抗精神病药初治首发精神病患者脑结构年龄轨迹的随机安慰剂对照研究
Alejandro Roig-Herrero 等在 Schizophrenia Research 发表的随机对照研究纳入61例抗精神病药初治首发精神病患者，随机接受第二代抗精神病药（利培酮或帕利哌酮）或安慰剂6个月治疗并配合强化社会心理治疗，另设27名健康对照。
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PubMed · Schizophrenia Research PubMed · Biochemical Pharmacology 丙磺舒体外促进猪逼尿肌松弛并增强环核苷酸升高剂的作用：《Biochemical Pharmacology》发表机制研究
一项体外猪逼尿肌组织研究显示，probenecid（丙磺舒）在1 nM–1 mM范围产生浓度依赖性松弛，最大反应为56%，并增强salbutamol、forskolin、riociguat、cilostazol和tadalafil诱导的松弛。
PubMed · ACS Applied Materials & Interfaces 脱细胞羊膜-骨髓间充质干细胞复合物改善小鼠角膜碱烧伤修复的机制研究
研究者构建脱细胞羊膜复合骨髓来源间充质干细胞（BMSC）的组织工程支架，在小鼠角膜碱烧伤模型中评估其疗效。与单纯羊膜移植或结膜下BMSC注射相比，该复合物更有效减轻角膜混浊与新血管形成、恢复上皮完整性，并降低活性氧和丙二醛水平、恢复线粒体氧化磷酸化（Seahorse检测，伤后14天效果更明显）。
ClinicalTrials.gov API v2 · 登记更新 肿瘤学：Hepatic Artery Infusion of Carfilzomib in Participants With Liver Metastatic Disease Previously Treated With Hepatic Artery Infusion Pump Therapy
原文摘录：Background: Cancers that begin in the colon, adrenal glands, or bile ducts may spread to the liver. These liver tumors are often treated using a hepatic artery infusion (HAI) pump.
PubMed · Carcinogenesis Carcinogenesis（致癌机制）综述：提出以测量为中心的框架刻画“癌症之前”的暴露组生物学状态
Carcinogenesis 期刊发表一篇综述，提出以测量为中心的框架，用组织生理、纵向生物标志物、遗传与表观遗传信息及内外暴露的定量评估，识别临床可检出癌症之前可能存在的生物学状态，区分短暂生理波动与以幅度、持续时间、可重复性和轨迹为特征的持续偏离。该框架强调这些过程并非癌症特异，不预设恶性进展为决定性，其转化仍需分析与临床验证、因果推断、纵向结局研究及过度诊断评估。
PubMed · Journal of Thoracic and Cardiovascular Surgery 主动脉瓣感染性心内膜炎主动脉根部脓肿单中心回顾研究：脓肿与不良预后相关，补片修复较扩大手术结局更佳
一项2019–2024年单中心回顾性研究纳入158例手术治疗的主动脉瓣感染性心内膜炎患者（57%合并主动脉根部脓肿），中位随访1.22年。根部脓肿与MACCE（校正HR 3.15, 95%CI 1.51–6.59, p=0.002）及心衰再住院（SHR 4.54, 1.55–13.30, p=0.006）增加相关。
PubMed · PEDIATRICS 妇产科学：Facial Dysmorphism in Infants Following Combined Prenatal Exposure to Alcohol and Tobacco.
原文摘录：OBJECTIVES: Alcohol and smoking have well-established teratogenic effects; however, despite their frequent co-use during pregnancy, the combined impact on fetal development remains less understood. … These findings highlight the importance of interventions targeting alcohol and smoking cessation during pregnancy to reduce teratogenic risk
PubMed · PLoS ONE 医学研究：Calibration of a fully closed-loop lumped-parameter cardiovascular model with baroreflex in response to induced central hypovolemia.
