疾病与人群
心血管疾病、卒中、高血压、血栓及相关药械、诊断和指南更新。
6 条精选近 30 天 2 条共收录 77 条
STAT新闻报道，诺华资助的III期HORIZON试验详细结果在美国心脏协会（AHA）科学年会上公布，并同步发表于《新英格兰医学杂志》。试验中pelacarsen大幅降低脂蛋白(a)——约五分之一人群携带的遗传性心血管风险因素——但近五年随访中，随机分配至药物或安慰剂的参与者在心梗、卒中、紧急冠脉血运重建和死亡方面均无差异。
关注理由：详细结果坐实此前top-line阴性信号：大幅降低Lp(a)未转化为心血管事件减少，动摇该研发通路的核心假设，可与NEJM同步发表原文对照核实具体数据。
原文摘录：BACKGROUND: Transcatheter mitral valve replacement (TMVR) is an approved treatment option for select high-risk patients with symptomatic mitral regurgitation (MR). … 001) and a mean Kansas City Cardiomyopathy Questionnaire overall summary score inc
关注理由：关注心血管医学时，这项队列研究提供了人群层面的观察线索，随访质量和潜在偏倚值得继续核查。
原文摘录：Intravascular lithotripsy (IVL) modifies vascular calcification to enhance vessel compliance and optimize coronary stent deployment. A novel 2-Hz coronary IVL catheter was developed to improve procedural efficiency by shortening treatment time. … The 2-Hz coronary IVL catheter, when used in patients with calcified coronary artery lesions, demonstrated sustained low rates of MACE alongside high rates of improvement in anginal symptoms through 1 year
关注理由：这篇心血管医学资料有原始研究可供追溯，临床意义还需结合研究人群和结局指标判断。
原文摘录：Intravascular ultrasound (IVUS) is a diagnostic modality providing information about lesion characteristics and optimizing results of percutaneous coronary intervention (PCI). … The results should be considered hypothesis generating and larger randomized studies with longer follow-up periods may be needed to further characterize the long-term sequelae of IVUS-guided versus angiography-guid
关注理由：这条心血管医学内容涉及随机对照研究，建议同时核对纳入人群、主要终点与报告结果。
原文摘录：Side branch (SB) wire jailing before main vessel (MV) stenting is widely used during provisional bifurcation percutaneous coronary intervention, but its benefit remains unclear. … In conclusion, wire jailing of the SB was associated with higher technical and procedural success and lower rates of final SB occlusion, with similar in-hospital and long-term MACE
关注理由：这条心血管医学资料涉及具体临床问题，研究人群、方法和结局指标可以结合原文进一步查看。
原文摘录：BACKGROUND AND PURPOSE: Myocardial fibrosis, a critical pathogenic driver of cardiovascular events, is primarily characterized by extracellular matrix deposition and cardiac fibroblast proliferation and activation.
关注理由：这条心血管医学资料涉及具体临床问题，研究人群、方法和结局指标可以结合原文进一步查看。