吸食大麻的急性药代动力学与药效学效应因性别和使用频率而异：一项随机对照试验
一项随机、双盲、安慰剂对照交叉研究纳入44名参与者（22名女性），分别吸食0%、4%（约20 mg THC）和10%（约60 mg THC）三种强度大麻。
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PubMed · Neuropsychopharmacology PubMed · Journal of Consulting and Clinical Psychology 研究对比大语言模型与人类治疗师在抑郁症心理动力学心理治疗干预生成中的表现
一项发表于 Journal of Consulting and Clinical Psychology 的研究在抑郁症16次支持-表达式心理动力学心理治疗场景下，构建由四个专门LLM智能体和一个Judge-LLM组成的框架，用300个含人类与LLM响应的治疗片段评估。
EMA · Withdrawn Applications精选 肿瘤学：Withdrawn application: Ibrance, 15/10/2026
原文摘录：Ibrance - withdrawal of application for variation to marketing authorisation Application withdrawn The application for a change to this medicine's authorisation has been withdrawn palbociclib Post-authorisation Human Overview Pfizer Europe MA EEIG withdre … News on Ibrance Meeting highlights from the Committee for Medicinal Products for Human Use (CHMP) 12-15 October 2026 16/10/2026 Meeting highlights from the Committee for Medicinal Products for Human Use (CHMP) 12-15 September 2016 (corrected) 21/09/2016 New treatment for breast cancer 16/09/2016 More information on Ibrance Ibrance This page was last updated on 28/10/2026
关注理由：这篇肿瘤学内容涉及临床试验，适合了解研究正在回答什么问题，试验阶段和主要终点需以原文为准。
Derek Lowe · In the Pipeline 操纵Warburg效应：线粒体表达假单胞菌D-丙氨酸脱氢酶生成丙酮酸，减缓体外肿瘤细胞增殖
研究者在细胞线粒体基质表达来自假单胞菌的D-丙氨酸脱氢酶，加入D-丙氨酸使肿瘤细胞线粒体内直接生成丙酮酸（Grubaw系统），恢复氧化代谢。该体外操作使患者来源黑色素瘤细胞等增殖减慢、DNA复制与增殖相关基因受抑；HeLa细胞反将线粒体内多余丙酮酸排出胞外，转运通路未知。研究证实肿瘤细胞得益于Warburg效应下的糖酵解转换，线粒体活动本身即可下调肿瘤细胞增殖。
PubMed · Environment International 玉米赤霉烯酮作为分子胶促进PPARγ的K33链接泛素化降解，花色苷C3G可缓解其对小鼠葡萄糖代谢的影响（机制研究）
环境国际（Environment International）发表的机制研究显示，真菌毒素玉米赤霉烯酮（ZEA）作为分子胶促进PPARγ发生K33链接多聚泛素化并经蛋白酶体降解，抑制其转录活性与下游糖酵解基因表达。
PubMed · Neuroreport 神经内科：Lycopene protects against early brain injury after subarachnoid hemorrhage via suppressing endoplasmic reticulum stress.
原文摘录：OBJECTIVES: Neuroinflammation is closely associated with the poor prognosis of patients with subarachnoid hemorrhage (SAH). Lycopene (Lyc), a naturally occurring carotenoid, possesses multiple pharmacological effects, especially its neuroprotective functi
PubMed · Endocrine Reviews 肿瘤学：Overlapping roles of dysregulated glycolysis in the pathophysiology of diabetes and cancer.
原文摘录：Emerging evidence highlights a strong association between type 2 diabetes (T2D) and increased cancer risk, with partially overlapping metabolic disruptions potentially driving both diseases.
PubMed · Pharmaceutical Research 基于建模与模拟预测弱碱性药物口服吸收：胃酸抑制药与储存致游离型药物增加的影响
研究者建立了一个模拟模型，结合体外溶解度、渗透性与沉淀实验数据，预测胃pH及片剂储存中游离型药物增加对弱碱性药物口服吸收的影响。模型以健康志愿者胶囊临床数据验证，预测误差在±19%以内，并成功再现了合用胃酸抑制药（ARAs）受试者血浆浓度下降，观测与预测的血浆浓度比值分别为0.14和0.25。该模型可辅助制剂设计与临床开发，尚属模拟方法学研究。
PubMed · Chemical Reviews 外科与麻醉：Mapping Local Environments in Single-Atom Catalysts.
