内分泌与代谢：Slowly Digestible Carbohydrates for GLP-1 Secretion
原文摘录：The goal of this clinical trail is to learn if the hormone, glucagon-like peptide-1 (GLP-1), is stimulated by slowly digestible carbohydrates (SDCs) in healthy adults.
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ClinicalTrials.gov API v2 · 登记更新 PubMed · British Journal Of Nutrition 膳食模式与男性睾酮-雌激素轴：基于骨质疏松性骨折男性研究（MrOS）1622名老年男性横断面分析及系统综述发表于British Journal of Nutrition
基于 Osteoporotic Fractures in Men Study 中1622名≥65岁男性的横断面分析显示，rEDIP每升高1个标准差与总睾酮（β=2·15。
PubMed · Clinical Pharmacology & Therapeutics 食物与饮料对口服PCSK9抑制剂enlicitide药代动力学及LDL-C降幅影响的I期研究
一项发表于Clinical Pharmacology & Therapeutics的研究通过三项I期开放标签交叉试验，在健康参与者中评估单次20 mg enlicitide decanoate在食物、2-8小时给药前禁食、水体积及黑咖啡、清茶等条件下的暴露变化。
PubMed · American Journal of Physiology-Endocrinology and Metabolism 线粒体氧甾醇信号在表观遗传调控与治疗研发中的综述：larsucosterol 2b期主要终点未达
作者综述线粒体胆固醇代谢与氧甾醇硫酸化如何经DNMT1、DNMT3A/3B活性影响DNA甲基化及肝细胞-巨噬细胞通讯，提出氧甾醇表观遗传“微调器”模型。
PubMed · Diabetes Care精选 内分泌与代谢：Common Genetic Variants Near SLC2A2 and Glycemic Response to Glimepiride in the GRADE Comparative Effectiveness Clinical Trial.
原文摘录：OBJECTIVE: Optimizing second-line therapy for type 2 diabetes remains challenging because of interindividual variability in response. Current treatment selection does not consider personal genetic profiles.
关注理由：这条内分泌与代谢内容涉及随机对照研究，除了结论，还应看看样本量、主要终点和不良事件报告。
WHO · Official News OData精选 内分泌与代谢：One in four adolescents worldwide reported no active days in the previous week
原文摘录：One in four adolescents worldwide reported not getting at least 60 minutes of physical activity on any day in the previous week. … Stand with science”, the theme of World Health Day 2026, marks a year-long campaign to highlight science as the foundation for protecting health and well-being worldwide
关注理由：这条内分泌与代谢资料适合作为深入阅读入口，尤其要关注研究方法与结论是否匹配。
PubMed · European Journal of Endocrinology 侵袭性垂体神经内分泌肿瘤的遗传学特征与恶性行为：39 例回顾性基因组队列研究
研究者在 39 例侵袭性垂体神经内分泌肿瘤（PitNET，62 个肿瘤样本）中用 MSK-IMPACT 平台行下一代测序，回顾性分析基因改变与转移状态及放疗后首次进展的 PFS、OS 的关联。
PubMed · Archives of Physical Medicine and Rehabilitation 肥胖人群功能性吸气肌训练随机对照试验：功能容量与有氧抗阻运动相当
一项单盲前瞻性随机对照试验纳入51名肥胖个体（平均年龄44.93±9.73岁，平均BMI 34.45±3.02 kg/m²），比较功能性吸气肌训练（FIMT）、有氧抗阻运动（ARE）与对照10周的效果。
PubMed · Endocrinology 内分泌与代谢：Imeglimin at clinical doses promotes glucose-stimulated insulin secretion and mitochondrial supercomplex formation.
原文摘录：Imeglimin is a novel antidiabetic agent that improves glycemic control by enhancing glucose-stimulated insulin secretion (GSIS).
PubMed · Mayo Clinic Proceedings 系统动力学模型预测英国2型糖尿病负担至2060年：血糖控制与GLP-1 RA的经济学影响
Mayo Clinic Proceedings发表一项基于英国医疗系统的系统动力学模型研究，预测2型糖尿病患病率将由2024年3.7M（5.3%）升至2060年6.3M（区间5.5-7.3M；8.3%），年总费用由207亿英镑增至334亿英镑。
PubMed · The Journal of Clinical Endocrinology & Metabolism 内分泌与代谢：Inflammatory signature of subcutaneous fat after weight loss and regain in women undergoing repeated bariatric surgery.
原文摘录：CONTEXT: Repeated metabolic-bariatric surgery (MBS, r-BS) represents 10-25% of all MBS and is commonly-performed for weight regain after prior significant weight-loss.
PubMed · Annals of Surgery 内分泌与代谢：Bariatric Surgery as a Rescue Strategy After Semaglutide or Tirzepatide.
原文摘录：OBJECTIVE: To evaluate 2-year weight loss after bariatric surgery among adults with intolerable adverse effects or inadequate weight loss with semaglutide or tirzepatide. … CONCLUSIONS: Bariatric surgery was associated with clinically meaningful 2-year weight loss after semaglutide or tirzepatide intolerance or inadequate response, with RYGB potentially offering greater benefit after inadequate response
PubMed · European Journal of Endocrinology 原发性醛固酮增多症患者病假与残疾养老金的纵向队列研究发表：与高血压对照相当，高于无高血压人群
一项基于瑞典登记数据的8年纵向队列研究纳入838名2019年18-67岁原发性醛固酮增多症（PA）患者及匹配的高血压与非高血压对照队列，评估病假与残疾养老金。PA患者年病假比例（21%）高于高血压组（17%）和无高血压组（10%），年均病假天数分别为27、20和9天；病假加残疾养老金合计天数与高血压组相近（54 vs 53），高于无高血压组（25）。
PubMed · Journal of Endocrinology 内分泌与代谢：Role of Growth hormone in the Pathogenesis of Podocytopathy and Diabetic Kidney Disease.
