随机对照试验：简短认知行为治疗（BCBT）与当下中心治疗（PCT）中自杀意念各维度的动态变化模式差异
一项在高危美国军人和退伍军人中比较BCBT与PCT的随机对照试验中，研究者每次治疗时评估自杀意念量表（SSI）前5项，用连续时间多变量变化模型和特征分解分析各维度变化。结果显示两治疗中各维度变化速度不一，BCBT下维度变化更快且更同步，PCT变化更慢且一致性较低。这提示总分相近时，两种治疗减低自杀意念的过程可能存在质的差异。
#论文/研究
PubMed · Behaviour Research and Therapy PubMed · Food and Chemical Toxicology 香原料体外遗传毒性检测策略综述：应对假阳性并推进非动物方法（ToxTracker、3D RSMN、CEGA/HET-MN、OASIS TIMES）
一篇发表于 Food and Chemical Toxicology 的综述提出香原料的分 tier、机制导向全体外遗传毒性检测策略，整合 ToxTracker GFP 报告干细胞平台、3D 重建皮肤微核（RSMN）试验、鸡胚系统 CEGA 与 HET-MN，以及 OASIS TIMES 计算代谢预测，并给出决策流程图。
PubMed · Journal of Psychosomatic Research 两项相隔十年的横断面调查：多重躯体症状人群的自评健康、医疗利用与处方药使用变化
丹麦研究团队基于2012年和2022年各10万人随机样本的重复横断面调查（分析限于20–64岁受访者），用25项Bodily Distress Syndrome清单评估多重躯体症状，并通过全国登记链接分析医疗利用与处方药使用。
PubMed · Journal of Psychosomatic Research精选 消化与肝病：Personalized psychotherapy in irritable bowel syndrome: results from a pilot randomized controlled trial (PIONEER-IBS).
原文摘录：OBJECTIVE: Irritable bowel syndrome (IBS) is characterized by recurring gastrointestinal symptoms and substantial psychosocial burden. Despite the wide range of therapeutic options, no approach is consistently superior across patients. … However, the benefit of treatment allocation based on individual symptom dynamics, the validity of personalization approaches and the efficacy of EMDR in specific IBS subgroups represent distinct but intertwined questions that require further evaluation
关注理由：如果关注消化与肝病，这项随机对照研究的分组方式、主要终点和组间差异值得细读。
PubMed · Neurobiology of Aging 轻度创伤性脑损伤累积负担与退伍军人白质加速老化相关：横断面研究发表于Neurobiology of Aging
一项针对710名美国退伍军人（19-80岁，平均37岁）的横断面研究显示，轻度创伤性脑损伤（mTBI）累积负担越高，年龄与白质微结构完整性之间的负相关越陡。全束分析发现腹侧扣带束和视辐射存在mTBI与年龄的交互作用，沿束分析另在五条白质通路上发现交互聚集区。结果提示mTBI累积负担越高，急性期恢复后白质年龄相关退化越快，且损伤集中于特定束段；该研究为横断面设计，尚不能确立因果关系。
PubMed · American Heart Journal 多中心研究：左心发育不良综合征婴儿限制性房间隔伴一期姑息术前间隔干预的结局分析
一项基于 National Pediatric Cardiology Quality Improvement Collaborative 的多中心回顾性队列研究纳入2016–2024年70个中心3,644例接受一期姑息手术（S1P）的婴儿，其中164例（5%）为限制性/完整房间隔（RAS）且行术前间隔干预。
PubMed · American Heart Journal EXPORT 试验方案发表：持续房颤患者在肺静脉隔离基础上附加非肺静脉触发灶消融的多中心随机试验原理与设计
EXPORT 试验（NCT07197931）是一项多中心、前瞻性、优效性、单盲、盲法终点随机试验，拟纳入 430 例药物难治性持续性房颤首次消融患者，比较肺静脉隔离联合非肺静脉触发灶诱发、标测与消融与单纯肺静脉隔离。主要终点为 3 个月空白期后任何持续 ≥30 秒的房性心律失常记录，次要终点包括不使用抗心律失常药物的无复发、围术期并发症和总手术时间。本文为方案与设计，尚无结果数据。
PubMed · Arteriosclerosis Thrombosis and Vascular Biology 高代谢状态驱动人和小鼠MASLD血小板功能障碍的横断面与动物研究
一项横断面研究纳入单纯脂肪变（n=42）、脂肪性肝炎（n=28）、代谢相关肝硬化（n=16）及无脂肪变对照（n=23），发现MASLD早期即出现血小板分泌标志物升高和代谢活性增强；晚期MASH和肝硬化阶段血小板对G蛋白偶联受体刺激无应答，但对GPVI刺激反应增强，呈分泌和促凝表型。
Europe PMC · 撤稿与关系监测 外科与麻醉：Withdrawn as duplicate: Pulmonary Blood Volumes on CT Predict Residual Pulmonary Hypertension Post-Pulmonary Endarterectomy.
