Cell Reports发表临床前研究：进食-禁食节律而非肿瘤内在时钟决定结直肠癌对PPAR拮抗剂的敏感性
Cell Reports于2026-11-06在线发表的这项研究（PMID 42993626）在结直肠癌细胞2D/3D模型、患者来源类器官及荷瘤小鼠中发现，进食-禁食节律而非肿瘤内在时钟决定对PPAR拮抗剂的敏感性。
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PubMed · Cell Reports PubMed · Clinical Cancer Research 探索性分析：剂量中断与减量对四种EGFR突变非小细胞肺癌TKI疗效的影响
研究者收集支持afatinib、dacomitinib、mobocertinib和osimertinib获FDA原批准的临床试验患者水平数据，用时间依赖Cox模型和30/60/90天landmark模型分析日剂量及早期剂量修改对EGFR突变非小细胞肺癌PFS和OS的影响，研究发表于Clinical Cancer Research（PMID 42993168）。
EMA · News and Safety Reviews 肿瘤学：Meeting highlights from the Committee for Veterinary Medicinal Products (CVMP) 3-5 November 2026
原文摘录：Meeting highlights from the Committee for Veterinary Medicinal Products (CVMP) 3-5 November 2026 6 November 2026 Outcomes of the Committee for Veterinary Medicinal Products (CVMP) meeting News Veterinary Medicines CVMP opinions on veterinary medicinal pro … Related content Committee for Medicinal Products for Veterinary Use (CVMP): 3-5 November 2026 Committee for Veterinary Medicinal Products (CVMP) Related medicine information Credelio Quattro Credelio Nobivac PLUS DHPPi / Leptos Laverdia Scovella
PubMed · Clinical Cancer Research 肿瘤学：Multiomics Analysis of Malignant Pleural Mesothelioma Reveals the Immunological Microenvironment Associated with MTAP Loss and Immunotherapy Outcomes.
原文摘录：PURPOSE: Nivolumab plus ipilimumab is a standard first-line therapy for unresectable malignant pleural mesothelioma (MPM), yet biomarkers predicting immune checkpoint inhibitor (ICI) efficacy remain undefined. … MTAP loss was linked to immune-related features and a higher ICI response, supporting further investigation of MTAP loss as a candidate biomarker
ClinicalTrials.gov API v2 · 登记更新精选 肿瘤学：Selumetinib in Treating Young Patients With Recurrent or Refractory Low Grade Glioma
原文摘录：This phase I/II trial studies the side effects and the best dose of selumetinib and how well it works in treating or re-treating young patients with low grade glioma that has come back (recurrent) or does not respond to treatment (refractory).
关注理由：这条肿瘤学内容涉及相关临床或研究问题，建议查看原文中的方法与适用范围。
PubMed · JNCI Journal of the National Cancer Institute 肿瘤学：The ethical dilemma of excluding patients from clinical trials based on language preference.
原文摘录：Patients who prefer a language other than English (LOE) are underrepresented in clinical research trials. The reasons for lower enrollment are multi-faceted, and the literature lacks a good understanding of these causes or how to address them.
PubMed · Bioinformatics 肿瘤学：DeSCENT: Deconvolutional Single-Cell RNA-seq Enhances Transcriptome-based Cancer Survival Analysis.
原文摘录：MOTIVATION: Single-cell RNA-seq captures tumor heterogeneity, but it is rarely available together with patient survival outcomes. Bulk RNA-seq cohorts provide survival data but lack direct measurements of cellular expression.
PubMed · Clinical Cancer Research 肿瘤学：Integrated multi-omics reveals longitudinal metabolic dynamics and reprogramming in bladder cancer.
原文摘录：PURPOSE: Bladder cancer (BCa), particularly NMIBC, poses a substantial clinical burden due to its high recurrence rates and the need for lifelong surveillance.
PubMed · Endocrine Reviews 肿瘤学：Glucagon-like Peptide-1 Receptor Agonists and Thyroid Cancer: Review of Preclinical and Human Data.
