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9月19日周六
  1. PubMed · The American Journal of Cardiology

    心血管医学:Long-Term Outcomes of Intravascular Ultrasound-Guided Versus Angiography-Guided Percutaneous Coronary Intervention for Noncomplex Atherosclerotic Lesions.

    原文摘录:Intravascular ultrasound (IVUS) is a diagnostic modality providing information about lesion characteristics and optimizing results of percutaneous coronary intervention (PCI). … The results should be considered hypothesis generating and larger randomized studies with longer follow-up periods may be needed to further characterize the long-term sequelae of IVUS-guided versus angiography-guid

    关注理由:这条心血管医学内容涉及随机对照研究,建议同时核对纳入人群、主要终点与报告结果。

  2. PubMed · American Journal of Physiology-Gastrointestinal and Liver Physiology

    小鼠肝细胞Neogenin-HJV轴协同调控hepcidin表达:敲除模型显示约84%的hepcidin表达依赖二者协同

    研究用多种基因敲除小鼠模型揭示肝脏Neogenin(Neo1)与hemojuvelin(Hjv)协同调控铁调素hepcidin表达的机制。结果发现约84%的hepcidin表达依赖Neo1与Hjv的协同作用,Hjv独立诱导能力仅约12%,Neo1约3%;Neo1主要作为分子支架,经Hjv促进hepcidin诱导信号复合物组装,二者构成维持铁稳态的关键功能轴。

9月18日周五
  1. PubMed · Brain Research

    肿瘤学:Alzheimer's disease-associated transcriptional signatures define prognostic subtypes in glioma.

    原文摘录:BACKGROUND: Gliomas are molecularly heterogeneous central nervous system tumors with marked variation in clinical outcome. Alzheimer's disease (AD)-associated transcriptional alterations may capture neural and immune programs relevant to glioma biology, b … HPA observations provide orthogonal public-database support for selected signature components, while

  2. PubMed · The American Journal of Cardiology

    心血管医学:Impact of Side Branch Wire Jailing on Outcomes of Provisional Bifurcation Percutaneous Coronary Intervention: Insights from the PROGRESS-BIFURCATION Registry.

    原文摘录:Side branch (SB) wire jailing before main vessel (MV) stenting is widely used during provisional bifurcation percutaneous coronary intervention, but its benefit remains unclear. … In conclusion, wire jailing of the SB was associated with higher technical and procedural success and lower rates of final SB occlusion, with similar in-hospital and long-term MACE

    关注理由:这条心血管医学资料涉及具体临床问题,研究人群、方法和结局指标可以结合原文进一步查看。

9月17日周四
  1. PubMed · Neuroscience Letters

    精神医学:Single-housed, but not pair-housed, male and female rats demonstrate social conditioned place preference.

    原文摘录:Understanding the factors that modulate social reward has important implications for conditions characterized by social dysfunction, including autism spectrum disorder and social anxiety disorder. … These findings indicate that housing condition modulated sCPP expression in adult male and female rats

  2. PubMed · Journal of Psychosomatic Research

    行业资料:Brain training that cured a real illness: First-person testimony about fully recovering from myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) using the lightning process.

    原文摘录:I was medically diagnosed with ME/CFS. After being ill for five years, I fully recovered by retraining my brain. By 'brain training', I mean roughly the repetition of mental exercises with bodily movements that function to rewire neural pathways to improv … I also reflect as a philosopher on why I was not to blame for being ill and address a skeptical social trend that would deny testimony like mine

9月16日周三
  1. PubMed · Spine

    外科与麻醉:Perioperative Aspirin Continuation is Not Associated With Increased Surgical Morbidity Following Minimally Invasive Anterior-to-Psoas Lumbar Fusion: A Propensity-Matched Analysis.

    原文摘录:STUDY DESIGN: Retrospective cohort study with propensity score matching. OBJECTIVE: To evaluate the impact of perioperative aspirin continuation on surgical and postoperative outcomes following minimally invasive anterior-to-psoas (MIS-ATP) lumbar fusion. … CONCLUSION

    关注理由:这篇外科与麻醉队列研究资料适合了解长期变化,研究对象、随访方式和结局指标建议一起查看。

9月15日周二
  1. Eric Topol · Ground Truths

    Eric Topol 对谈慕尼黑大学 Marios Georgakis:心脏病两项大型随机对照试验为何失败——ZEUS(IL-6 抑制剂)与 HORIZON(降 Lp(a) 药物)均未达主要终点

    Eric Topol 与慕尼黑大学 Marios Georgakis 对谈,解析两项心脏病大型安慰剂对照随机试验结果:针对炎症的 ZEUS(IL-6 抑制剂)与降 Lp(a) 药物 HORIZON 均未达到主要终点。两人认为心血管药物研发远未到尽头,心脏病仍是全球头号死因。两项结果目前仅以新闻稿形式公布,完整数据尚未正式发表。

9月14日周一
  1. PubMed · Spine

    外科与麻醉:Comparison of the Sagittal Age-Adjusted Score and the T4-L1PA Mismatch in Discriminating Proximal Junctional Kyphosis and Failure in Adult Spinal Deformity Surgery.

