跳到正文
>hotmap_
只看医学研究
11月5日周四
  1. PubMed · Nature Medicine

    医学研究：Opposing microbiome-mediated axes link modifiable lifestyles to health and chronic diseases.

    原文摘录：Analyses disentangling the role of the gut microbiome in linking lifestyle factors to health outcomes remain limited. Here, using fecal shotgun metagenomics from 6,803 adults in the Japanese 4D cohort, we identified two opposing microbiome-mediated axes l … We identify the gut microbiome as a key mediator linking lifestyle to health and disease, providing a framework for microbiome-based assessment to guide lifestyle interventions for health promotion and disease prevention

  2. PubMed · Critical Care Medicine

    感染病学：Long-Term Mortality in Sepsis Survivors: A Population-Based Study During 15 Years.

    原文摘录：OBJECTIVES: To evaluate long-term mortality among sepsis survivors in Catalonia over a 15-year period and to identify factors associated with increased mortality within 2 years after hospital discharge. DESIGN: Retrospective population-based cohort study.

    关注理由：这篇感染病学队列研究资料适合了解长期变化，研究对象、随访方式和结局指标建议一起查看。

  3. PubMed · Cell Death and Differentiation

    ENPP1 抑制 cGAS-STING 通路介导 EGFR-TKI 耐药非小细胞肺癌的免疫逃逸

    研究者在奥希替尼耐药肿瘤模型中发现 ENPP1 显著上调，其通过水解胞外 cGAMP 抑制免疫细胞 cGAS-STING 通路、削弱免疫激活，促进免疫抑制与肿瘤进展；基因敲除或药物抑制 ENPP1 在体外和体内增强免疫细胞对耐药肿瘤的杀伤，配对临床样本亦显示耐药后 ENPP1 表达升高。

  4. PubMed · Journal of Pharmaceutical Sciences

    光学相干断层扫描（OCT）作为口膜制剂的过程分析技术研究：离线到在线连续监测膜厚

    一项工艺分析技术研究评估了光学相干断层扫描（OCT）在口膜制剂生产中监测膜厚的表现。OCT 离线可分辨气泡、不溶性夹杂物和双层膜层间界面，在线模式下能解析泵速、涂布刀高度和衬纸速度变化引起的厚度波动，覆盖三种聚合物成膜材料；OSeeT Pharma 1D 传感器可连续输出厚度、粗糙度和均匀性且无需后处理。

  8. PubMed · Oncotarget

    DUSP4敲低抑制BRAF V600E突变结直肠癌模型增殖但经DUSP5适应性反馈限制疗效

    研究者在体外和体内BRAF V600E突变及BRAF抑制剂耐药结直肠癌模型中显示，DUSP4敲低诱导G1期细胞周期阻滞并减少增殖，同时引发部分由DUSP5介导的适应性反馈反应。治疗达到肿瘤停滞但未见肿瘤缩小，提示DUSP4作为单药靶点的疗效可能有限。文章为开放获取，发表于Oncotarget（PMID: 42985965）。

  9. PubMed · Journal of Clinical Epidemiology

    成人患者偏好系统综述方法学质量的meta研究：110篇综述多数评级极低或低，证据图谱归纳17项影响因素

    一项方法学伞式综述与证据图谱研究检索9个数据库至2026年4月10日，纳入110篇直接收集成人患者偏好的系统综述，以AMSTAR 2评估质量。结果显示70.9%被评为极低质量、25.5%低、2.7%中等，仅1篇（0.9%）为高质量；最常报告的偏好影响因素为疗效（67.3%）、不良作用/并发症风险（65.5%）和费用（50.0%），证据集中于治疗管理领域和癌症。

  10. PubMed · The Lancet Infectious Diseases

    病例报告：特立妥单抗（teclistamab）治疗骨髓瘤患者发生淋巴细胞脉络丛脑膜炎病毒脑膜脑炎，联合抗病毒治疗改善

    《The Lancet Infectious Diseases》报道英国一例复发多发性骨髓瘤患者在接受双特异性抗体teclistamab治疗后发生淋巴细胞脉络丛脑膜炎病毒（LCMV）脑膜脑炎，经脑脊液宏基因组二代测序确诊，并有家养啮齿类动物接触史。

  11. PubMed · Nature Medicine

    心血管医学：Digital readiness for cardiovascular care in high-burden US communities with cardiology workforce constraints.