原文摘录：Preclinical rodent studies showing a dose-dependent increase in thyroid C-cell hyperplasia and neoplasia with Glucagon-like Peptide-1 Receptor Agonists (GLP-1RAs), led the United States Federal Drug Administration to require a boxed warning contraindicati … Because the preponderance of data does not support a causative relationship between GLP-1RA use and MTC (or PTC), we conclude that the need for the boxed warning about the risk of C-cell neoplasia is no longer necessary
PubMed · Cancer Cell Cancer Cell评论：新辅助治疗早期终点研究显示CPS + EG与Neo-Bioscore可预测患者层面而非试验层面长期结局
Cancer Cell本期Conforti等报告，CPS + EG和Neo-Bioscore评分在新辅助治疗中可在患者层面预测长期结局，但在试验层面不能可靠预测，提示需要能跨试验可靠反映疗效的更好早期终点。该评论指出早期终点作为长期结局替代指标对疗效评估的重要性。
PubMed · Cancer Research 肿瘤学：Regulatory T Cell Interventions to Boost Anti-tumor Immune Responses.
原文摘录：FOXP3-expressing regulatory T cells (Tregs) are a specialized subset of T lymphocytes that are crucial for maintaining immune homeostasis and preventing autoimmunity.
ClinicalTrials.gov API v2 · 登记更新 肿瘤学：A Single-Arm Study of Nimotuzumab Combined With NALIRIFOX as First-Line Treatment for Pancreatic Cancer
原文摘录：This is a prospective, single-arm study in patients with locally advanced or metastatic pancreatic cancer that cannot be treated with surgery. The study is planned to enroll 42 patients.
PubMed · Gynecologic Oncology 高危局部晚期宫颈癌腹主动脉旁淋巴结影像学阴性者：预防性延伸野照射与盆腔放疗的回顾性队列比较研究
一项回顾性队列研究纳入293例FIGO 2018 III-IVA期、腹主动脉旁淋巴结影像学阴性且伴高危特征的局部晚期宫颈癌患者，比较预防性延伸野照射（EFI，n=140）与盆腔放疗（PRT，n=153）。
PubMed · Clinical Cancer Research 肿瘤学：Comparison of PSMA- and CD70-targeted PET/CT in The Diagnosis of Renal Cell Carcinoma: A Retrospective Cohort and Prospective Head-to-head Study.
原文摘录：PURPOSE: Currently, PSMA- and CD70-targeted imaging are the main focuses in the molecular imaging of RCC, but these modalities have not been compared in clinical studies.
ClinicalTrials.gov API v2 · 登记更新 肿瘤学：Hepatic Artery Infusion of Carfilzomib in Participants With Liver Metastatic Disease Previously Treated With Hepatic Artery Infusion Pump Therapy
原文摘录：Background: Cancers that begin in the colon, adrenal glands, or bile ducts may spread to the liver. These liver tumors are often treated using a hepatic artery infusion (HAI) pump.
PubMed · Carcinogenesis Carcinogenesis（致癌机制）综述：提出以测量为中心的框架刻画“癌症之前”的暴露组生物学状态
Carcinogenesis 期刊发表一篇综述，提出以测量为中心的框架，用组织生理、纵向生物标志物、遗传与表观遗传信息及内外暴露的定量评估，识别临床可检出癌症之前可能存在的生物学状态，区分短暂生理波动与以幅度、持续时间、可重复性和轨迹为特征的持续偏离。该框架强调这些过程并非癌症特异，不预设恶性进展为决定性，其转化仍需分析与临床验证、因果推断、纵向结局研究及过度诊断评估。
PubMed · JNCI Journal of the National Cancer Institute 肿瘤学：The risk of gastric mucosa-associated lymphoid tissue (MALT) lymphoma after Helicobacter pylori eradication treatment.
