动物研究:Sugen/缺氧大鼠重度肺动脉高压模型的右心房与右心室重塑特征分析
一项动物研究在6周龄雄性Wistar大鼠中以Sugen/缺氧(SuHx)诱导肺动脉高压(PH),经导管测压确认右心压力超负荷,并用共聚焦显微镜、micro-CT、光学标测和蛋白质组质谱分析右心房与右心室重塑。
一项动物研究在6周龄雄性Wistar大鼠中以Sugen/缺氧(SuHx)诱导肺动脉高压(PH),经导管测压确认右心压力超负荷,并用共聚焦显微镜、micro-CT、光学标测和蛋白质组质谱分析右心房与右心室重塑。
原文摘录:Bacterial pneumonia poses a significant challenge to public health, often leading to antibiotic treatment failure. Enhancing innate immunity represents a promising adjunctive strategy to conventional antibiotic therapy.
研究者在Copenhagen General Population Study(N=14,506)开发pre-COPD评分(含吸烟≥10包年、现吸烟、呼吸道症状、哮喘、pre-BD FEV1/FVC 0.70–0.75各1分。
原文摘录:BACKGROUND: Undernutrition is the leading driver of tuberculosis worldwide, yet its effect on the lungs of people who complete treatment is not well defined. … Nutritional assessment belo
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原文摘录:BACKGROUND: Most patients with chronic obstructive pulmonary disease (COPD) do not receive maintenance inhaled therapies in concordance with evidence-based clinical guidelines. … 6), respectively
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原文摘录:To describe seasonal patterns of respiratory viruses in infants presenting to primary care (PC) after the rollout of the RSV-immunisation programme in Spain, we analysed multiplex RT-PCR results from infants <1 year with lower respiratory tract infections
原文摘录:Despite significant scientific interest, only a small number of inhaled biologics have reached regulatory approval, reflecting the complex interplay between the inherent structural fragility of biologics during the aerosolization steps intrinsic to inhale
基于上海睡眠健康研究队列9,359名受试者的整夜多导睡眠图数据,研究者用三阶段降维将147项睡眠参数和68项心率变异性(HRV)指标压缩为59项参数和25项指标,并以校正多变量线性回归逐对评估关联。
原文摘录:Mitochondrial complex I (CI) is a major entry point for NADH-derived electrons and an important site of redox regulation in most eukaryotes. … gondii , defining a previously unrecognized organization of mitochondrial respiration in an organism lacking CI
原文摘录:CDRH is issuing this Early Alert to notify the public of a potentially high-risk device issue. The FDA will keep the public informed and update this web page as significant new information becomes available. … Health care professionals and consumers may report adverse reactions or quality problems they experienced using these devices to MedWatch: The FDA Safety Information and Adverse Event Reporting Program
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原文摘录:Polysomnography (PSG) is central to sleep medicine, yet its analysis remains hindered by labor-intensive manual scoring and limited cross-center generalizability.
原文摘录:October 20, 2026 The U.S. Food and Drug Administration (FDA) is alerting health care providers about an import alert for certain medical devices manufactured in Japan by Olympus Medical Systems Corporation (Olympus) and its subsidiaries. … Additional Resources Import Alert 89-04 [10/19/2026] FDA Issues Two Warning Letters to Leading Manufacturer of Endoscopes [01/10/2023] Warning Letters Olympus Medical Systems Corporation Warning Letter [10/07/2026] Olympus Medical Systems Corporation Warning Letter (Hinode) [03/15/2023] Olympus Medical Systems Corporation Warning Letter (Hachioji-shi) [12/12/2022] Aizu Olympus Warning Letter [11/02/2022] Infections Associated with Reprocessed Duodenoscopes [06/30/2022] Infections Associated with Reprocessed Urological Endoscopes - Letter to Health Care Providers [04/01/2021]
关注理由:这条呼吸病学内容涉及相关临床或研究问题,建议查看原文中的方法与适用范围。
原文摘录:Influenza viruses have served as experimental vaccine vectors for more than three decades, combining such advantages as mucosal delivery, segmented reverse genetics and clinically established attenuation strategies. … However, given that influenza B strains in trivalent LAIVs are particularly potent inducers of immune responses, further development of this vector platform could not only overcome the packaging constraints of the influenza genome for foreign inserts but also enable the creation of effective multivalent vaccines against the most epidemiologically relevant respiratory pathogens