原文摘录：Pulmonary blood volumes (PBV), currently not assessed by computed tomography pulmonary angiography (CTPA), could provide additional information to routine investigations performed for chronic thromboembolic pulmonary hypertension (CTEPH). … Utilizing CTPA-derived PBV post-PEA to identify patients without residual PH can potentially reduce the need for routine postoperative right heart catheterization
PubMed · The Journal of Pathology 小鼠研究：髓系MrgprD通过NF-κB介导巨噬细胞M1极化驱动DSS急性结肠炎
小鼠研究显示，Mrgprd全身或髓系特异性敲除可减轻葡聚糖硫酸钠（DSS）诱导的急性结肠炎，表现为结肠长度保留、病理评分降低、屏障完整性改善及M1巨噬细胞比例下降，其作用强于神经元特异性敲除；机制上MrgprD经NF-κB信号促进结肠巨噬细胞促炎极化，生物信息分析支持MRGPRD-NF-κB轴与人类IBD相关。
PubMed · Pharmacology Biochemistry and Behavior 精神医学：Ayahuasca treatment reduces 50-kHz ultrasonic vocalizations and modifies mesocorticolimbic monoamine neurochemistry in rats.
原文摘录：Rats emit 50-kHz ultrasonic vocalizations (USVs), a widely used measure of drug-induced motivational and affective effects and dopaminergic activity. … Together, these findings suggest that AYA attenuates LDX-induced positive affective responses without reducing hyperlocomotion, accompanied by changes in noradrenaline and serotonin levels in the mPFC and dopamine levels in the NAc
PubMed · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy ATR-FTIR光谱联合差异表达基因与机器学习估计嗜尸蝇类滞育时长的研究
一项方法学研究以法医重要性蝇种Sarcophaga peregrina为模型，将基因表达与ATR-FTIR红外光谱特征融合，用于估计嗜尸昆虫滞育时长。转录组测序鉴定出14个具有时间动态的核心差异表达基因，qPCR验证后保留11个；数据融合经偏最小二乘降维和支持向量回归建模，测试R²=0.922，优于任一单独数据集。
PubMed · European Journal of Medicinal Chemistry SMP-656：基于自催化开环水解连接子的HER2靶向ADC临床前研究报告增强稳定性与抗肿瘤活性
研究者报告SuperHydra自水解马来酰亚胺连接子并构建HER2靶向ADC SMP-656（抗体Inetetamab偶联微管抑制剂Eribulin），在多种HER2阳性移植瘤模型中显示血浆稳定性提升与持久抗肿瘤活性，并在DS-8201a耐药模型中保留活性。食蟹猴中显示良好药代动力学与可接受的安全性。结果处于临床前阶段，研究支持其后续临床评估，DOI见PubMed PMID 42826516。
New England Journal of Medicine · Current Issue 内分泌与代谢：Retatrutide, a Triple Hormone Receptor Agonist, for Treatment of Obesity
原文摘录：New England Journal of Medicine, Volume 395, Issue 18, Page 1781-1793, November 5, 2026.
PubMed · British Journal of Pharmacology tinlarebant拮抗视黄醇结合蛋白4(RBP4)的结构与生化机制研究（临床前）
Bassetto等在British Journal of Pharmacology发表临床前研究，用荧光光谱、晶体结构和分子筛色谱阐明tinlarebant竞争性置换holo-RBP4中的视黄醇（IC50 8.75 ± 0.38 nM），使RBP4无法与transthyretin结合；小鼠单次给药后血浆RBP4水平最多降低93%。
PubMed · Pharmacology Biochemistry and Behavior 内分泌与代谢：Antidepressant potential of agmatine: Effects on hypothalamic neurogenesis in rats with depressive behavior.
