalizability.
FDA · MedWatch Safety Alerts精选 呼吸病学：Update: Import Alert for Certain Olympus Medical Devices Manufactured in Japan - Letter to Health Care Providers
原文摘录：October 20, 2026 The U.S. Food and Drug Administration (FDA) is alerting health care providers about an import alert for certain medical devices manufactured in Japan by Olympus Medical Systems Corporation (Olympus) and its subsidiaries. … Additional Resources Import Alert 89-04 [10/19/2026] FDA Issues Two Warning Letters to Leading Manufacturer of Endoscopes [01/10/2023] Warning Letters Olympus Medical Systems Corporation Warning Letter [10/07/2026] Olympus Medical Systems Corporation Warning Letter (Hinode) [03/15/2023] Olympus Medical Systems Corporation Warning Letter (Hachioji-shi) [12/12/2022] Aizu Olympus Warning Letter [11/02/2022] Infections Associated with Reprocessed Duodenoscopes [06/30/2022] Infections Associated with Reprocessed Urological Endoscopes - Letter to Health Care Providers [04/01/2021]
关注理由：这条呼吸病学内容涉及相关临床或研究问题，建议查看原文中的方法与适用范围。
PubMed · Virology 呼吸病学：Influenza viruses as vaccine vectors: Historical background and future directions.
原文摘录：Influenza viruses have served as experimental vaccine vectors for more than three decades, combining such advantages as mucosal delivery, segmented reverse genetics and clinically established attenuation strategies. … However, given that influenza B strains in trivalent LAIVs are particularly potent inducers of immune responses, further development of this vector platform could not only overcome the packaging constraints of the influenza genome for foreign inserts but also enable the creation of effective multivalent vaccines against the most epidemiologically relevant respiratory pathogens
PubMed · Medicine & Science in Sports & Exercise COVID-19住院幸存者队列横断面分析：体力活动水平与肺-肾功能异常的关联
一项对653名COVID-19住院幸存者（46%女性，28%≥65岁）出院后8±2个月的前瞻性队列横断面分析显示，53%存在体力缺乏活动（<150分钟/周）。