PubMed · Environment International· Bingxin Huangfu·· 11 天前
玉米赤霉烯酮作为分子胶促进PPARγ的K33链接泛素化降解，花色苷C3G可缓解其对小鼠葡萄糖代谢的影响（机制研究）
Zearalenone acts as a molecular glue to promote K33-linked ubiquitination and degradation of PPARγ and Its effects on glucose metabolism are mitigated by C3G.
AI 导读
环境国际（Environment International）发表的机制研究显示，真菌毒素玉米赤霉烯酮（ZEA）作为分子胶促进PPARγ发生K33链接多聚泛素化并经蛋白酶体降解，抑制其转录活性与下游糖酵解基因表达。
来源：PubMed · Environment International · pubmed.ncbi.nlm.nih.gov