原文摘录：Calibration of cardiovascular models is essential to their clinical utility. We provide a full description of the calibration of a non-linear, dynamic model using global optimisation methods. … 61% after the fitting, respectively
PubMed · The Lancet Infectious Diseases Ganaplacide联合lumefantrine固体分散体治疗儿童非复杂性恶性疟的KALUMI开放标签多中心随机对照II期非劣效试验
一项在布基纳法索、马里、科特迪瓦、加蓬和刚果（金）十家机构开展的开放标签、多中心、随机、适应性、II期非劣效试验（NCT04546633，已完成），评估ganaplacide 400 mg联合lumefantrine固体分散体治疗非复杂性恶性疟儿童（6个月至<18岁）的食物效应与非劣效性，对照artemether-lumefantrine。
PubMed · American Journal of Physiology-Endocrinology and Metabolism 线粒体氧甾醇信号在表观遗传调控与治疗研发中的综述：larsucosterol 2b期主要终点未达
作者综述线粒体胆固醇代谢与氧甾醇硫酸化如何经DNMT1、DNMT3A/3B活性影响DNA甲基化及肝细胞-巨噬细胞通讯，提出氧甾醇表观遗传“微调器”模型。
PubMed · JNCI Journal of the National Cancer Institute 肿瘤学：The risk of gastric mucosa-associated lymphoid tissue (MALT) lymphoma after Helicobacter pylori eradication treatment.
原文摘录：BACKGROUND: Helicobacter pylori eradication leads to complete tumor regression in most gastric mucosa-associated lymphoid tissue (MALT) lymphomas. … CONCLUSION: From six years after Helicobacter pylori eradication treatment, the risk of gastric MALT lymphoma was no longer higher than that of the background population
PubMed · eLife 体外微孔限制诱导表皮角质形成细胞振荡迁移并形成三区室上皮结构，Piezo1与keratin 6为负向调节因子
日本研究团队的体外实验显示，皮肤角质形成细胞经3.0 µm微孔迁移时呈振荡式移动并经历EMT，形成膜上复层上皮、孔内EMT状态与膜下新生复层上皮的三区室结构，较大微孔则单向迁移且不能维持该结构。活细胞成像显示富肌动蛋白丝状伪足在孔中伸缩，Piezo1和keratin 6被鉴定为细胞进出微孔的负向调节因子。该非癌上皮模型或有助于重现创伤愈合的关键环节，属临床前体外研究。
PubMed · European Urology 多中心回顾系列报告下腹前入路单孔机器人腹膜后肾输尿管切除术（LAA-SP RNU）治疗上尿路尿路上皮癌的手术技术、围手术期与早期肿瘤学结果
五家转诊中心对47例上尿路尿路上皮癌患者行下腹前入路单孔机器人肾输尿管切除术（LAA-SP RNU）的回顾性系列（2024年5月至2025年7月）显示，经单个4 cm腹膜外切口完成切除、膀胱袖状切除及选择性淋巴结清扫。
PubMed · Surgical Endoscopy 术前EUS应变弹性成像预测胰十二指切除术中胰腺质地的前瞻性诊断准确性研究
一项单中心前瞻性研究纳入100例择期胰十二指肠切除术患者，评估术前EUS应变率（预设阈值≤2.5）预测术中胰腺质地的准确性：敏感度87.9%（95% CI 77.1-94.0），特异度83.3%（69.4-91.7），准确率86.0%，AUC 0.91（0.84-0.96）。
The Lancet · Online 精神医学：[Seminar] Eating disorders
原文摘录：The eating and feeding disorders are serious psychiatric disorders at the mind–body interface, often with an exceptionally high burden for affected individuals, their families and supporters, and wider society.