原文摘录：Single-atom catalysts (SACs) offer exceptional structural resolution for investigating how local environments govern catalytic behavior and, ultimately, for controlling these effects through catalyst design. … By integrating aspects that are often considered separately and highlighting those that remain insufficiently addressed, we provide a roadmap toward the predictive, environment-driven design of SACs and a deeper understanding of catalytic phenomena
PubMed · Human Molecular Genetics 神经肌肉疾病基因的基因组特征分析：639个基因在表达、约束与进化保守性上区别于其他编码基因
一项生物信息学研究用Boruta机器学习特征选择，结合统计比较，分析639个神经肌肉疾病（NMD）基因（源自GeneTable of NMDs）与134个常染色体蛋白编码基因基因组特征的差异。
PubMed · International Journal of Food Microbiology 地芽孢杆菌噬菌体来源溶菌素LysGPK联合EDTA降低新鲜生菜上大肠杆菌O157:H7的体外与分子机制研究
研究者对来源于Geobacillus噬菌体的内溶素LysGPK进行了重组表达和表征，其对革兰阴性病原体具广谱裂解活性，最适裂解条件为37°C、pH 9.0，并在70°C下保持稳定。
PubMed · Chemical Reviews 感染病学：Bacterial Surfaces and Barriers: Biogenesis and Pathogen-Host Interactions.
原文摘录：The bacterial surface represents the primary interface between pathogens and hosts, yet its chemical and architectural complexity challenges conventional classification.
PubMed · Fertility and Sterility 单中心回顾性队列：无排卵受孕周期改变孕早期子宫动脉搏动指数与子痫前期风险的关联
比利时布鲁塞尔大学医院对2021年5月至2023年12月3,651例单胎妊娠在孕11至14+1周行子宫动脉多普勒评估的单中心回顾性队列研究显示，搏动指数与子痫前期风险的关联因受孕方式而异：自然受孕妊娠中较高搏动指数与子痫前期相关（OR 5.31。
中国疾控中心 · 流感监测周报精选 2026年第43周第932期中国流感监测周报2026-10-28
中国流感流行情况概要（截至2026年 10 月 25 日） ·监测数据显示，本周南方省份流感病毒检测阳性率略有下降、北方省份流感病毒检测阳性率略有上升，全国检出流感阳性样本中甲型流感病毒占比67.6%、乙型流感病毒占比32.4%；甲型流感病毒中A(H1N1)pdm09占比32.8%、A(H3N2)占比67.2%，乙型流感病毒均为B（Victoria）系。全国共报告145起流感样病例暴发疫情。
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Derek Lowe · In the Pipeline CHAMP技术体外比较脂质化修饰对大肠杆菌与HeLa细胞穿透的影响：脂质化难以促进革兰阴性菌内摄取
一项细胞水平研究用基于HaloTag的CHAMP荧光竞争技术评估脂质化修饰对化合物进入胞质的影响，在光滑型大肠杆菌和HeLa细胞中测试多种脂质基团。细菌中所有脂质偶联物的胞内蓄积均低于未修饰母药，仅C3–C4短链有一定效果，更长脂质链显著减少进入量；HeLa细胞中C6–C8饱和直链、环状、支链和全氟链效果较佳。
medRxiv · 独立预印本 儿科学：Familial factors inflate the estimated effects of genetic liability to ADHD on behavioural outcomes
原文摘录：BackgroundPeople with ADHD have worse health, behavioural and social outcomes, widely interpreted as evidence that ADHD causes these harms, justifying early identification and treatment. … Interventions targeting the individual might not reduce these outcomes as much a
PubMed · Journal of Periodontology 美国NHANES 2011-2014分析5891名30岁以上成人颊侧牙龈退缩相关因素：按牙周炎分层
基于2011-2014年美国国家健康与营养调查（NHANES）5891名30岁以上恒牙成人的加权分析显示，颊侧牙龈退缩（GR）≥1 mm、≥3 mm和≥5 mm的加权患病率分别为91.1%、37.2%和6.0%。
medRxiv · 独立预印本 内分泌与代谢：Gene-gene and Gene-Environment Interactions Improve Genetic Risk Predictions for Complex Diseases
原文摘录：Polygenic risk scores (PRS) assume additive SNP effects, yet genetic risk also arises from interactions between loci and environmental factors that contribute to broad-sense heritability. … A composite score was predictive over traditional additive PRS and predictive of T2D among individuals whose clinical symptoms fall within normal ranges
medRxiv · 独立预印本精选 骨科与运动医学：Statistical Analysis Plan for the REDEP study: Effectiveness of dual-mobility cups for preventing dislocation after primary total hip arthroplasty by a posterolateral approach compared to unipolar cups in elderly patients
原文摘录：Periprosthetic hip dislocation is a frequent complication after primary total hip arthroplasty. Observational studies suggest that dual mobility cups may reduce dislocation risk to approximately 1%, but definitive randomized evidence supporting their rout
关注理由：如果关注骨科与运动医学，这项随机对照研究的分组方式、主要终点和组间差异值得细读。
medRxiv · 独立预印本精选 神经内科：Clinical Significance and Distribution of Cerebrospinal Fluid Type IV Oligoclonal Band Pattern in Neurological Disorders: A Retrospective Analysis
原文摘录：Background and ObjectivesTo characterize the clinical features and cerebrospinal fluid (CSF) findings of patients exhibiting a type IV oligoclonal band (OCB) pattern, defined by the presence of identical IgG bands in both CSF and serum. … These findings support cautious interpretation of the type IV pattern in routine clinical practice
关注理由：这条神经内科内容值得查看其研究问题与证据来源，具体结论和适用范围以原文为准。
PubMed · International Journal of Obesity 系统综述：儿童期虐待与体成分指标的关联（International Journal of Obesity）
一项发表于 International Journal of Obesity 的系统综述检索 MEDLINE、Embase、LILACS、Scopus、PsycINFO 和 Web of Science 至2026年4月23日的文献，纳入12项研究（2015–2026年，样本75–151,143人，3–90岁），其中9项为横断面或横断面分析、3项为纵向设计。
PubMed · NeuroImage 神经内科：Spectral-spatial modeling of neural couplings in functional connectivity of motor networks.
