小鼠研究显示精子PLCζ1与PLCδ4协同介导受精钙振荡与生育力
研究者利用CRISPR/Cas9构建Plcζ1与Plcδ4基因敲除及双敲除（DKO）小鼠，发现PLCζ1是受精钙振荡的主要触发因子，PLCδ4起代偿作用但无法独立驱动钙信号，DKO雄鼠不育且精子不能诱导钙振荡。结果表明哺乳动物受精钙信号启动存在分子特化，对理解雄性不育和改进辅助生殖技术有提示意义，属动物模型研究，DOI与期刊信息按PubMed记录保留。
#妇产科学
PubMed · PLoS Biology PubMed · Journal of Clinical Microbiology 妇产科学：Evaluation of a new assay for the detection of IgM in recent and congenital Toxoplasma infections.
原文摘录：UNLABELLED: Toxoplasma gondii infection is usually asymptomatic in immunocompetent individuals. However, primary infection during pregnancy can lead to severe fetal manifestations. … In addition, agreements with the Architect To
PubMed · Gynecologic Oncology 高危局部晚期宫颈癌腹主动脉旁淋巴结影像学阴性者：预防性延伸野照射与盆腔放疗的回顾性队列比较研究
一项回顾性队列研究纳入293例FIGO 2018 III-IVA期、腹主动脉旁淋巴结影像学阴性且伴高危特征的局部晚期宫颈癌患者，比较预防性延伸野照射（EFI，n=140）与盆腔放疗（PRT，n=153）。
PubMed · Development 妇产科学：The Bicaudal-C repression domain couples translational silencing to maternal embryonic patterning.
原文摘录：The maternal period of embryonic development occurs before zygotic transcription is active and therefore relies heavily on post-transcriptional mechanisms such as regulated mRNA translation. … These findings reveal how a modular RBP can coordinate stage-specific translational control during embryogenesis
PubMed · PEDIATRICS 妇产科学：Facial Dysmorphism in Infants Following Combined Prenatal Exposure to Alcohol and Tobacco.
原文摘录：OBJECTIVES: Alcohol and smoking have well-established teratogenic effects; however, despite their frequent co-use during pregnancy, the combined impact on fetal development remains less understood. … These findings highlight the importance of interventions targeting alcohol and smoking cessation during pregnancy to reduce teratogenic risk
PubMed · Gynecologic Oncology 表达hIFNβ与NIS的静脉注射水疱性口炎病毒VSV-hIFNβ-NIS治疗IV期或复发性子宫内膜癌的I期试验发表
Gynecologic Oncology发表一项I期、3+3剂量递增试验，21例IV期或复发性子宫内膜癌患者接受单次静脉输注VSV-hIFNβ-NIS（2017-09-15至2023-01-10），主要终点为最大耐受剂量（MTD），因药物生产限制未升至DL5，MTD未达到。
PubMed · American Journal of Obstetrics and Gynecology 巴氯芬阴道栓治疗慢性盆腔痛的随机双盲安慰剂对照试验发表摘要
一项发表于 American Journal of Obstetrics and Gynecology 的随机双盲安慰剂对照试验在 37 例慢性盆腔痛女性中比较每晚 20mg 巴氯芬阴道栓与安慰剂栓，主要终点为 8 周标准化盆底肌检查 100mm VAS 疼痛评分较基线的变化，试验按 20mm MCID 设计，总样本量计划 34 例。
PubMed · Journal of Clinical Investigation 母胎界面蜕膜效应样记忆CD8+ T细胞经CX3CL1-CX3CR1轴介导局部抗菌防御且不破坏胎儿耐受的研究
一项发表于 Journal of Clinical Investigation 的人与小鼠机制研究（PMID: 42986696）识别出人CD45RA+、鼠CX3CR1+的蜕膜富集效应样记忆CD8+ T细胞亚群，其募集依赖CX3CL1主导的趋化因子微环境。
PubMed · American Journal of Epidemiology 妇产科学：Neighborhood deprivation and the risk of stillbirth in New York.
原文摘录：Stillbirth (fetal death ≥ 20 weeks gestation) occurs in approximately 21,000 births each year in the United States. Previous studies have observed associations between neighborhood deprivation and adverse perinatal outcomes. … Our findings highlight that women residing in the most deprived NDI quartile could benefit from enhanced prenatal services and support
PubMed · Anesthesiology 多中心回顾性队列分析289,047例剖宫产产科麻醉最佳实践依从率
研究者利用MPOG数据库对2015至2022年289,047例15至44岁女性剖宫产开展多中心回顾性队列分析，评估七项产科麻醉最佳实践的依从率。
The Lancet · Online精选 妇产科学：[Comment] Inclusion of pregnant and lactating women in the Tumaini vaccine efficacy trial: a landmark advance
原文摘录：The Tumaini trial protocol (NCT07842107) developed by the National Institute of Biomedical Research of the Democratic Republic of the Congo and partners to evaluate the efficacy of vaccines against Bundibugyo virus (BDBV) includes pregnant and lactating w
关注理由：这篇妇产科学内容涉及具体研究方向，原文中的样本、结局和限制有助于理解其价值。
PubMed · Human Reproduction 卵巢储备功能减退女性粪便微生物组与代谢组改变：横断面观察研究显示Hoylesella与AMH/AFC相关、硬脂酸为关键差异代谢物
一项横断面观察研究纳入郑州大学第一附属医院190名冻胚移植女性（卵巢储备功能减退DOR 91例、正常卵巢储备NOR 99例），以16S rRNA测序和非靶向代谢组学分析肠道微生物与代谢谱。
PubMed · Reproduction 妇产科学：Selective depletion of AMH-expressing granulosa cells in vivo impairs follicular development and fertility in female mice.