原文摘录：This study aimed to investigate the behavioral, neuroendocrine, and hypothalamic molecular effects of agmatine in rats exposed to chronic mild stress (CMS). … These findings suggest that agmatine exerts selective antidepressant-like and neuroendocrine effects under chronic stress conditions and may modulate hypothalamic IGF1R- and NPY related pathways
PubMed · European Journal of Medicinal Chemistry 双重μOR/σ1R配体10q与13d的临床前发现：镇痛效力保留且hERG抑制降低
研究者在既往双靶点先导物4x因明显hERG抑制受阻的基础上，通过理性设计与结构修饰发现化合物10q和13d，保留μOR激动与σ1R拮抗活性并显著降低hERG抑制，扩大治疗窗口。两项化合物在体内显示较好的安全性、药代动力学特征和明显减轻的耐受性，被定位为进阶先导物。研究属临床前药物发现阶段，尚无患者临床证据。
PubMed · Psychiatry Research 美国全国性调查：亲历枪支自杀者更可能持枪且更常不安全储存
一项基于Ipsos Knowledge Panel概率抽样、加权反映美国人群的调查（N=7810）发现，27.8%的参与者认识死于枪支自杀的人；这种经历与持枪机会增加、对枪支风险认知增强以及不安全储存（不上锁）几率增加均相关。作者指出，仅靠认识死者的意识可能不足以促进安全储存，需其他干预手段。研究为横断面设计，仅提示关联，不构成因果结论。
PubMed · The Journal of Arthroplasty 骨科与运动医学：The Aggregation of Marginal Gains in Total Joint Arthroplasty: A Practical Framework for Scalable, High-Quality Care.
原文摘录：Demand for total hip and knee arthroplasties continues to increase faster than many programs can expand operating room capacity, clinic access, and workforce. … When used with appropriate safeguards, this approach may provide a practical and scalable model for total joint arthroplasty programs
PubMed · Carbohydrate Polymers 消化与肝病：Maltodextrin-shielded pumpkin seed protein nanoparticles formed by Maillard-induced protein modification for oral pterostilbene delivery.
原文摘录：Plant protein nanoparticles represent promising oral carriers for hydrophobic bioactives in functional foods, yet their poor dispersibility and gastrointestinal instability limit delivery efficacy. … Collectively, Maillard-induced MD conjugation generated a protein-core/carbohydrate-shell nanoarchitecture that enhanced PTE stability, gastrointestinal performance, and oral bioavailability
PubMed · Schizophrenia Research ABCD研究9476名青少年：右侧海马体积缩小与持续性痛苦性精神病样体验相关，团体运动参与或减弱该关联（Schizophrenia Research）
基于9476名青少年脑认知发展（ABCD）研究的纵向分析显示，10岁时右侧海马体积缩小与10–13岁持续性痛苦性精神病样体验（PLEs）几率升高相关（每增加1个标准差，aOR=0.91，95% CI 0.85–0.98）。
PubMed · Free Radical Biology and Medicine 靶向胆固醇合成通路诱导氧化应激可增强硼替佐米在多发性骨髓瘤中的疗效（临床前研究）
一项发表于Free Radical Biology and Medicine的研究（PMID 42767467）报告，多发性骨髓瘤（MM）细胞通过SREBF2激活的胆固醇生物合成积累7-脱氢胆固醇（7-DHC），减轻硼替佐米（BTZ）诱导的ROS细胞毒性，高胆固醇合成活性见于BTZ不反应浆细胞并与不良预后相关。
PubMed · Neuroscience Letters 急诊与重症医学：Prior trauma shapes the effects of psilocybin on stress sensitization in mice.