原文摘录：BACKGROUND: Functional neural connectivity reflects coordinated interactions within brain networks in both health and disease.
medRxiv · 独立预印本 骨科与运动医学：Implementation of high-dose glucocorticoids and opioid consumption in the first 24 hours after elective hip and knee arthroplasty: a natural experiment study of 47,317 procedures in Eastern Denmark
原文摘录：BackgroundIn Denmark, high-dose perioperative glucocorticoids were implemented stepwise for patients undergoing total hip arthroplasty (THA), total knee arthroplasty (TKA), and unicompartmental knee arthroplasty (UKA). … ConclusionsImplementation of high-dose glucocorticoids was associated with only a small drop in opioid consumption, below the minimal important differenc
medRxiv · 独立预印本精选 外科与麻醉：Educational expectations and needs of individuals scheduled for breast surgery within the Primary Nursing Model: a qualitative study
原文摘录：BackgroundA diagnosis of breast cancer may represent a potentially destabilizing event, with significant physical, psychological, and social implications. … The transcripts will be analyzed using thematic analysis according to Braun and Clarke, with a ph
关注理由：这条外科与麻醉内容涉及相关临床或研究问题，建议查看原文中的方法与适用范围。
medRxiv · 独立预印本 呼吸病学：A Unified Flexible Large Polysomnography Model for Sleep Staging and Downstream Clinical Screening
原文摘录：Polysomnography (PSG) is central to sleep medicine, yet its analysis remains hindered by labor-intensive manual scoring and limited cross-center generalizability.
medRxiv · 独立预印本 行业资料：CREBBP variants underlying Menke-Hennekam syndrome exhibit histone acetyltransferase hyperactivity with divergent phase behaviors
原文摘录：Menke-Hennekam syndrome (MKHK) is a neurodevelopmental disease characterized by specific pathogenic regions within the transcriptional coactivator CREB-binding protein (CREBBP).
PubMed · The Journal of Nervous and Mental Disease 认知矫正治疗精神分裂症与抑郁症：治疗参与和作业完成预测因素的两项研究分析
两项研究共纳入精神分裂症患者70例和抑郁症患者74例，以治疗出席率和作业完成率（低于50%定义为非参与）评估认知矫正治疗（CR）的参与情况。精神分裂症患者中，治疗参与者年龄更大、出院时间更长、接受以执行功能训练为主的CR，作业参与者神经认知功能更高，且仅CR类型（执行功能训练）预测出席率；抑郁症患者中治疗和作业参与组间均未见显著差异。
PubMed · NeuroImage 儿科学：Distinct neural patterns of valence and arousal in the developing brain: A representational similarity analysis of MEG.
原文摘录：How children and adolescents encode the affective meaning of visual stimuli remains poorly understood. A key reason is that valence and arousal are inherently correlated across affective stimuli and thus confounded in the categorical contrasts mostly used
PubMed · Journal of Lipid Research 2-羟基油酸在实验性结肠炎模型中维持脂质稳态与上皮屏障功能（临床前研究）
临床前研究显示，合成油酸衍生物2-羟基油酸（2-OHOA）在IFN-γ/TNF-α刺激的Caco-2单层和DSS诱导小鼠结肠炎模型中可减轻屏障功能障碍、炎症指标和组织损伤，同浓度/剂量油酸（OA）作用微弱。
PubMed · Cancer Letters 临床前研究：MUC16 驱动胰腺癌中巨噬细胞介导的免疫抑制
研究者用 KPC 及 KPC-MUC16 敲除基因工程与原位小鼠模型发现，MUC16 缺失显著降低肿瘤负荷，减少 CD206+ 和 Ym1/2+ M2 样巨噬细胞、提高 M1/M2 比值并改善生存。
PubMed · Neuropharmacology 小白菊内酯通过激活GSK3β-抑制CREB信号下调transgelin-2抑制胶质母细胞瘤恶性进展的机制研究
一项体外与动物研究显示，从药用植物小白菊提取的倍半萜内酯parthenolide（Pt）可诱导人U-87MG和T98G胶质母细胞瘤细胞凋亡、抑制干性和侵袭，并在雄性NOD-SCID小鼠原位GBM模型中增强替莫唑胺（TMZ）疗效。
PubMed · The Journal of Experimental Medicine 《实验医学杂志》研究：结直肠癌类器官原位移植模型显示不同转移潜能肿瘤诱导早期T细胞应答分化
结直肠癌多数对免疫治疗耐药。
PubMed · Virology 神经内科：Neurotropic herpesviruses as accelerators of brain aging: The role of latency and reactivation in neurodegeneration.