Nature · 主刊混合内容 心血管医学：In Vivo CRISPR Base Editing of ANGPTL3 for Durable Lipid Lowering
原文摘录：Download PDF Abstract Circulating concentrations of low-density lipoprotein cholesterol (LDL-C) and triglyceride-rich lipoproteins are leading risk factors for atherosclerotic cardiovascular disease 1 . … 1038/s41586-026-11233-9
Nature · 主刊混合内容 医学研究：Preprint platform offers to pay researchers to review papers, but questions remain
原文摘录：Email Bluesky Facebook LinkedIn Reddit Whatsapp X View saved research Paying researchers to review papers is seen as a potential solution to clearing the peer-reviewing backlog. … Shanghai, Beijing, Nanjing, New Delhi or Pune – hybrid working model Springer Nature Ltd Assistant Professor Positions at City University of Hong Kong (Dongguan) The University invites individuals from diverse backgrounds to apply for faculty positions in this field Dongguan, Guangdong, China City University of Hong Kong (Dongguan) Professor / Associate Professor Positions at City University of Hong Kong (Dongguan) The University invites individuals from diverse backgrounds to apply for faculty positions in this field Dongguan, Guangdong, China City University of Hong Kong (Dongguan) Chair Professor Positions at City University of Hong Kong (Dongguan) The University invites individuals from diverse backgrounds to apply for faculty positions in this field Dongguan, Guangdong, China City University of Hong Kong (Dongguan)
Nature · 主刊混合内容 急诊与重症医学：Cholera bacterium’s good deed: inspiring a glue with rare properties
原文摘录：Email Bluesky Facebook LinkedIn Reddit Whatsapp X View saved research The bacterium Vibrio cholerae causes disease in humans, but is also good at securing itself to surfaces in the form of a biofilm.
PubMed · Phytopathology 长读长全基因组测序解析北美玉米内布拉斯加棒状杆菌（Clavibacter nebraskensis）群体基因组与功能多样性
研究用长读长全基因组测序与表型分析鉴定玉米Goss's萎蔫病病原Clavibacter nebraskensis的群体多样性，生成24个基因组，含20个墨西哥当代分离株和4个1969—1996年美国历史菌株，并与北美、南非公开基因组比较。
PubMed · Nature Genetics TCRi：从单细胞 RNA 与 TCR 测序推断 T 细胞动态的信息论框架
Nicholas Ceglia 等在 Nature Genetics 发表 TCRi，一个层级贝叶斯信息论框架，从配对的单细胞转录组与 TCR 测序数据推断克隆型与表型的联合概率分布，并计算克隆型熵、表型熵、表型通量和互信息。
PubMed · American Journal of Epidemiology 儿科学：Assessing mediation of sexual orientation disparities in miscarriage by age at pregnancy, gravidity, and use of medically assisted reproduction in four national cohorts.
原文摘录：Recent research has documented a higher miscarriage risk among sexual minority individuals than heterosexual individuals. These disparities may be partly mediated by age at pregnancy, gravidity, and use of medically assisted reproduction (MAR). … structural factors in sexual orientation disparities in miscarriage
PubMed · Journal of Bacteriology 感染病学：msDNA: the story of a unique satellite DNA molecule in bacteria.
原文摘录：msDNA, or multi-copy single-stranded DNA, is a small satellite DNA observed in DNA extracts from a bacterial cell. A genetic element, usually found on the chromosome, called a retron, is responsible for producing msDNA.
PubMed · Transplantation 消化与肝病：The Impact of the Modified Kidney Donor Profile Index on the Nonuse of Kidneys From Donors With Hepatitis C.
原文摘录：BACKGROUND: Donor hepatitis C virus (HCV) status was removed from the Kidney Donor Profile Index (KDPI) in October 2024 to better align the score with contemporary outcomes. … CONCLUSIONS: Removal of HCV from the KDPI equation has improved utilization of NAT - /Ab + kidneys, whereas NAT + kidneys continued to experience excess nonuse despite rising candidate willingness to accept HCV-exposed kidneys
PubMed · Nature Protocols Nature Protocols发表Persephone流程：人全身体代谢模型（WBM）与群体微生物组模型的个性化与分析方法
发表于Nature Protocols的Persephone是用于人全身体代谢模型（WBM）个性化与评估的计算流程，属方法方案，可从原始测序数据构建群体微生物组模型、利用生理与代谢组数据生成个性化WBM并将其合并，还可按用户定义反应优化模型并进行统计与可视化。基于100个宏基因组样本，在单台计算机上运行需数天至一周，未涉及临床结局验证。
PubMed · Critical Care Medicine 急诊与重症医学：Shortening the Family Satisfaction in the ICU (FS-ICU): Development and Validation of a 12-Item Family Satisfaction Survey for Adult ICUs.
