肿瘤转录组融合基因检测流程 RIFTT 发表，基准测试中候选数最多减少 95%
研究者发布肿瘤转录组融合基因检测流程 RIFTT，整合 Arriba 与 FusionCatcher 两个检测工具，并引入 Promiscuity Score、Fusion Transcript Score 与 Robustness Score 评分指标。
#肿瘤
PubMed · BMC Bioinformatics
PubMed · Cancer Cell 临床前研究：血小板PAR4信号以性别特异方式调控胶质母细胞瘤抗肿瘤免疫
一项发表于Cancer Cell的研究（PMID 42956742）发现，PAR4介导的血小板反应性增高参与胶质母细胞瘤（GBM）抗肿瘤免疫的性别差异。在小鼠模型中，药物或基因抑制PAR4仅在雌性中延长生存，且该作用依赖雌激素，通过肿瘤微环境中CD8+T细胞浸润与功能增强介导，并与雌激素受体β（ERβ）信号相关。结果来自动物模型，PAR4作为治疗靶点尚需临床验证。
PubMed · Cancer Cell 患者来源类器官研究提示胰腺癌KRAS G12D靶向药敏感性依赖干扰素信号
一项发表于Cancer Cell的临床前研究整合基因组、转录组和蛋白组分析242例胰腺癌患者来源类器官及配对肿瘤组织，发现一部分KRAS G12D突变类器官对KRAS G12D靶向治疗内在耐药，伴先天免疫信号通路下调。
EMA · Withdrawn Applications精选 肿瘤学：Withdrawn application: Ibrance, 15/10/2026
原文摘录：Ibrance - withdrawal of application for variation to marketing authorisation Application withdrawn The application for a change to this medicine's authorisation has been withdrawn palbociclib Post-authorisation Human Overview Pfizer Europe MA EEIG withdre … News on Ibrance Meeting highlights from the Committee for Medicinal Products for Human Use (CHMP) 12-15 October 2026 16/10/2026 Meeting highlights from the Committee for Medicinal Products for Human Use (CHMP) 12-15 September 2016 (corrected) 21/09/2016 New treatment for breast cancer 16/09/2016 More information on Ibrance Ibrance This page was last updated on 28/10/2026
关注理由：这篇肿瘤学内容涉及临床试验，适合了解研究正在回答什么问题，试验阶段和主要终点需以原文为准。
Derek Lowe · In the Pipeline 操纵Warburg效应：线粒体表达假单胞菌D-丙氨酸脱氢酶生成丙酮酸，减缓体外肿瘤细胞增殖
研究者在细胞线粒体基质表达来自假单胞菌的D-丙氨酸脱氢酶，加入D-丙氨酸使肿瘤细胞线粒体内直接生成丙酮酸（Grubaw系统），恢复氧化代谢。该体外操作使患者来源黑色素瘤细胞等增殖减慢、DNA复制与增殖相关基因受抑；HeLa细胞反将线粒体内多余丙酮酸排出胞外，转运通路未知。研究证实肿瘤细胞得益于Warburg效应下的糖酵解转换，线粒体活动本身即可下调肿瘤细胞增殖。
PubMed · Endocrine Reviews 肿瘤学：Overlapping roles of dysregulated glycolysis in the pathophysiology of diabetes and cancer.
原文摘录：Emerging evidence highlights a strong association between type 2 diabetes (T2D) and increased cancer risk, with partially overlapping metabolic disruptions potentially driving both diseases.
PubMed · Cancer Letters 临床前研究：MUC16 驱动胰腺癌中巨噬细胞介导的免疫抑制
研究者用 KPC 及 KPC-MUC16 敲除基因工程与原位小鼠模型发现，MUC16 缺失显著降低肿瘤负荷，减少 CD206+ 和 Ym1/2+ M2 样巨噬细胞、提高 M1/M2 比值并改善生存。
PubMed · Neuropharmacology 小白菊内酯通过激活GSK3β-抑制CREB信号下调transgelin-2抑制胶质母细胞瘤恶性进展的机制研究
一项体外与动物研究显示，从药用植物小白菊提取的倍半萜内酯parthenolide（Pt）可诱导人U-87MG和T98G胶质母细胞瘤细胞凋亡、抑制干性和侵袭，并在雄性NOD-SCID小鼠原位GBM模型中增强替莫唑胺（TMZ）疗效。
PubMed · The Journal of Experimental Medicine 肿瘤学：Colorectal cancers with distinct metastatic potential trigger divergent early T cell responses.
