原文摘录：See all DONs related to this event Read more about Yellow fever Situation at a glance Yellow fever transmission continues in the WHO African Region, with recent outbreak activity concentrated in parts of West Africa. … item/2026-DON624
原文摘录：Comirnaty RSS Authorised This medicine is authorised for use in the European Union COVID-19 mRNA vaccine Medicine Human Authorised Rolling review Application under evaluation CHMP opinion European Commission decision Overview Comirnaty is a vaccine for pr … 5-containing Covid-19 mRNA vaccines in the Nordic countries - post-authorisation study A Non-Interventional Post-Authorization Safety Study (PASS) for Active Safety Surveillance of Recipients of the Pfizer-BioNTech COVID-19 mRNA vaccine in the EU - post-authorisation study Real-world effectiveness of different COVID-19 vaccines in Spain: a cohort study based on public electronic health records (BIFAP) (effectiveness of COVID-19 vaccines in Spain) - post-authorisation study This page was last updated on 06/11/2026
原文摘录：Entyvio RSS Authorised This medicine is authorised for use in the European Union vedolizumab Medicine Human Authorised Application under evaluation CHMP opinion European Commission decision Overview Entyvio is a medicine used to treat adult patients with … 73 KB - PDF) First published: 21/03/2014 Last updated: 21/03/2014 View News on Entyvio Meeting highlights from the Committee for Medicinal Products for Human Use (CHMP) 13-16 December 2021 17/12/2021 Meeting highlights from the Committee for Medicinal Products for Human Use (CHMP) 24-27 February 2020 28/02/2020 European Medicines Agency recommends 39 medicines for human use for marketing authorisation in first half of 2014 10/07/2014 Meeting highlights from the Committee for Medicinal Products for Human Use (CHMP) 17-20 March 2014 21/03/2014 European Medicines Agency recommends approval of a locally targeted treatment for ulcerative colitis and Crohn's disease 21/03/2014 More information on Entyvio EMEA-000645-PIP03-18 - paediatric investigation plan EMEA-000645-PIP01-09-M09 - paediatric investigation plan EMEA-000645-PIP04-20-M02 - paediatric investigation plan Vedolizumab-4081: Infection Outcomes among Advanced Therapy-naive Older Adult US Patients With UC/CD Initiating ENTYVIO, TNF-alpha Inhibitors, or Ustekinumab: A Retrospective Observational Matched-Cohort Study Using Medicare Claims Data, 2016-2025 - post-authorisation study Vedolizumab-5001: Organization of Teratology Information Specialists (OTIS) Vedolizumab Pregnancy Exposure Registry - post-authorisation study Vedolizumab-5056: Clinical Effectiveness of Vedolizumab Used in Frames of Drug Program for Crohn’s Disease Treatment in Poland – Prospective, Observational Study Considering Fatigue and Other Patient-reported-outcomes (PROs) (POLONEZ II) - post-authorisation study Comparative Effectiveness of Tofacitinib Versus Ustekinumab and Vedolizumab among Ulcerative Colitis Patients With Prior Anti- Tumor Necrosis Factor (TNF) Failure - post-authorisation study Topics Medicines This page was last updated on 06/11/2026
Clinical Microbiology Reviews发表综述，系统梳理针对碳青霉烯酶产酶肠杆菌目（CPE，涉及KPC、OXA-48-like、NDM、VIM、IMP等A、B、D类酶）的新型β-内酰胺类及β-内酰胺/β-内酰胺酶抑制剂复方。内容涵盖头孢地尔及含青霉烷砜、重氮双环辛烷和环状硼酸类抑制剂复方的结构与机制特征、体外抗菌活性及新发耐药机制，以指导临床定位和新药开发。
原文摘录：Potyviruses constitute the largest known group of plant RNA viruses. Their 6K2 protein is an integral membrane protein that induces the formation of vesicular structures, which support viral RNA replication and act as vehicles for intracellular movement.
原文摘录：The increasing demand for sustainable food packaging technologies has stimulated the development of biomass-derived active materials capable of simultaneously reducing agricultural waste and extending food shelf life.
临床前研究显示，编码嵌合（cHA）与马赛克（mHA）血凝素的自扩增mRNA（samRNA）疫苗经初免-加强免疫后，组1疫苗（cH8/1-cH5/1）诱导广谱交叉反应抗体，对覆盖数十年抗原漂移的多种H1N1株完全保护；组2疫苗（cH4/3-cH15/3、mH10/3-mH14/3）对多种H3N2株及异亚型H7N9攻击提供类似广度，cHA samRNA跨组保护更优。
研究者利用公开数据分析美国佛罗里达州1996–2025年汉森病（麻风）流行趋势，期间共报告359例确诊病例，年发病率从0.01/10万升至0.15/10万，增长15倍。2023年美国共报告225例新病例，佛州为主要报告州之一；Brevard县以113例成为确诊病例热点，在已知感染来源的病例中本地获得性感染占比最大。
观点文章指出，麻风联合化疗（MDT）虽可实现微生物学治愈，但不能逆转已建立的神经损伤，也不能消除未来眼部并发症风险；兔眼、角膜感觉减退、暴露性角膜病变、葡萄膜炎等可在诊断时、治疗中或治疗结束后长期出现。作者建议将治疗中眼部评估与治疗完成后的风险分层随访、明确转诊责任、支持性自我照护及视力结局常规记录相衔接，并整合入现有麻风、初级保健和眼科服务体系。
原文摘录：Dye-sensitized photocatalysis and electrokinetic streaming sensing are traditionally optimized as separate problems, yet both depend on the same solid-liquid interfacial charge distribution.