    原文摘录：Digital health may extend cardiovascular care in communities with limited specialist access, but its effectiveness depends on whether communities have the infrastructure, devices, affordability, and capacity needed to use digital services. … These findings provide a national framework for distinguishing communities where digital cardiovascular care may be deployed from those where infrastructure and adoption support may first be needed to enable equitable implementation

  12. PubMed · Environmental Toxicology and Chemistry

    多菌灵水环境持久性评估研究：光敏剂与表面活性剂促进光化学降解（Environmental Toxicology and Chemistry）

    一项环境化学实验研究在含硝酸盐、溶解性有色有机物（CDOM）、铁及非离子表面活性剂的水体系中开展36组受控辐照实验，发现多菌灵（carbendazim）降解被显著促进，一级降解速率最高达9.68×10⁻² d⁻¹，推算环境半衰期在瑞典南部低光照下为75天，FOCUS定义的最晴朗欧洲地点约46天；界面富集是光敏转化前提，碳酸氢盐则抑制降解。

  13. PubMed · Hepatology

    ATTEST 2027：按证据风险分层的AI使用透明度框架（观点/方法提案）

    该文提出ATTEST框架，按后果将科研工作流中的AI辅助（从文献综合到病理分类、因果推断等八类功能）划分为低、中、高、极高四个风险层级，并配套投稿时的声明清单、按功能设定的最低报告标准及审稿人和编辑义务，旨在让读者、审稿人和编辑能评估AI对证据生成的影响。该框架为提案性质，未涉及临床疗效数据。

  14. PubMed · The Journals of Gerontology Series A

    老年人跌倒风险增加药物（FRIDs）去处方化的实施挑战与概念框架：来自 DeFRID 多中心随机对照试验及全球证据的叙述性综述

    印度 DeFRID 多中心随机对照试验（评估基于 Assess、Review、Minimize、Optimize、Reassess 的去处方化干预对比常规照护，纳入≥60岁使用FRIDs的老年人）团队发表叙述性综述，结合2025年12月前全球RCT证据与DeFRID过程评估数据。

  15. PubMed · Current Biology

    研究显示非三唑类农用杀菌剂可间接选择烟曲霉三唑耐药性

    荷兰研究团队在草丛中宇宙中竞争烟曲霉分离株，发现与农用残留浓度相当的DMI、SDHI和QoI类低浓度杀菌剂均独立提高三唑耐药等位基因比例，且非DMI耐药等位基因本身无交叉耐药，提示共存源于连锁的基因组搭便车效应。仅含非DMI杀菌剂的环境样本堆表型三唑耐药率超过20%。研究提示管理环境三唑耐药需考虑所有杀菌剂类别。

  18. PubMed · Nature Genetics

    深度生成模型 CORAL 用于空间组学多尺度多模态整合并发表于 Nature Genetics

    研究者开发 CORAL，一种基于图注意力的概率深度生成模型，整合空间转录组、蛋白组、代谢组与表观基因组数据，生成兼具高空间分辨率和广分子覆盖的统一表征。在合成与多组织实验数据中，CORAL 可识别空间域、预测高分辨率分子谱并推断细胞间相互作用；应用于肝细胞癌患者免疫治疗前后的空间转录组与蛋白组数据时，识别出与治疗耐药相关的免疫细胞亚群和信号通路。

  19. PubMed · American Journal of Epidemiology

    妇产科学：Neighborhood deprivation and the risk of stillbirth in New York.

    原文摘录：Stillbirth (fetal death ≥ 20 weeks gestation) occurs in approximately 21,000 births each year in the United States. Previous studies have observed associations between neighborhood deprivation and adverse perinatal outcomes. … Our findings highlight that women residing in the most deprived NDI quartile could benefit from enhanced prenatal services and support

  20. PubMed · The Lancet Oncology

    Pumitamig 联合白蛋白结合型紫杉醇一线治疗晚期三阴性乳腺癌的单臂 Ib/II 期试验报告活性与安全性

    一项在中国十家中心开展的单臂 Ib/II 期试验（ChiCTR2200060400，NCT05918133）评估 pumitamig（靶向 PD-L1 与 VEGF-A 的双特异性抗体）联合白蛋白结合型紫杉醇一线治疗不可切除局部晚期或转移性三阴性乳腺癌，42 名中国女性患者入组，主要终点为确认客观缓解率与安全性。