原文摘录：BACKGROUND: Helicobacter pylori eradication leads to complete tumor regression in most gastric mucosa-associated lymphoid tissue (MALT) lymphomas. … CONCLUSION: From six years after Helicobacter pylori eradication treatment, the risk of gastric MALT lymphoma was no longer higher than that of the background population
PubMed · Molecular Biology and Evolution 肿瘤学：PhytClust: Efficient and Optimal Monophyletic Partitioning of Rooted Phylogenetic Trees.
原文摘录：Phylogenetic trees play a fundamental role in elucidating evolutionary relationships among taxa. Clustering taxa remains a major challenge across diverse biological domains such as cancer genomics, microbial systematics, and phylogenomics.
PubMed · Gynecologic Oncology 表达hIFNβ与NIS的静脉注射水疱性口炎病毒VSV-hIFNβ-NIS治疗IV期或复发性子宫内膜癌的I期试验发表
Gynecologic Oncology发表一项I期、3+3剂量递增试验，21例IV期或复发性子宫内膜癌患者接受单次静脉输注VSV-hIFNβ-NIS（2017-09-15至2023-01-10），主要终点为最大耐受剂量（MTD），因药物生产限制未升至DL5，MTD未达到。
PubMed · JNCI Journal of the National Cancer Institute精选 肿瘤学：Treatment-related neutropenia as predictor of response to adjuvant palbociclib in the PALLAS trial (ABCSG-42/AFT-05/BIG-14-13/PrE0109).
原文摘录：BACKGROUND: Prior analyses of PALLAS (NCT02513394), a phase III trial that randomized patients with stage II-III hormone receptor-positive breast cancer to receive adjuvant palbociclib plus endocrine therapy (ET) or ET alone, did not show benefit of the c … gov, NCT02513394
关注理由：这条肿瘤学内容涉及随机对照研究，建议同时核对纳入人群、主要终点与报告结果。
PubMed · Cancer Research 肿瘤学：Integrated Whole-Genome and Transcriptome Sequencing Reveals Divergent Evolutionary Processes Across Biliary Tract Cancer Subtypes.
原文摘录：Biliary tract cancer (BTC) comprises a family of rare malignancies subclassified by anatomy and pathology. However, this classification scheme may obscure shared biology and limit patient stratification.
PubMed · British Journal of Cancer精选 肿瘤学：Which is more effective at improving uptake of bowel cancer screening: text message reminders or patient navigation? Results from a three-arm RCT.
原文摘录：BACKGROUND: Text message reminders (TMRs) and patient navigation (PN) increase bowel cancer screening uptake. To date, no studies have directly compared these interventions with one another. … TRIAL REGISTRATION: ISRCTN17245519
关注理由：关注肿瘤学时，这项随机对照研究可提供直接比较的证据，主要终点和研究局限需要一起阅读。
PubMed · Advanced Drug Delivery Reviews 综述：口服节拍化疗的生物药剂学屏障与先进制剂策略——从急性干预走向癌症长期管理
《Advanced Drug Delivery Reviews》发表的综述回顾节拍化疗（MET）在癌症治疗中的角色：通过长期低剂量、持续或间歇给药（含每日至每周的无药间歇），依托抗血管生成、免疫调节和改变肿瘤微环境发挥抗肿瘤作用，并减少治疗相关毒性。文章比较了不同给药途径，分析口服递送面临的溶解度差、渗透性低和口服生物利用度不足等生物药剂学屏障，并总结旨在克服这些限制的新兴制剂策略与先进递药系统。
PubMed · Nature Nanotechnology Nature Nanotechnology发表研究：树突状细胞借Arc基因生成内源性病毒样囊泡增强肿瘤疫苗免疫激活（临床前）
研究团队报告树突状细胞利用逆转座子衍生Arc基因生成内源性病毒样囊泡（VLVs），富集肽-MHC与共刺激配体，通过病毒模拟直接激活T细胞并迁移至淋巴器官。在小鼠模型中，Arc过表达使囊泡偏向VLVs，驱动CD4辅助的T细胞启动与CD8偏斜记忆，抑制黑色素瘤并延长生存期，而缺乏Arc的细胞外囊泡不能启动抗原特异性T细胞应答。
PubMed · Cancer Research 肿瘤学：Selection for Targeted Therapy Resistance Indirectly Selects for Cancer Cells with Enhanced Phenotypic Plasticity and Evolvability to Orthogonal Stressors.