原文摘录：Colorectal cancer (CRC) remains a leading cause of mortality, with most cases refractory to immunotherapy. Distinguishing tumor-induced from steady-state mucosal T cell responses represents a critical barrier to understanding CRC immunity.
PubMed · Frontiers in Immunology 食管鳞癌回顾性队列：EDRIC相关免疫损伤中介约三分之一ENI照射策略的生存劣势
一项纳入279例接受根治性同步放化疗食管鳞癌患者的回顾性队列研究（2011–2015）显示，ENI较IFI显著升高EDRIC（8.17 vs 7.42 Gy；P=0.01），高EDRIC（>7.8 Gy）独立预示更差OS（HR=1.746；P<0.001）。
PubMed · Oncogene Oncogene 发表观点文章：肿瘤微环境的记忆、表观遗传疤痕与治疗复发的滞后逻辑
Kokkanti 等在 Oncogene 发表观点性论述，提出肿瘤微环境（TME）记忆概念，认为慢性炎症、代谢应激、治疗压力和细胞外基质重塑可在癌细胞与基质细胞中留下持久表观遗传与结构印迹，形成依赖历史的表型。
Derek Lowe · In the Pipeline精选 Derek Lowe解读intismeran autogene联合Keytruda黑色素瘤术后III期中期结果：复发或死亡风险降低42%
Merck与Moderna公布intismeran autogene联合Keytruda治疗黑色素瘤术后患者的III期中期结果：中位随访两年，联合组复发或死亡风险较Keytruda单药降低42%，两年未复发率为82.2%对70%，主要终点无复发生存期达到。
关注理由：该评论将泄露后公布的III期中期数据与II期结果及Keytruda单药两年基线对照，指出总生存期尚未成熟、膀胱癌与肾细胞癌数据未读出，有助于把疗效信息与资本市场波动分开看待。
PubMed · Cancer Letters 早期抑制WEE1可阻止MYC-high胶质母细胞瘤TMZ耐药细胞的衰老样表观重编程并与替莫唑胺协同（临床前研究）
研究者发现胶质母细胞瘤中一部分MYC-high肿瘤细胞在替莫唑胺（TMZ）早期暴露后存活，形成具有竞争性生存优势的先驱耐药（P-R）细胞，其经H3K27ac超增强子获得与染色质关闭两条通路的衰老样表观重编程。
PubMed · Molecular and Cellular Biology 肿瘤学：CBL Dysregulation in Cancer: Mechanisms of Oncogenic Signaling and Therapeutic Potential.
原文摘录：CBL is a multifunctional protein with E3 ubiquitin ligase and adaptor capacities, critical to regulating tyrosine kinase signaling pathways.
PubMed · Gene 骨桥蛋白（OPN）原初转录本在肿瘤细胞系中经反向剪接生成外显子circRNA的实验研究
研究者在TPC1、8505c、Caco-2、HT-29、HCT-116、RS4;11、Jurkat和LNCaP等多种肿瘤细胞系中，通过跨OPN外显子-外显子剪接接合区的发散引物结合RT-PCR和RT-qPCR，首次检测到OPN编码外显子2至7经反向剪接形成的外显子circRNA，且表达谱呈细胞类型特异。
PubMed · Biochemical and Biophysical Research Communications 肿瘤学：A novel anti-PD-1/VEGF bispecific fusion protein with enhanced VEGF binding capacity and developability for synergistic immunotherapy.
原文摘录：Combination therapy targeting PD-1 and VEGF has demonstrated significant clinical benefits in multiple cancers. However, developing a single-molecule bispecific agent capable of simultaneously blocking both pathways with enhanced VEGF-binding capacity rem … These findings highlight PKVBP as a promising bispecific candidate with superior VEGF-blocking capability and favorable developability, supporting its further investigation for synergistic cancer immunotherapy
PubMed · Journal of Medicinal Chemistry 肿瘤学：Structure-Based Design of HDAC6 Inhibitors Targeting the L2 Pocket: Modulating Autophagy and Liquid-Liquid Phase Separation in Lung Cancer.
原文摘录：We herein describe the structure-based design, synthesis and biological evaluation of a new class of histone deacetylase 6 (HDAC6) inhibitors guided by X-ray crystal structures of our previously identified compounds 13-15.