原文摘录：The RNA genome of the human Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its mRNAs contain a poly(A) tract at the 3' end of the positive strand that is essential for their replication, translation and stability.
原文摘录：Invasive non-typhoidal Salmonella (iNTS) infections, typhoid, and paratyphoid fever are major global health burdens, particularly considering increasing antimicrobial resistance.
体外研究显示，黄热病病毒（YFV）17D疫苗株与Asibi致病株感染后48小时出现翻译 shut-off 和应激颗粒（SG）形成，晚于24小时已出现的感染，可能与衣壳蛋白通过结合G3BP1抑制SG形成有关。
原文摘录：Kingella kingae is the leading cause of osteoarticular infections in children under 36 months of age. The pathogenesis of K. kingae disease begins with colonization of the oropharynx followed by translocation across the respiratory epithelium, entry into
一项在布基纳法索、马里、科特迪瓦、加蓬和刚果（金）十家机构开展的开放标签、多中心、随机、适应性、II期非劣效试验（NCT04546633，已完成），评估ganaplacide 400 mg联合lumefantrine固体分散体治疗非复杂性恶性疟儿童（6个月至<18岁）的食物效应与非劣效性，对照artemether-lumefantrine。
原文摘录：msDNA, or multi-copy single-stranded DNA, is a small satellite DNA observed in DNA extracts from a bacterial cell. A genetic element, usually found on the chromosome, called a retron, is responsible for producing msDNA.
原文摘录：AIMS: Bacterial infections of the cornea, also known as bacterial keratitis, are a major cause of blindness. The corneal surface is protected against infection by the flow of tear fluid, which displaces potential pathogens and debris. … These findings, obtained using two widely studied model strains, illustrate how microfluidic models of infection can offer valuable insights into how flow influences bacterial keratitis and guide the development of new treatments
原文摘录：Influenza is associated with increased thrombotic risk, and its viral RNA (vRNA) can be sensed by pattern-recognition receptor RIG-I, but the function of RIG-I in platelets remains unknown. … Our study is the first to demonstrate that platelets have a functionally active vRNA-sensing RIG-I receptor that finely tunes thrombotic risk and facilitates appropriate leukocyte transmigration during infection, through non-classical platelet activation
关注理由：这篇感染病学资料可用于了解领域进展，研究设计、结果和局限性值得一起阅读。
原文摘录：Porphyromonas gingivalis has long been recognized as a keystone pathogen associated with periodontal diseases and has more recently been implicated in systemic comorbidities beyond the oral cavity. However, amongst the oral microbiota, P. … gingivalis and its impact on host homeostasis and immune function
原文摘录：OBJECTIVES: To evaluate long-term mortality among sepsis survivors in Catalonia over a 15-year period and to identify factors associated with increased mortality within 2 years after hospital discharge. DESIGN: Retrospective population-based cohort study.
关注理由：这篇感染病学队列研究资料适合了解长期变化，研究对象、随访方式和结局指标建议一起查看。
《The Lancet Infectious Diseases》报道英国一例复发多发性骨髓瘤患者在接受双特异性抗体teclistamab治疗后发生淋巴细胞脉络丛脑膜炎病毒（LCMV）脑膜脑炎，经脑脊液宏基因组二代测序确诊，并有家养啮齿类动物接触史。
研究团队分析AMP两项平行试验至104周最终访视的HIV-1获得情况：静脉输注广谱中和抗体VRC01后，对VRC01高度敏感（IC80<阈限）的病毒感染被阻断，而随着体内VRC01浓度下降，在药物选择压力下 evolved 出更强耐药性的病毒以可检出的突破感染出现（VRC01组11例对安慰剂组1例）。结果提示单株抗体只能阻断敏感株，预防病毒逃逸与突破感染可能需要多种抗体联合。
原文摘录：WHO / Monika Mey Local health workers in Cambodia are trained in surveillance techniques, including stool examination using Kato-Katz, to detect schistosomiasis eggs, identify potential hotspots and support early detection and treatment. … int Related Global report on neglected tropical diseases 2026 Ending the neglect to attain the Sustainable Development Goals: A road map for neglected tropical diseases 2021–2030 WHO's work on neglected tropical diseases More WHO Global Neglected Tropical Diseases Programme
关注理由：关于感染病学的这条内容有明确出处，主要发现和适用人群可在原文中继续核查。
原文摘录：Viruses manipulate host cell membranes to evade antiviral immunity, prevent superinfection, and optimize their replication and spread. … Our study provides insights into the roles of NF-κB signaling in Ebola virus replication and immunopathogenesis, and identifies tetraspanin CD81 as a potentially druggable Ebola virus-inhibitory host factor
原文摘录：Aerosol transmission remains a critical route for the spread of respiratory infectious diseases, yet real-time exposure mapping in complex public spaces is computationally demanding.