原文摘录：Resistance to targeted therapies is frequently associated with stem-like features and partial epithelial-to-mesenchymal transition (EMT). … Constraining plasticity could delay resistance and extend response durability
PubMed · Advanced Science 表观遗传激活ANGPTL4通过中性粒细胞招募与NET释放并稳定ANXA5驱动EBV阴性胃癌（Advanced Science机制研究）
一项机制研究显示，EBV阳性胃癌中EBV感染诱导ANGPTL4启动子高甲基化致其转录沉默，而EBV阴性胃癌中低甲基化介导的ANGPTL4过表达与不良预后及远处转移相关。
PubMed · Biochemical Pharmacology 肿瘤学：MYC in renal cell carcinoma pathogenic mechanisms and pharmacological intervention strategies.
原文摘录：As a pleiotropic master transcriptional regulator that controls an extensive, context-dependent repertoire of target genes governing cell-fate determination, the oncoprotein c-Myc has long been regarded as an "undruggable" therapeutic target.
PubMed · Cell Death and Differentiation ENPP1 抑制 cGAS-STING 通路介导 EGFR-TKI 耐药非小细胞肺癌的免疫逃逸
研究者在奥希替尼耐药肿瘤模型中发现 ENPP1 显著上调，其通过水解胞外 cGAMP 抑制免疫细胞 cGAS-STING 通路、削弱免疫激活，促进免疫抑制与肿瘤进展；基因敲除或药物抑制 ENPP1 在体外和体内增强免疫细胞对耐药肿瘤的杀伤，配对临床样本亦显示耐药后 ENPP1 表达升高。
PubMed · Oncotarget DUSP4敲低抑制BRAF V600E突变结直肠癌模型增殖但经DUSP5适应性反馈限制疗效
研究者在体外和体内BRAF V600E突变及BRAF抑制剂耐药结直肠癌模型中显示，DUSP4敲低诱导G1期细胞周期阻滞并减少增殖，同时引发部分由DUSP5介导的适应性反馈反应。治疗达到肿瘤停滞但未见肿瘤缩小，提示DUSP4作为单药靶点的疗效可能有限。文章为开放获取，发表于Oncotarget（PMID: 42985965）。
PubMed · The Lancet Oncology Pumitamig 联合白蛋白结合型紫杉醇一线治疗晚期三阴性乳腺癌的单臂 Ib/II 期试验报告活性与安全性
一项在中国十家中心开展的单臂 Ib/II 期试验（ChiCTR2200060400，NCT05918133）评估 pumitamig（靶向 PD-L1 与 VEGF-A 的双特异性抗体）联合白蛋白结合型紫杉醇一线治疗不可切除局部晚期或转移性三阴性乳腺癌，42 名中国女性患者入组，主要终点为确认客观缓解率与安全性。
PubMed · Biophysical Journal 肿瘤学：Ultrasound cavitation triggered formation of intracellular stress granules.