PubMed · Oncogene Oncogene发表研究：肝细胞癌细胞FATP5缺失经肿瘤相关内皮细胞内长链脂肪酸蓄积与PPARγ–CXCL12轴塑造促肿瘤微环境
研究发现肝细胞癌（HCC）细胞中脂肪酸转运蛋白5（FATP5）广泛下调，恶性细胞摄取长链脂肪酸（LCFAs）减少，过剩LCFAs被动蓄积于邻近的FATP3+肿瘤相关内皮细胞（TECs），激活PPARγ并旁分泌CXCL12，后者经CXCR4诱导浸润CD8+T细胞PD-1表达与终末耗竭，形成免疫抑制微环境并损害内皮屏障、增加血行转移风险。
PubMed · Cancer Letters 食管鳞癌中超级增强子驱动circPRRC2B稳定TALDO1维持氧化还原稳态的机制研究
研究者在食管鳞癌（ESCC）中鉴定出超级增强子（SE）经ETS1和HuR调控驱动的新型环状RNA circPRRC2B。体内外实验显示circPRRC2B而非PRRC2B促增殖、侵袭和转移，其机制为结合TALDO1并经BAP1去泛素化稳定TALDO1，激活磷酸戊糖通路、升高谷胱甘肽并抑制线粒体活性氧，维持氧化还原平衡；靶向circPRRC2B的反义寡核苷酸显著抑制ESCC生长。
EMA · News and Safety Reviews精选 肿瘤学：EMA recommends authorisation of Rasonque for metastatic pancreatic cancer
原文摘录：Image credit: © Chinnapong | stock.adobe.com EMA recommends authorisation of Rasonque for metastatic pancreatic cancer 15 October 2026 Phased review fast tracks assessment of medicine addressing unmet medical need News Human Innovation Medicines EMA’s hum … eu All other enquiries Please submit your request via the online form Follow us on Bluesky Related medicine information Rasonque
关注理由：这条肿瘤学内容涉及相关临床或研究问题，建议查看原文中的方法与适用范围。
PubMed · Biochimica et Biophysica Acta (BBA) - General Subjects 食管鳞癌衰老相关基因GREM2和PIK3C2G的鉴定与功能验证研究
一项整合TCGA-ESCC转录组数据与细胞衰老相关基因库、并在GSE20347队列独立验证的研究鉴定出GREM2和PIK3C2G为食管鳞癌（ESCC）衰老相关候选基因。
PubMed · Archives of Biochemistry and Biophysics 肿瘤学：The p.V27A variant of l-asparaginase II minimizes glutaminase activity without compromising anti-leukemic function.
原文摘录：l-Asparaginase is a fundamental chemotherapeutic agent for acute lymphoblastic leukemia (ALL) that depletes circulating asparagine to induce apoptosis in leukemic blasts. … V27A variant delivers an improved safety profile without compromising therapeutic potency, emerging as
PubMed · European Journal of Medicinal Chemistry SMP-656：基于自催化开环水解连接子的HER2靶向ADC临床前研究报告增强稳定性与抗肿瘤活性
研究者报告SuperHydra自水解马来酰亚胺连接子并构建HER2靶向ADC SMP-656（抗体Inetetamab偶联微管抑制剂Eribulin），在多种HER2阳性移植瘤模型中显示血浆稳定性提升与持久抗肿瘤活性，并在DS-8201a耐药模型中保留活性。食蟹猴中显示良好药代动力学与可接受的安全性。结果处于临床前阶段，研究支持其后续临床评估，DOI见PubMed PMID 42826516。
PubMed · British Journal of Pharmacology tinlarebant拮抗视黄醇结合蛋白4(RBP4)的结构与生化机制研究（临床前）
Bassetto等在British Journal of Pharmacology发表临床前研究，用荧光光谱、晶体结构和分子筛色谱阐明tinlarebant竞争性置换holo-RBP4中的视黄醇（IC50 8.75 ± 0.38 nM），使RBP4无法与transthyretin结合；小鼠单次给药后血浆RBP4水平最多降低93%。
PubMed · Physiological Reviews Physiological Reviews发表综述：单羧酸转运蛋白（MCT）的生理功能与在癌症中的作用及临床转化前景
Physiological Reviews发表综述，系统阐述单羧酸转运蛋白（MCT）在pH调节、氧化还原平衡和能量稳态中的生理作用，以及MCT1和MCT4在癌细胞中过表达与侵袭性行为、不良预后和治疗耐药的关联。文中介绍MCT抑制剂的开发进展，其中一种已进入早期临床评估，并讨论肿瘤微环境重塑、预后影响及靶向MCT的转化障碍与精准肿瘤学方向。
PubMed · Free Radical Biology and Medicine 靶向胆固醇合成通路诱导氧化应激可增强硼替佐米在多发性骨髓瘤中的疗效（临床前研究）
一项发表于Free Radical Biology and Medicine的研究（PMID 42767467）报告，多发性骨髓瘤（MM）细胞通过SREBF2激活的胆固醇生物合成积累7-脱氢胆固醇（7-DHC），减轻硼替佐米（BTZ）诱导的ROS细胞毒性，高胆固醇合成活性见于BTZ不反应浆细胞并与不良预后相关。
PubMed · International Journal of Cancer 结直肠癌MAEL表达研究因图像问题被《International Journal of Cancer》撤稿
International Journal of Cancer 撤回 2016 年发表的 MAEL 表达与结直肠癌上皮-间质转化及干细胞特性研究（DOI: 10.1002/ijc.30388），撤稿于 2025 年 7 月 30 日在线发布。
PubMed · Brain Research 肿瘤学：Alzheimer's disease-associated transcriptional signatures define prognostic subtypes in glioma.