原文摘录：OBJECTIVES: To develop and validate a shorter Family Satisfaction in the ICU (FS-ICU) questionnaire that reduces survey length while preserving content and psychometric performance for quality improvement and benchmarking.
PubMed · Blood 临床试验：CD20-directed Autologous CAR T-cell Therapy for Waldenström Macroglobulinemia.
原文摘录：No chimeric antigen receptor therapy (CAR-T) is currently approved for WM. This study assessed safety and efficacy of CD20-targeted CAR-T in BTKi-refractory, heavily pre-treated WM patients.
PubMed · Current Biology 斑马鱼研究显示中枢神经系统5-羟色胺信号对脊柱形态发生必不可少
斑马鱼动物模型研究显示，tph2突变导致5-羟色胺（5HT）缺失，幼鱼在受精后21天出现进行性三维脊柱侧弯，矢状面与冠状面畸形随年龄加重且无椎体结构异常，类似青少年特发性脊柱侧凸（AIS）。脊髓内5羟色胺能神经元逐渐耗竭，加上下中脑核脊髓上投射消失，使21 dpf时脊髓5HT来源完全丧失，而Reissner纤维完整。结果提示脊髓5HT信号在胚胎后发育期的脊柱对齐中起关键作用。
PubMed · Pediatric Research 青少年遗传预测身高达成情况：一项全国性人群队列研究
一项基于大型健康维护组织数据库的回顾性全国人群队列研究评估2007年出生、12岁起持续参保且有父母身高数据的青少年是否达成mid-parental height（MPH），约18岁时测量成年身高。
PubMed · Intensive Care Medicine 急性脑损伤重症患者通气试验核心结局集国际Delphi共识研究发表
研究人员针对急性脑损伤（ABI）重症患者机械通气撤离试验结局异质性问题，按COS-STAD/COS-STAD标准开展4轮国际Delphi研究，来自31个国家的多学科小组参与评分。
PubMed · Gynecologic Oncology 表达hIFNβ与NIS的静脉注射水疱性口炎病毒VSV-hIFNβ-NIS治疗IV期或复发性子宫内膜癌的I期试验发表
Gynecologic Oncology发表一项I期、3+3剂量递增试验，21例IV期或复发性子宫内膜癌患者接受单次静脉输注VSV-hIFNβ-NIS（2017-09-15至2023-01-10），主要终点为最大耐受剂量（MTD），因药物生产限制未升至DL5，MTD未达到。
PubMed · Journal of Clinical Investigation 研究提示细胞衰老是面肩肱型肌营养不良症（FSHD）的关键病理机制，拉米夫定在小鼠模型中改善相关病变
研究团队在患者肌肉转录组与FSHD小鼠模型中识别细胞衰老及衰老相关分泌表型（SASP）为早期核心机制，相关信号在MRI未见炎症的肌肉中已可检测，成纤维脂肪祖细胞和巨噬细胞为主要衰老细胞群。在FSHD小鼠模型中，逆转录酶抑制剂拉米夫定（lamivudine, 3TC）显著减少衰老、炎症和纤维化并促进肌肉再生，作者提出衰老干预策略值得临床研究。该治疗证据来自动物模型阶段，尚未经临床验证。
PubMed · Journal of Dental Research 综述：牙周炎宿主调节疗法的性别特异性证据分析
这是一篇发表于 Journal of Dental Research 的综述，梳理临床前与临床证据，探讨生物学性别通过激素信号与性染色体相关机制影响牙周炎宿主免疫反应及骨吸收。
PubMed · The Annals of Thoracic Surgery 胸外科医师学会（STS）发布2026年肺癌切除术长期风险模型
STS 基于2015–2023年通用胸外科数据库中112,756例根治性肺切除的原发性肺癌成人患者，开发并验证术后长期生存风险模型，死亡为主要终点，随访截断于7年。
PubMed · Nature Communications 精神医学：Single-cell atlas uncovers layer 4 heterogeneity and functional gradients in rhesus macaque visual cortex.