原文摘录：Exposure to traumatic events induces persistent alterations in defensive behavior that extend beyond associative fear memories, including heightened responses to novel stimuli (stress sensitivity) and sustained defensive states in neutral contexts (stress … This work highlights the importance of distinguishing between associative and non-associative components of fear and suggests that psychedelic-induced plasticity may amplify latent trauma-related states under certain conditions
PubMed · The American Journal of Cardiology 新型2-Hz冠脉血管内碎石导管治疗钙化冠脉病变：DISRUPT CAD Duo单臂研究一年结果发表
Matthew J Price等在《The American Journal of Cardiology》发表DISRUPT CAD Duo多中心、前瞻性、单臂研究的一年结果：145例新发重度钙化冠脉病变患者接受2-Hz血管内碎石（IVL）导管治疗，140例（97.9%）完成1年随访。
PubMed · The American Journal of Cardiology 血管内超声引导与非复杂病变造影引导经皮冠状动脉介入的单中心回顾性长期结局比较研究
一项单中心回顾性研究纳入2011年1月至2018年12月间1,700例接受非复杂动脉粥样硬化病变PCI的患者，采用逆概率加权调整混杂因素，比较IVUS引导与造影引导PCI的2年结局。主要终点MACE（全因死亡、Q波心肌梗死及靶血管血运重建复合）两组无显著差异（9.7% vs 11.5%，p=0.34），各组分差异亦不显著。作者指出结果属假说生成性质，需更大规模随机研究及更长随访验证。
PubMed · Free Radical Biology and Medicine 神经内科：Dysfunctional mitophagy in Alzheimer's disease: evidence from peripheral optineurin.
原文摘录：Mitophagy and mitochondrial quality-control pathways are impaired in Alzheimer's disease (AD), but the relevance of peripheral mitophagy markers and their regulation during sustained amyloid-β (Aβ) stress remain unclear.
PubMed · American Journal of Physiology-Gastrointestinal and Liver Physiology 小鼠肝细胞Neogenin-HJV轴协同调控hepcidin表达：敲除模型显示约84%的hepcidin表达依赖二者协同
研究用多种基因敲除小鼠模型揭示肝脏Neogenin（Neo1）与hemojuvelin（Hjv）协同调控铁调素hepcidin表达的机制。结果发现约84%的hepcidin表达依赖Neo1与Hjv的协同作用，Hjv独立诱导能力仅约12%，Neo1约3%；Neo1主要作为分子支架，经Hjv促进hepcidin诱导信号复合物组装，二者构成维持铁稳态的关键功能轴。
PubMed · Psychiatry Research 中国健康与养老追踪研究 couples 分析：衰弱与抑郁症状多轨迹模式与认知功能变化（Charls，2011–2020）
基于中国健康与养老追踪研究（CHARLS）2011–2020 年5828对夫妻的纵向数据，研究用组基轨迹模型（GBTM）识别出四种衰弱-抑郁联合轨迹组（G1–G4）。
PubMed · Brain Research 肿瘤学：Alzheimer's disease-associated transcriptional signatures define prognostic subtypes in glioma.
原文摘录：BACKGROUND: Gliomas are molecularly heterogeneous central nervous system tumors with marked variation in clinical outcome. Alzheimer's disease (AD)-associated transcriptional alterations may capture neural and immune programs relevant to glioma biology, b … HPA observations provide orthogonal public-database support for selected signature components, while
PubMed · The American Journal of Cardiology PROGRESS-BIFURCATION注册研究：边支导丝Jailing改善分叉PCI手术成功率但未改变长期MACE
该研究分析PROGRESS-BIFURCATION前瞻性全球注册中2013至2026年10个中心1,485例患者（1,628处病变）的临时策略分叉病变经皮冠状动脉介入数据，比较主支支架植入前行边支导丝Jailing与否的结局，其中818处病变（50.2%）采用Jailing。
PubMed · Neuroscience Letters 精神医学：Single-housed, but not pair-housed, male and female rats demonstrate social conditioned place preference.
原文摘录：Understanding the factors that modulate social reward has important implications for conditions characterized by social dysfunction, including autism spectrum disorder and social anxiety disorder. … These findings indicate that housing condition modulated sCPP expression in adult male and female rats
PubMed · Social Science & Medicine 性取向与英国食物不安全及食物银行使用障碍：基于 Understanding Society 2011–2025 纵向研究
基于 2011–2025 年英国家庭纵向研究 Understanding Society 的分析显示，双性恋、“其他”性取向及不愿披露性取向的成年人食物不安全调整后风险分别比异性恋成年人高 23%、66% 和 23%，同性恋/双性恋女性无显著差异。
PubMed · Spine精选 外科与麻醉：Perioperative Aspirin Continuation is Not Associated With Increased Surgical Morbidity Following Minimally Invasive Anterior-to-Psoas Lumbar Fusion: A Propensity-Matched Analysis.
