PubMed · Neuron· Victor Bodart-Santos·· 4 天前
神经内科：P2RX7 drives inflammatory microglia and pathogenic extracellular vesicle secretion in tauopathy.
P2RX7 drives inflammatory microglia and pathogenic extracellular vesicle secretion in tauopathy.
AI 导读
原文摘录：P2X purinoreceptor 7 (P2RX7), an ATP-gated ion channel, contributes to Alzheimer's disease (AD) progression, but its molecular mechanisms remain unclear. … Thus, P2RX7 regulates the FRM branch point, driving inflammatory microglial transition and EV-mediated spread of tau and toxic mitochondrial molecules and highlighting the P2RX7-EV axis as a therapeutic target in AD
来源：PubMed · Neuron · pubmed.ncbi.nlm.nih.gov