    原文摘录:STUDY DESIGN: Retrospective single-center study. OBJECTIVE: To compare the discriminative ability of the sagittal age-adjusted score (SAAS) and the T4-L1PA mismatch for proximal junctional kyphosis (PJK) and proximal junctional failure (PJF) after adult s … Correcting the lumbar

  2. 中国医学科学院/北京协和医学院 · 院校报道

    中国医学科学院血液病医院程涛、朱平、高欣团队在Protein & Cell在线发表人类生命全程血细胞单细胞转录组图谱研究并构建泛血液肿瘤预后评估框架

    中国医学科学院血液病医院程涛、朱平、高欣团队2026年9月8日在Protein & Cell在线发表研究(DOI:10.1093/procel/pwag064),整合约百万个单细胞转录组数据,基于覆盖胎儿至老年五个生命阶段的207例健康个体,构建涵盖96个血细胞亚群的生命全程血液细胞图谱。

9月13日周日
  1. PubMed · Neuroscience Letters

    妇产科学:Maternal separation reshapes layer-specific PV-PNN architecture in the mouse barrel cortex.

    原文摘录:Early-life adversity alters inhibitory circuit maturation across developing brain systems, but most studies have focused on corticolimbic regions involved in emotional and cognitive regulation. … This layer-specific pattern suggests that early-life stress may alter the timing or distribution of plasticity and stabilization within primary sensory circuits, with potential consequences for how tactile information is filtered and integrated during cortical maturation

9月11日周五
  1. PubMed · Journal of the Neurological Sciences

    506例动脉瘤性蛛网膜下腔出血患者脑血管痉挛预测因素的单中心多变量回顾性分析(Journal of the Neurological Sciences)

    一项单中心回顾性分析纳入506例动脉瘤性蛛网膜下腔出血(aSAH)成人患者,其中90例(17.7%)发生脑血管痉挛(CVS)。多变量logistic回归显示,年龄<52岁、去骨瓣减压术和脑积水与任何CVS独立相关;既往缺血性卒中和modified Fisher 3–4级与症状性CVS独立相关(modified Fisher 3、4级与任何CVS仅呈临界关联,p<0.10)。

9月10日周四
  1. PubMed · The Journal of Pathology

    《病理学杂志》发表单细胞RNA测序研究:移行区富集的WIF1+基底细胞亚群与良性前列腺增生相关

    一项对前列腺癌切除标本良性区域进行的单细胞RNA测序研究(发表于The Journal of Pathology)发现,表达WIF1、VCAN、NRG1等基因的基底细胞亚群显著富集于前列腺移行区,并经既往公开数据集证实其在良性前列腺增生(BPH)中较正常前列腺显著富集。

9月9日周三
9月7日周一
  1. PubMed · Spine

    医学研究:A Prospective Comparative Study of UBE-ULBD Versus Endo-ULBD for Lumbar Spinal Stenosis.

    原文摘录:STUDY DESIGN: Prospective, randomized controlled trial (RCT). OBJECTIVE: To directly compare the clinical and radiologic outcomes of unilateral biportal endoscopic unilateral laminotomy for bilateral decompression (UBE-ULBD) versus single-port endoscopic … Within the constraints of this study, both techniques represent viable options for minimally invasive decompression

9月3日周四
  1. PubMed · Neurobiology of Aging

    多中心尸检研究:阿尔茨海默病矿化血管的区域分布及临床病理学关联

    一项涵盖哥伦比亚大学、加州大学圣地亚哥分校和戴维斯分校三个阿尔茨海默病研究中心、共265例中/重度AD神经病理改变逝者的多中心尸检研究显示,矿化血管(MBV)在苍白球受累率最高(58.3%),其次为后部海马(28.6%)和壳核(13.8%),提示区域选择性。

9月2日周三
  1. PubMed · American Journal Of Pathology

    有氧运动经细胞外囊泡 miR-203a-3p 与 miR-133b-3p 减轻小鼠动脉粥样硬化巨噬细胞炎症与脂质蓄积(动物研究)

    动脉粥样硬化小鼠模型研究显示,有氧训练小鼠血浆来源的细胞外囊泡中 miR-203a-3p 与 miR-133b-3p 升高,主要源于骨骼肌,可分别靶向 Tlr4 和 Insr 抑制 NF-κB/NLRP3 信号,在体内外减轻巨噬细胞炎症与脂质蓄积并延缓动脉粥样硬化进展;miRNA 模拟物可重现、抑制剂可逆转该效应,提示潜在治疗策略。该结果来自动物与体外实验,临床意义尚待验证。