原文摘录：BACKGROUND: Gliomas are molecularly heterogeneous central nervous system tumors with marked variation in clinical outcome. Alzheimer's disease (AD)-associated transcriptional alterations may capture neural and immune programs relevant to glioma biology, b … HPA observations provide orthogonal public-database support for selected signature components, while
中国医学科学院／北京协和医学院 · 院校报道 中国医学科学院血液病医院程涛、朱平、高欣团队在Protein & Cell在线发表人类生命全程血细胞单细胞转录组图谱研究并构建泛血液肿瘤预后评估框架
中国医学科学院血液病医院程涛、朱平、高欣团队2026年9月8日在Protein & Cell在线发表研究（DOI:10.1093/procel/pwag064），整合约百万个单细胞转录组数据，基于覆盖胎儿至老年五个生命阶段的207例健康个体，构建涵盖96个血细胞亚群的生命全程血液细胞图谱。
PubMed · The Journal of Pathology 肿瘤学：Heterozygous germline deletion in Hif3a exacerbates esophageal squamous cell carcinoma development.
原文摘录：Germline variations contribute to esophageal squamous cell carcinoma (ESCC) susceptibility. We identified a germline deletion (exons 7-8) in HIF3A in an ESCC family and investigated its functional impact using CRISPR/Cas9-engineered cells and Hif3a-eKO1 m
PubMed · Human Pathology精选 肿瘤学：Histologic patterns of metastatic lymph nodes and recurrence patterns in resected pN1-2 lung adenocarcinoma.
原文摘录：AIMS: Histologic grading of the primary tumor (PT) is an established prognostic factor in lung adenocarcinoma; however, the clinical relevance of histologic patterns in metastatic lymph nodes (MLNs) remains unclear. … These findings suggest that MLN morphology may provide complementary pathological information regarding patterns of locoregional recurrence after surgical resection
关注理由：关于肿瘤学的这条内容有明确出处，主要发现和适用人群可在原文中继续核查。
PubMed · Human Pathology 肿瘤学：Neuroendocrine cell proliferation in gastric and gastroesophageal carcinomas following neoadjuvant therapy: Frequency and association with clinicopathological parameters and prognosis.
原文摘录：OBJECTIVE: This study aimed to determine the frequency of neuroendocrine cell proliferation (NCP) in the tumor bed and adjacent mucosa in gastric and gastroesophageal junction carcinomas that had received neoadjuvant therapy, and to elucidate its prognost … However, further investigation is required to explore the cause of this proliferation
PubMed · Human Pathology 肿瘤学：Duct Quest: An international survey of genitourinary and community pathologists reveals diagnostic uncertainties in separating atypical intraductal proliferation from high-grade prostatic intraepithelial neoplasia and intraductal carcinoma of the prostate.
原文摘录：Atypical intraductal proliferations of the prostate encompass a spectrum from high-grade prostatic intraepithelial neoplasia (HGPIN) to intraductal carcinoma of the prostate (IDCP), the latter being strongly associated with aggressive prostate cancer. … These findings highlight persistent interobserver variability and the need for clearer diagnostic criteria, education, and further biological characterization of AIP and IDCP