原文摘录：STUDY DESIGN: Retrospective cohort study with propensity score matching. OBJECTIVE: To evaluate the impact of perioperative aspirin continuation on surgical and postoperative outcomes following minimally invasive anterior-to-psoas (MIS-ATP) lumbar fusion. … CONCLUSION
关注理由：这篇外科与麻醉队列研究资料适合了解长期变化，研究对象、随访方式和结局指标建议一起查看。
PubMed · Spine 外科与麻醉：Comparison of the Sagittal Age-Adjusted Score and the T4-L1PA Mismatch in Discriminating Proximal Junctional Kyphosis and Failure in Adult Spinal Deformity Surgery.
原文摘录：STUDY DESIGN: Retrospective single-center study. OBJECTIVE: To compare the discriminative ability of the sagittal age-adjusted score (SAAS) and the T4-L1PA mismatch for proximal junctional kyphosis (PJK) and proximal junctional failure (PJF) after adult s … Correcting the lumbar
中国医学科学院／北京协和医学院 · 院校报道 中国医学科学院血液病医院程涛、朱平、高欣团队在Protein & Cell在线发表人类生命全程血细胞单细胞转录组图谱研究并构建泛血液肿瘤预后评估框架
中国医学科学院血液病医院程涛、朱平、高欣团队2026年9月8日在Protein & Cell在线发表研究（DOI:10.1093/procel/pwag064），整合约百万个单细胞转录组数据，基于覆盖胎儿至老年五个生命阶段的207例健康个体，构建涵盖96个血细胞亚群的生命全程血液细胞图谱。
PubMed · Neuroscience Letters 妇产科学：Maternal separation reshapes layer-specific PV-PNN architecture in the mouse barrel cortex.
原文摘录：Early-life adversity alters inhibitory circuit maturation across developing brain systems, but most studies have focused on corticolimbic regions involved in emotional and cognitive regulation. … This layer-specific pattern suggests that early-life stress may alter the timing or distribution of plasticity and stabilization within primary sensory circuits, with potential consequences for how tactile information is filtered and integrated during cortical maturation
PubMed · Journal of the Neurological Sciences 506例动脉瘤性蛛网膜下腔出血患者脑血管痉挛预测因素的单中心多变量回顾性分析（Journal of the Neurological Sciences）
一项单中心回顾性分析纳入506例动脉瘤性蛛网膜下腔出血（aSAH）成人患者，其中90例（17.7%）发生脑血管痉挛（CVS）。多变量logistic回归显示，年龄<52岁、去骨瓣减压术和脑积水与任何CVS独立相关；既往缺血性卒中和modified Fisher 3–4级与症状性CVS独立相关（modified Fisher 3、4级与任何CVS仅呈临界关联，p<0.10）。
PubMed · The Journal of Pathology 《病理学杂志》发表单细胞RNA测序研究：移行区富集的WIF1+基底细胞亚群与良性前列腺增生相关
一项对前列腺癌切除标本良性区域进行的单细胞RNA测序研究（发表于The Journal of Pathology）发现，表达WIF1、VCAN、NRG1等基因的基底细胞亚群显著富集于前列腺移行区，并经既往公开数据集证实其在良性前列腺增生（BPH）中较正常前列腺显著富集。
PubMed · The Journal of Pathology 肿瘤学：Heterozygous germline deletion in Hif3a exacerbates esophageal squamous cell carcinoma development.
原文摘录：Germline variations contribute to esophageal squamous cell carcinoma (ESCC) susceptibility. We identified a germline deletion (exons 7-8) in HIF3A in an ESCC family and investigated its functional impact using CRISPR/Cas9-engineered cells and Hif3a-eKO1 m
PubMed · The Journal of Pediatrics 儿科学：School-Based Health and Health Care Utilization Among Rural Youth: Evidence from a School-Based Health Center Opening.
原文摘录：OBJECTIVE: To examine the effects of opening a school-based health center (SBHC) on primary and preventive care utilization among students in a rural setting.