原文摘录：Kidney development and function rely heavily on growth hormone (GH) and its downstream effector, insulin-like growth factor-I (IGF-I). In type 1 diabetes mellitus (T1DM), elevated GH levels correlate strongly with glomerular injury and proteinuria.
PubMed · BMC Health Services Research精选 内分泌与代谢：Barriers to and facilitators of gestational diabetes mellitus service utilization in Kenya: a qualitative analysis of women's and healthcare workers' perspectives.
原文摘录：BACKGROUND: Gestational diabetes mellitus (GDM) is a growing global public health concern, particularly in low- and middle-income countries such as Kenya.
关注理由：这篇内分泌与代谢内容涉及具体研究方向，原文中的样本、结局和限制有助于理解其价值。
PubMed · British journal of surgery 代谢减重手术对比肥胖管理药物：379858例肥胖合并2型糖尿病成人的全国性重叠加权队列研究
一项全国性重叠加权队列研究纳入379858名肥胖合并2型糖尿病成人（32 401例接受代谢减重手术，347 457例起始肥胖管理药物），中位随访4.9年与4.3年。
FDA · MedWatch Safety Alerts精选 内分泌与代谢：Hospital Glucose Meter Correction: Nova Biomedical Updates Use Instructions for StatStrip Glucose Hospital Meter Systems
原文摘录：This recall involves implementing additional recommendations on the use of the StatStrip Glucose Hospital Meter System while awaiting a software update. … 10/20/2026 The FDA issued a communication notifying the public of a Class I Recall
关注理由：这篇内分泌与代谢内容涉及具体研究方向，原文中的样本、结局和限制有助于理解其价值。
PubMed · Metabolism 基于GBD数据的2026年全球肥胖及心-肾-肝代谢并发症流行病学更新研究发表
研究者分析全球疾病负担（GBD）研究数据，评估2023年20岁及以上成人超重和肥胖患病率及2000-2023年相关疾病趋势。2023年全球肥胖患病率约19.5%，较2000年上升约95%；MASLD、T2DM、CKD、痴呆及肥胖相关癌症年龄标化患病率同期上升，而年龄标化CVD患病率略降，提示心血管风险的多因素性质。作者呼吁采取人群层面综合防控策略。
PubMed · Journal of Endocrinology 内分泌与代谢：Vertical Sleeve Gastrectomy inhibits 11βHSD1 and subsequently reduces IL6 secretion in Mice and Humans: A Shared Anti-Inflammatory Mechanism.
原文摘录：BACKGROUND: Vertical sleeve gastrectomy (VSG) improves glycaemic control in type 2 diabetes (T2D) through mechanisms that extend beyond weight loss. The interaction between glucocorticoid metabolism and inflammation in this context remains unclear.
PubMed · Journal of Bone and Mineral Research 骨肌减少症综述：从机制到管理的叙述性回顾
《Journal of Bone and Mineral Research》发表一篇关于骨肌减少症（osteosarcopenia）的叙述性综述，梳理其与衰老特征、线粒体、营养合成代谢及骨因子/肌肉因子相关的机制研究进展。
PubMed · Environment International 玉米赤霉烯酮作为分子胶促进PPARγ的K33链接泛素化降解，花色苷C3G可缓解其对小鼠葡萄糖代谢的影响（机制研究）
环境国际（Environment International）发表的机制研究显示，真菌毒素玉米赤霉烯酮（ZEA）作为分子胶促进PPARγ发生K33链接多聚泛素化并经蛋白酶体降解，抑制其转录活性与下游糖酵解基因表达。
medRxiv · 独立预印本 内分泌与代谢：Gene-gene and Gene-Environment Interactions Improve Genetic Risk Predictions for Complex Diseases
原文摘录：Polygenic risk scores (PRS) assume additive SNP effects, yet genetic risk also arises from interactions between loci and environmental factors that contribute to broad-sense heritability. … A composite score was predictive over traditional additive PRS and predictive of T2D among individuals whose clinical symptoms fall within normal ranges
EMA · News and Safety Reviews精选 内分泌与代谢：Meeting highlights from the Committee for Medicinal Products for Human Use (CHMP) 12-15 October 2026
原文摘录：Image credit: © Marcos Osorio/Stocksy | stock.adobe.com Meeting highlights from the Committee for Medicinal Products for Human Use (CHMP) 12-15 October 2026 16 October 2026 Six new medicines recommended for approval; another five medicines recommended for … eu All other enquiries please submit your request via the online form Follow us on Bluesky Related medicine information Foundayo Rasonque Yuviwel Fovlussea Neuzafy Kizfizo Kyinsu Talvey Tukysa Tryngolza Yartemlea Mylotarg Truqap Ibrance
关注理由：这条内分泌与代谢资料涉及具体临床问题，研究人群、方法和结局指标可以结合原文进一步查看。
New England Journal of Medicine · Current Issue 内分泌与代谢：Retatrutide, a Triple Hormone Receptor Agonist, for Treatment of Obesity
原文摘录：New England Journal of Medicine, Volume 395, Issue 18, Page 1781-1793, November 5, 2026.
PubMed · Pharmacology Biochemistry and Behavior 内分泌与代谢：Antidepressant potential of agmatine: Effects on hypothalamic neurogenesis in rats with depressive behavior.
原文摘录：This study aimed to investigate the behavioral, neuroendocrine, and hypothalamic molecular effects of agmatine in rats exposed to chronic mild stress (CMS). … These findings suggest that agmatine exerts selective antidepressant-like and neuroendocrine effects under chronic stress conditions and may modulate hypothalamic IGF1R- and NPY related pathways