原文摘录：In brief: We establish an in-vivo mouse model for conditional and selective depletion of anti-Müllerian hormone-expressing granulosa cells and reveal their contribution to follicular development and female fertility.
PubMed · Obstetrics and Gynecology HALT-C 产前关怀衔接捆绑策略提升产后丙肝直接抗病毒药物处方率
美国中西部一家大型医疗系统实施 HALT-C（丙肝产前关怀衔接）质量改进捆绑策略，比较实施前62例与实施后35例符合条件的妊娠，评估产后6个月内直接抗病毒药物处方情况。
PubMed · Journal of Personality and Social Psychology 妇产科学：When consensus can change hearts and minds: Sacred values and edge cases.
原文摘录：Consensus information can change people's minds, especially in ambiguous situations. But can it also change people's hearts by influencing their deeply held convictions? … (PsycInfo Database Record (c) 2026 APA, all rights reserved)
PubMed · Human Reproduction ESGE-ESHRE-IFFS 国际共识发布生殖障碍女性诊断性宫腔镜检查的结构化报告模板
ESGE、ESHRE 与 IFFS 联合工作组通过虚拟名义组技术达成国际共识，发布首个针对生殖障碍女性诊断性宫腔镜检查的结构化报告模板，将发现分为患者特征及阴道、宫颈、子宫腔、子宫内膜和输卵管开口五个部分的系统记录。该文件旨在解决既有报告缺乏统一框架导致的可重复性不足和研究异质性问题；共识原文仅见于摘要，结构化报告条目本身不构成该检查诊断价值的证据。
PubMed · Obstetrics and Gynecology ACOG发布绝经相关血管舒缩、睡眠和情绪症状管理临床实践指南
美国妇产科医师学会（ACOG）发布临床实践指南，为40岁及以上自发或诱导绝经相关的血管舒缩、睡眠和情绪症状提供循证管理推荐，目标人群为出生时被分配女性性别的围绝经及绝经后个体（含女性、跨性别男性和性别多元人群）。
PubMed · Fertility and Sterility 单中心回顾性队列：无排卵受孕周期改变孕早期子宫动脉搏动指数与子痫前期风险的关联
比利时布鲁塞尔大学医院对2021年5月至2023年12月3,651例单胎妊娠在孕11至14+1周行子宫动脉多普勒评估的单中心回顾性队列研究显示，搏动指数与子痫前期风险的关联因受孕方式而异：自然受孕妊娠中较高搏动指数与子痫前期相关（OR 5.31。
PubMed · International Journal of Epidemiology CARRS 队列前瞻性研究：南亚女性高血压与自然绝经提前相关
一项基于印度 CARRS 队列（2010–2024）的前瞻性研究分析 2225 名 30–50 岁月经期南亚女性的基线心血管代谢指标与自然绝经时间的关系，44% 在随访中达到自然绝经，中位绝经年龄 46 岁。
PubMed / NCBI E-utilities 妇产科学：Influence of perineal tears and body image disturbance on postpartum sexual quality of life: a cross-sectional study.
原文摘录：BACKGROUND: Whether perineal injury severity independently determines postpartum sexual quality of life (SQoL) is unclear. This study evaluated perineal tears and body image as determinants of SQoL and sexual resumption timing. … OASI carries a substantial risk of delayed sexual resumption, warranting dedicated postpartum counseling
PubMed / NCBI E-utilities 妇产科学："Sailing Two Boats" the fragmented identity of working women and the hidden labor of infertility: a qualitative analysis.
原文摘录：OBJECTIVE: To explore how professional women undergoing assisted reproductive technology (ART) experience and manage conflicts between treatment demands and professional identity; and to identify ways healthcare professionals can support them.
PubMed · Neuroscience Letters 妇产科学：Maternal separation reshapes layer-specific PV-PNN architecture in the mouse barrel cortex.
原文摘录：Early-life adversity alters inhibitory circuit maturation across developing brain systems, but most studies have focused on corticolimbic regions involved in emotional and cognitive regulation. … This layer-specific pattern suggests that early-life stress may alter the timing or distribution of plasticity and stabilization within primary sensory circuits, with potential consequences for how tactile information is filtered and integrated during cortical maturation