作者在Clinical Microbiology Reviews发表叙述性综述，讨论有分枝杆菌病史或现症患者中慢性肺曲霉病（CPA，多由烟曲霉引起）与肺结核复发、非结核分枝杆菌（NTM）感染等鉴别困难及误诊后果。
一项发表于 Journal of Antimicrobial Chemotherapy 的系统综述（检索截至2026年2月）纳入9项研究、1600余名皮肤和软组织感染（SSTI）患者，评估丙磺舒联合β-内酰胺类抗生素治疗的有效性与安全性。
原文摘录：Transformative advances in the efficacy, simplicity, dosing, and safety profiles of antiretroviral therapy (ART) have revolutionized care for people with HIV.
原文摘录：The global escalation of antimicrobial resistance (AMR) poses a severe challenge to modern public health, necessitating novel classes of therapeutic agents.
一项多中心研究评估了在常规医疗中开始每半年一次来那卡韦（lenacapavir, LEN）HIV暴露前预防（PrEP）者的早期患者报告结局。减少给药频率带来的便利是启用LEN的主要动机，尽管注射部位反应常见但多为轻度，总体满意度较高；持续性结节和疼痛是患者对未来继续用药的主要顾虑。研究提示需以患者为中心的咨询和实施策略来优化长效PrEP的长期坚持。
研究者对来源于Geobacillus噬菌体的内溶素LysGPK进行了重组表达和表征，其对革兰阴性病原体具广谱裂解活性，最适裂解条件为37°C、pH 9.0，并在70°C下保持稳定。
原文摘录：The bacterial surface represents the primary interface between pathogens and hosts, yet its chemical and architectural complexity challenges conventional classification.
原文摘录：LYSC98 is a novel synthetic derivative from chemical modification of vancomycin. In this study, the antibacterial efficacy of LYSC98 was systematically evaluated against multiple clinically significant pathogens using Minimal Inhibitory Concentration (MIC … These results indicate that, within the strains, doses and models tested, LYSC98 is active against the Gram-positive species examined and is more effective than vancomycin in selected infection models
原文摘录：Endoplasmic reticulum (ER) oxidoreductases are promising targets for host-targeted antiviral agents (HTAs) because of their essential role in protein folding, including the maturation of viral proteins. … This new class of HTAs provides promising leads for drug discovery targeting viral envelope protein maturation vulnerabilities and is suitable for developing new BSAs
一项体外/活菌固体核磁共振研究以氘代棕榈酸标记杀鲑气单胞菌亚种完整菌膜，比较A-layer阳性噬菌体敏感株AS-R3、A-layer阴性敏感株AS-R5与不敏感株BIM93在噬菌体SW69-9暴露后的膜序变化。敏感株膜序明显下降，AS-R5活力显著丧失，BIM93维持膜结构与活力，AS-R3呈膜扰动但裂解有限的中间表型，提示噬菌体诱导的膜扰动取决于噬菌体敏感性与细菌包膜结构。
原文摘录：Disease Outbreak News Middle East respiratory syndrome coronavirus - Kingdom of Saudi Arabia 15 October 2026 See all DONs related to this event Situation at a glance Between 1 January and 5 October 2026, the Kingdom of Saudi Arabia reported eight laborato … int/emergencies/disease-outbreak-news/item/2026-DON618 See all DONs related to this event
原文摘录：Disease Outbreak News Pneumonia of undetermined etiology - Russian Federation 10 October 2026 See all DONs related to this event Situation at a glance On 2 October 2026, WHO became aware through media reports of the death of an employee of the Irkutsk Ant … item/2026-DON620 See all DONs related to this event
关注理由：这条感染病学资料适合作为深入阅读入口，尤其要关注研究方法与结论是否匹配。
原文摘录：Mycobacterium tuberculosis relies on the fatty acid synthase II (FAS II) pathway for the biosynthesis of mycolic acids, which are essential components of its lipid-rich cell envelope and major contributors to intrinsic drug resistance.
一项涵盖中国31个省份2013–2020年监测数据的研究，基于SEIRA模型以离散反演方法重构猩红热时变传播率β(t)，并用分布滞后非线性模型（DLNM）分析四种污染物与四种气象变量的关联。
原文摘录：Vibrational spectroscopic methods, mid- and near-infrared, and Raman spectroscopies, have been extensively applied to the study of microorganisms.