原文摘录：Non-human primates like rhesus macaques are pivotal models for decoding human visual cortex physiology and disorders. However, there is a lack of high-resolution transcriptomic atlases comparing distinct areas of the visual cortex in macaque.
PubMed · Biomedicine & Pharmacotherapy 精神医学：Propranolol disrupts fear-induced persistent cocaine place preference and unmasks an aversion component.
原文摘录：Post-traumatic stress disorder (PTSD) and cocaine use disorder frequently co-occur, but how traumatic memories influence drug-associated behavior during drug withdrawal is unclear. … Our findings identify fear memory reactivations as an active regulator of drug-associated motivational states during withdrawal, with a noradrenergic mechanism as a proximal mediator, suggesting that β-adrenergic blockade combined with exposure-based extinction may benefit comorbid PTSD and cocaine use disorder
PubMed · Nature Cell Biology Nature Cell Biology发表机制研究：特定位点复制叉不稳定驱动PARP抑制剂细胞毒性
研究团队通过CRISPR筛选发现，复制耦联的cohesin乙酰转移酶ESCO2缺失使肿瘤细胞对PARP抑制剂（PARPi）超敏，且不依赖同源重组缺陷。
PubMed · World Journal of Surgery 胃电刺激预防腹部大手术后肠麻痹（STIMULATE）：单中心随机盲法可行性研究
丹麦奥胡斯大学医院开展单中心随机盲法可行性研究，评估腹膜细胞减灭术联合腹腔热灌注化疗患者术中胃部直接电刺激预防术后肠麻痹（POI）的安全性与可行性。20例随机分组，19例纳入分析，干预组完成率8/10、对照组9/10，治疗耐受良好，最常见不良事件为腹肌痉挛；结果支持开展进一步临床研究。试验注册号NCT05752071。
PubMed · JNCI Journal of the National Cancer Institute精选 肿瘤学：Treatment-related neutropenia as predictor of response to adjuvant palbociclib in the PALLAS trial (ABCSG-42/AFT-05/BIG-14-13/PrE0109).
原文摘录：BACKGROUND: Prior analyses of PALLAS (NCT02513394), a phase III trial that randomized patients with stage II-III hormone receptor-positive breast cancer to receive adjuvant palbociclib plus endocrine therapy (ET) or ET alone, did not show benefit of the c … gov, NCT02513394
关注理由：这条肿瘤学内容涉及随机对照研究，建议同时核对纳入人群、主要终点与报告结果。
PubMed · Journal of Applied Microbiology 感染病学：A microfluidic model of bacterial keratitis to quantify the efficacy of anti-infective compounds under flow.
原文摘录：AIMS: Bacterial infections of the cornea, also known as bacterial keratitis, are a major cause of blindness. The corneal surface is protected against infection by the flow of tear fluid, which displaces potential pathogens and debris. … These findings, obtained using two widely studied model strains, illustrate how microfluidic models of infection can offer valuable insights into how flow influences bacterial keratitis and guide the development of new treatments
PubMed · British Journal Of Nutrition 本地食物数据库联合照片辅助24小时膳食回顾提高哥伦比亚成年人膳食评估准确性：与USDA ASA24比较的横断面研究
一项在20名哥伦比亚成年人中开展的横断面研究显示，使用富含本地食物的定制数据库（DbF）结合照片辅助24小时回顾，较USDA ASA24（FNDDS 2017-2018）以称重记录为参照的准确性更高：能量和宏量营养素相关系数ρ>0·90。