  29. PubMed · Transplantation

    动物与体外研究提示Piezo1介导的钙信号参与肺移植缺血再灌注损伤中的上皮损伤

    一项结合公共转录组数据、大鼠肺移植与体外氧糖剥夺/复氧模型的研究提示，机械敏感离子通道Piezo1在肺缺血/再灌注损伤（IRI）后上调，伴随肺上皮细胞凋亡、钙超载和线粒体膜电位去极化。Piezo1沉默或抑制可减轻钙积累、减少凋亡信号并改善细胞活力，而Yoda1激活可部分恢复损伤表型。结果提示Piezo1可能是肺移植IRI上皮损伤的潜在调控靶点，但仍属临床前证据。

  30. PubMed · Cell stem cell

    基于DNA甲基化的表观基因组编辑在人造血干细胞中诱导可逆基因沉默并调控血小板功能

    研究者在原代人造血干细胞（HSC）中以RNA瞬时递送基于DNA甲基化的表观基因组编辑器，靶向血小板整合素β3（ITGB3）诱导可遗传基因沉默，沉默经长期自我更新与巨核细胞分化持续存在，并使体外来源血小板聚集受损，该位点靶向去甲基化可部分逆转。

  31. The Lancet · Online

    妇产科学：[Comment] Inclusion of pregnant and lactating women in the Tumaini vaccine efficacy trial: a landmark advance

    原文摘录：The Tumaini trial protocol (NCT07842107) developed by the National Institute of Biomedical Research of the Democratic Republic of the Congo and partners to evaluate the efficacy of vaccines against Bundibugyo virus (BDBV) includes pregnant and lactating w

    关注理由：这篇妇产科学内容涉及具体研究方向，原文中的样本、结局和限制有助于理解其价值。

  32. The Lancet · Online

    肾脏病学：[Articles] Preparing for responsive management versus renal dialysis in older people living with kidney failure and frailty or multimorbidity in the UK (Prepare for Kidney Care): a two-arm, superiority, parallel-group, open-label, pragmatic, phase 3, individually randomised controlled trial

    原文摘录：Among older people living with kidney failure and frailty or multimorbidity, we found no evidence that either preparing for responsive management or preparing for renal dialysis was superior in terms of QALYs over a mean follow-up duration of 4·5 years.

    关注理由：关注肾脏病学时，这项随机对照研究可提供直接比较的证据，主要终点和研究局限需要一起阅读。

  33. The Lancet · Online

    肿瘤学：[Seminar] Retinoblastoma

    原文摘录：Retinoblastoma, the most common primary intraocular malignancy of childhood, represents a substantial global health equity concern, exemplifying profound disparities in global burden and outcome despite being a largely curable cancer. … approximately half of these cases instead show high-level amplification of the MYCN oncogene

  34. The Lancet · Online

    医学研究：[Comment] Left main coronary artery disease: PCI or CABG for revascularisation strategy

    原文摘录：Clinical guidelines generally favour coronary artery bypass grafting (CABG) over percutaneous coronary intervention (PCI) as the revascularisation strategy of choice in patients with left main coronary artery disease. … 3 The PRECOMBAT trial4 and SYNTAX Extended Survival trial5 similarly demonstrated no significant differences in all-cause mortality at 10 years between patients who underwent PCI with first-generation drug-eluting stents and those who underwent CABG

    关注理由：如果关注医学研究，这项随机对照研究的分组方式、主要终点和组间差异值得细读。

11月4日周三
  3. PubMed · Journal of Biological Chemistry

    靶向CLDN3破坏NF-κB/p65-CXCL1-PD-L1轴增强抗PD-1疗效：胃癌临床前研究发表于Journal of Biological Chemistry

    研究者报告CLDN3在胃癌组织中上调，与不良预后及肿瘤内CD8+ T细胞浸润减少相关，并通过促进p65磷酸化入核增强CXCL1转录、以CXCL1依赖方式上调PD-L1，介导免疫逃逸；研究基于临床队列、体外、体内及多组学分析（PMID 42982193）。

  4. WHO · Official News OData

    内分泌与代谢：One in four adolescents worldwide reported no active days in the previous week

    原文摘录：One in four adolescents worldwide reported not getting at least 60 minutes of physical activity on any day in the previous week. … Stand with science”, the theme of World Health Day 2026, marks a year-long campaign to highlight science as the foundation for protecting health and well-being worldwide

    关注理由：这条内分泌与代谢资料适合作为深入阅读入口，尤其要关注研究方法与结论是否匹配。