原文摘录：Neurotropic herpesviruses establish lifelong latency within the human nervous system. Traditionally viewed as either harmless latent infections or rare causes of acute encephalitis, growing evidence suggests these viruses undergo recurrent, subclinical re
PubMed · Frontiers in Immunology 食管鳞癌回顾性队列：EDRIC相关免疫损伤中介约三分之一ENI照射策略的生存劣势
一项纳入279例接受根治性同步放化疗食管鳞癌患者的回顾性队列研究（2011–2015）显示，ENI较IFI显著升高EDRIC（8.17 vs 7.42 Gy；P=0.01），高EDRIC（>7.8 Gy）独立预示更差OS（HR=1.746；P<0.001）。
PubMed · Oncogene Oncogene 发表观点文章：肿瘤微环境的记忆、表观遗传疤痕与治疗复发的滞后逻辑
Kokkanti 等在 Oncogene 发表观点性论述，提出肿瘤微环境（TME）记忆概念，认为慢性炎症、代谢应激、治疗压力和细胞外基质重塑可在癌细胞与基质细胞中留下持久表观遗传与结构印迹，形成依赖历史的表型。
PubMed · International Journal of Obesity 英国多族裔出生队列研究：孕中期代谢组学与0–36个月婴幼儿生长轨迹的关联分析
英国Born in Bradford多族裔出生队列的纵向研究纳入1423对母婴，用NMR定量孕26–28周空腹血中147种代谢物，以潜在类别增长混合模型刻画0–36个月体重、身长/身高和BMI的 normative、intermediate、non-uniform 三类轨迹。
北京脑科学与类脑研究所 · 科研动态 “北脑一号”临床阶段半侵入式脑机系统助残场景入选国家首批136项重大应用场景项目清单
北京脑科学与类脑研究所与北京芯智达神经技术有限公司联合实施的“北脑一号”智能脑机科技助残重建瘫痪患者运动功能应用场景，入选国家发展改革委等部门发布的首批136项国家标志性重大应用场景项目。该系统为临床阶段半侵入式、无线全植入脑机系统，已完成44余例人体植入，最长植入超过20个月，累计人体安全工作时长超17万小时，注册临床试验患者入组全部完成。项目计划2027年申报医疗器械注册证。
WHO · Disease Outbreak News OData精选 诊断与检测：Ebola disease caused by Bundibugyo virus - Democratic Republic of the Congo, Kenya and Nigeria
原文摘录：See all DONs related to this event Read more about Ebola disease Situation at a glance Since the publication of the previous Disease Outbreak News on 8 October 2026, the Bundibugyo virus disease (BVD) outbreak has expanded geographically in the Democratic … item/2026-DON622
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Derek Lowe · In the Pipeline精选 Derek Lowe解读intismeran autogene联合Keytruda黑色素瘤术后III期中期结果：复发或死亡风险降低42%
Merck与Moderna公布intismeran autogene联合Keytruda治疗黑色素瘤术后患者的III期中期结果：中位随访两年，联合组复发或死亡风险较Keytruda单药降低42%，两年未复发率为82.2%对70%，主要终点无复发生存期达到。
关注理由：该评论将泄露后公布的III期中期数据与II期结果及Keytruda单药两年基线对照，指出总生存期尚未成熟、膀胱癌与肾细胞癌数据未读出，有助于把疗效信息与资本市场波动分开看待。
EMA · News and Safety Reviews精选 儿科学：AMA and EMA issue joint guidance on Ebola vaccine development
原文摘录：Image credit: © peterschreiber.media | stock.adobe.com AMA and EMA issue joint guidance on Ebola vaccine development 23 October 2026 Clinical trial requirements defined for rapid development of Bundibugyo virus vaccines News Human Clinical trials Research … eu All other enquiries Please submit your request via the online form
关注理由：这条儿科学资料涉及临床试验，入组条件、对照设置和研究阶段可以帮助判断结果适用于哪些人群。