原文摘录：Ultrasound cavitation has potential applications in drug delivery and cancer therapy, but the cellular responses to its mechanical and chemical effects remain incompletely understood. … These findings revealed that ultrasound cavitation could induce the formation of persistent, stress granules within cells
PubMed · Journal of Clinical Epidemiology 研究建立EORTC QLQ-CR29量表的临床重要性阈值以解读结直肠癌患者个体PRO评分
一项纳入来自六个国家的240例结直肠癌患者（平均年龄62.2岁，53%为男性）的研究，通过锚定问题和ROC分析为EORTC QLQ-CR29量表的22个量表建立了临床重要性阈值（TCIs）。
The Lancet · Online 肿瘤学：[Seminar] Retinoblastoma
原文摘录：Retinoblastoma, the most common primary intraocular malignancy of childhood, represents a substantial global health equity concern, exemplifying profound disparities in global burden and outcome despite being a largely curable cancer. … approximately half of these cases instead show high-level amplification of the MYCN oncogene
New England Journal of Medicine · Current Issue 肿瘤学：PARP and Androgen-Signaling Inhibition in Metastatic Prostate Cancer
原文摘录：New England Journal of Medicine, Volume 395, Issue 18, Page 1872-1875, November 5, 2026.
PubMed · Journal of Biological Chemistry 靶向CLDN3破坏NF-κB/p65-CXCL1-PD-L1轴增强抗PD-1疗效：胃癌临床前研究发表于Journal of Biological Chemistry
研究者报告CLDN3在胃癌组织中上调，与不良预后及肿瘤内CD8+ T细胞浸润减少相关，并通过促进p65磷酸化入核增强CXCL1转录、以CXCL1依赖方式上调PD-L1，介导免疫逃逸；研究基于临床队列、体外、体内及多组学分析（PMID 42982193）。
PubMed · Cell 肿瘤学：CRISPR mutagenesis of the MYC locus reveals a druggable ultraconserved RNA element.
原文摘录：Noncoding sequences comprise most of the human genome; however, their functional significance remains largely elusive. Using CRISPR tiling mutagenesis with near-PAMless, high-fidelity SpRY-Cas9, we mapped the fitness landscape of an entire human gene, the
PubMed · Breast Cancer Research and Treatment 医疗补助受益乳腺癌患者内分泌治疗共付金额极低且与用药依从性无关：2016–2018年10,307例队列分析
一项观察性研究纳入2016–2018年确诊乳腺癌并配药内分泌治疗的10,307例Medicaid（医疗补助）女性，随访至2019年12月31日，平均（SD）共付金额仅$1.85（$1.28），范围$0.17–$8。
PubMed · British Journal of Cancer精选 肿瘤学：Long-term fatigue based on the EORTC QLQ-C30 up to five years after radiotherapy and its trajectories in men diagnosed with non-metastatic prostate cancer in the international REQUITE study.
原文摘录：BACKGROUND: Fatigue is a common symptom in cancer patients associated with impaired quality of life (QoL). Little is known about long-term fatigue trajectories in prostate cancer (PCa) patients. … PCa patients with elevated pre-radiotherapy fatigue levels and diabetes may require closer monitoring in risk-stratified aftercare programmes
关注理由：这条肿瘤学内容涉及相关临床或研究问题，建议查看原文中的方法与适用范围。
PubMed · Experimental Cell Research 综述：TWIST转录因子在宫颈癌分子机制与临床意义中的作用
发表于Experimental Cell Research的综述系统梳理转录调节因子TWIST在宫颈癌中的作用：其表达受缺氧HIF-1α、TGF-β及Wnt/β-catenin、PI3K/Akt等多条通路调控，高危HPV E6/E7蛋白促进其上调，通过诱导EMT、下调E-cadherin及MDR1/P-糖蛋白等机制参与转移、化疗和放疗抵抗。
PubMed · Breast Cancer Research and Treatment 乳腺癌数字压力管理干预（StressProffen CBI/MBI）18个月随访未见总体显著获益
Coping After Breast Cancer（CABC）随机试验对430例乳腺癌患者随访至干预访问后18个月，76%（n=327）完成调查。线性混合效应模型显示，CBI、MBI与常规照护三组感知压力（主要结局）等指标均呈稳定趋势，干预组与对照组间无显著差异；但≤50岁参与者在两组干预中压力下降更大，全样本中基线压力水平较高者预示更大压力下降。此前6个月随访亦未显示干预优于常规照护。