9月1日周二
  1. PubMed · Clinica Chimica Acta

    综述:GDF15作为心血管疾病新型生物标志物的作用——覆盖高血压、动脉粥样硬化、心力衰竭、肺动脉高压与冠心病

    一篇发表于Clinica Chimica Acta的综述系统分析生长分化因子15(GDF15,TGF-β超家族成员)在高血压、动脉粥样硬化、心力衰竭、肺动脉高压和冠心病五种心血管疾病中的差异表达、作用机制及预后预测功能。GDF15在炎症、氧化应激、组织损伤和缺氧时表达显著升高,循环水平升高与主要心血管疾病及不良预后密切相关。综述支持其作为心血管疾病新型生物标志物的价值,但未报告临床干预结果。

  2. PubMed · Clinica Chimica Acta

    综述:用于急性肾损伤早诊与即时检测的电化学免疫传感器(KIM-1与NGAL)研究进展(Clinica Chimica Acta)

    本综述总结基于电化学免疫传感器检测急性肾损伤(AKI)生物标志物KIM-1和NGAL(可测于血清和尿液)的近期进展,并比较各传感器的检测限等分析性能。作者指出目前仍需进一步研究,开发能在临床诊断AKI中被广泛接受的最优传感器,尤其是面向早期和即时检测的应用。

8月31日周一
  1. PubMed · Developmental Psychology

    1月龄婴儿脑电图静息活动与2年内社会情绪行为问题的前瞻性队列研究

    一项纳入185对母婴(53.51%女婴)的纵向观察研究发现,1月龄全脑静息脑电活动整体上不能显著预测12月龄时的社会情绪行为问题;但较高的全脑相对theta功率和较低的相对alpha功率显著预测24月龄时更多的社会情绪行为问题。研究还报告了探索性脑区分析,提示静息脑活动可能是多样化非临床样本中后期社会情绪问题的早期指标。

8月30日周日
  1. PubMed · Magnetic Resonance in Medicine

    伺服导航联合运行时稳定化相位均衡(PEERS)用于3D EPI fMRI时间序列的运动与相位校正方法研究

    一种用于fMRI时间序列的分段3D EPI序列结合短轨道导航器的伺服导航与回顾性数据驱动相位均衡(PEERS),在体模和体内评估中实现全自动、自校准的运动、体相位和频率校正。相比传统体积重对齐,PEERS在小运动时tSNR最高提升30%,受试者保持静止时约提升10%。作者指出稳定性增益能否转化为功能敏感性指标尚需足够统计效能的研究,本数据不支持相关结论。

8月29日周六
8月27日周四
  1. PubMed · Developmental Psychology

    初为父母阶段父母身份认同发展的四波纵向研究:与新手父母心理健康的关联(Developmental Psychology)

    一项覆盖孕期至育儿第2年的四波纵向研究纳入288对初为父母的夫妇,在每个时间点测量父母身份认同的承诺、探索、沉思性探索及心理健康。结果显示,身份承诺水平较高或增幅较大、沉思性探索较低或下降较多者,生活满意度更高且抑郁症状更低;探索维度与心理健康的关联较弱且不一致,并存在伴侣间效应,母亲与父亲间存在差异。

  2. PubMed · Journal of Ethnopharmacology

    天然植物化学物对抗多柔比星心脏毒性的临床前研究Meta分析发表于《Journal of Ethnopharmacology》

    一项遵循PRISMA指南、方案注册于PROSPERO(CRD420251050072)的系统综述与Meta分析纳入33项临床前研究共656只啮齿动物,评估传统药用植物来源天然植物化学物(如甘草黄酮、丹参萜类、人参皂苷)在多柔比星心脏毒性的动物模型中的心脏保护作用。

8月26日周三
8月25日周二
8月19日周三
8月18日周二
  1. PubMed · Human Pathology

    肿瘤学:Histologic patterns of metastatic lymph nodes and recurrence patterns in resected pN1-2 lung adenocarcinoma.

    原文摘录:AIMS: Histologic grading of the primary tumor (PT) is an established prognostic factor in lung adenocarcinoma; however, the clinical relevance of histologic patterns in metastatic lymph nodes (MLNs) remains unclear. … These findings suggest that MLN morphology may provide complementary pathological information regarding patterns of locoregional recurrence after surgical resection

    关注理由:关于肿瘤学的这条内容有明确出处,主要发现和适用人群可在原文中继续核查。

8月17日周一
  1. Europe PMC · 撤稿与关系监测

    精神医学:RETRACTED ARTICLE: Gatekeeping Mental Health Care: A Critical Analysis of mhGAP-HIG Implementation in Cameroon's Anglophone Crisis Through an Anti-Oppressive Lens.

    原文摘录:Ndze, Y. E. (2026). Gatekeeping Mental Health Care: A Critical Analysis of mhGAP-HIG Implementation in Cameroon's Anglophone Crisis Through an Anti-Oppressive Lens. Journal of Evidence-Based Social Work , 1-33. https://doi.org/10.1080/26408066.2026. … The retracted article will remain online to maintain the scholarly record, but it will be digitally watermarked on each page as 'Retracted'

    关注理由:这条精神医学资料涉及具体临床问题,研究人群、方法和结局指标可以结合原文进一步查看。