原文摘录：For older people (aged ≥80 years) with frailty or multimorbidity living with kidney failure, choosing a care pathway could involve deciding whether to prepare for dialysis long before it is needed.
原文摘录：CONTEXT: There is limited data of the associations between sex hormones and muscle mass and physical function in men over 80 years old.
Daniel T Engelman 等在 The Annals of Thoracic Surgery 发表特邀叙述性综述，分析2004至2026年33项心脏术后急性肾损伤药物预防的随机试验。
Biochemical Pharmacology 发表的综述系统梳理 c-Myc 在肾细胞癌（RCC）中的作用，指出其异常激活驱动肿瘤增殖、转移、免疫逃逃逸与治疗耐药，属于被视为“不可成药”的转录调控因子。
原文摘录：Among older people living with kidney failure and frailty or multimorbidity, we found no evidence that either preparing for responsive management or preparing for renal dialysis was superior in terms of QALYs over a mean follow-up duration of 4·5 years.
关注理由：关注肾脏病学时，这项随机对照研究可提供直接比较的证据，主要终点和研究局限需要一起阅读。
原文摘录：BACKGROUND: Severe hyperkalemia is a potentially life-threatening emergency, yet data focusing specifically on non-dialysis-dependent patients presenting to the emergency department (ED) with potassium levels ≥7.0 mmol/L remain limited. … These findings support a context-based approach to risk stratification and dialysis decision-making
关注理由：这篇肾脏病学资料涉及队列研究，建议重点关注入组人群、随访时长和结局定义。
研究者报告使用da Vinci SP系统经单个5 cm切口行单孔机器人腹膜外供肾切除术（SP-REDN）的技术与初步病例系列，2025年9月至2026年3月共13例活体供者，其中5例（38.5%）有腹部手术史。
Nephrology Dialysis Transplantation发表的综述通过5个典型病例描述透析中低血压（IDH）表型：急性过敏性事件、自主神经失衡相关急性IDH、目标体重过低致低血容量、超滤-再充盈失匹配及心脏储备受限的慢性IDH。
原文摘录：CDRH is issuing this Early Alert to notify the public of a potentially high-risk device issue. The FDA will keep the public informed and update this web page as significant new information becomes available. Affected Product The FDA is aware that B. … Health care professionals and consumers may report adverse reactions or quality problems they experienced using these devices to MedWatch: The FDA Safety Information and Adverse Event Reporting Program
关注理由：这条肾脏病学资料适合作为深入阅读入口，尤其要关注研究方法与结论是否匹配。
一例高度致敏患者接受伊米苷酶诱导肾移植后于第20天出现急性肾损伤，dd-cfDNA升至1.93%，活检示孤立性肾小球炎并C4d沉积，非HLA抗内皮细胞抗体阳性，符合Banff 2022抗体介导排斥（AMR）。
原文摘录：The human ciliopathy Alström syndrome is caused by mutations in ALMS1. How ALMS1 contributes to cilia function has been unclear.
小鼠条件性基因敲除研究显示，在尿生殖窦（胚胎膀胱-尿道原基）中条件性失活转录因子Yy1可致输尿管梗阻、肾积水与输尿管积水，输尿管无法与膀胱连接，并伴尿生殖窦嵴缺失、尿路上皮分化障碍。RNA-seq与YY1染色质结合数据整合提示多个差异表达基因为YY1直接靶点，涉及线粒体功能与稳态。研究结果支持YY1是膀胱形态发生的关键转录调控因子，属临床前动物发现。
原文摘录：Signaling events leading to fungal growth and septation depend on key cytoskeletal proteins, including actin, microtubules, and septin GTPases, that assemble into oligomeric structures and filaments and associate with cellular membranes.
美国生理学会旗下American Journal of Physiology-Renal Physiology发表的C57BL/6J小鼠研究显示，NaHCO₃负荷10天使雄鼠肾脏KCC3a蛋白丰度上调，雌鼠则无变化，基线表达和mRNA水平相近。去睾可消除雄鼠上调，补5α-双氢睾酮仅部分恢复，卵巢切除不影响雌鼠反应，提示睾丸来源因子（非睾酮单独）参与雄性特异的代谢性碱中毒肾脏适应调控。
原文摘录：Sex-specific differences in pharmacokinetics are increasingly recognized as clinically relevant, yet most population pharmacokinetic models for antibiotics have been developed in predominantly male populations with limited transferability to female patien … A female-specific population pharmacokinetic model of piperacillin was developed and externally validated, demonstrating robust predictive performance and clear benefits for Bayesian forecasting
一项纳入25例3-5期慢性肾脏病（CKD）患者的随机对照试验（19例运动组、6例常规照护），评估12周家庭化个体化运动（高强度间歇训练、健步走与力量训练）对骨骼肌的影响，运动前后行股外侧肌活检。
本综述总结基于电化学免疫传感器检测急性肾损伤（AKI）生物标志物KIM-1和NGAL（可测于血清和尿液）的近期进展，并比较各传感器的检测限等分析性能。作者指出目前仍需进一步研究，开发能在临床诊断AKI中被广泛接受的最优传感器，尤其是面向早期和即时检测的应用。
一项对653名COVID-19住院幸存者（46%女性，28%≥65岁）出院后8±2个月的前瞻性队列横断面分析显示，53%存在体力缺乏活动（<150分钟/周）。