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10月14日周三
10月13日周二
10月12日周一
  1. PubMed · Biomacromolecules

    血红蛋白-PEG 超分子聚合平衡研究为尺寸可控聚合物颗粒提供结构基础（Biomacromolecules 发表）

    研究者将血红蛋白（Hb）的β亚基经不同分子量（10、40 kDa）四臂PEG桥接构建双环单体，其可经浓度依赖的超分子开环聚合，从离散单体可控地形成聚合物颗粒直至凝胶网络，并用 DBBF 对 Hb 进行分子内 ββ 交联实现各聚合物物种的共价固定，固定产物保留了特征性 O2 结合性质。

  2. PubMed · American Journal of Physiology-Heart and Circulatory Physiology

    PASC患者直立与运动不耐受伴交感神经调控和心脏储备正常：一项微神经图与心脏MRI对照研究

    Erin J Howden团队在American Journal of Physiology-Heart and Circulatory Physiology发表研究，纳入35例症状超过3个月、无明显合并症的PASC成人及12名年龄性别匹配的康复对照，进行CPET、超声心动图、静息与运动心脏MRI及腓总神经微神经图MSNA记录和60°直立倾斜试验。

  3. PubMed · Archives of Biochemistry and Biophysics

    肿瘤学：The p.V27A variant of l-asparaginase II minimizes glutaminase activity without compromising anti-leukemic function.

    原文摘录：l-Asparaginase is a fundamental chemotherapeutic agent for acute lymphoblastic leukemia (ALL) that depletes circulating asparagine to induce apoptosis in leukemic blasts. … V27A variant delivers an improved safety profile without compromising therapeutic potency, emerging as

10月10日周六
  1. WHO · Disease Outbreak News OData

    感染病学：Pneumonia of undetermined etiology - the Russian Federation

    原文摘录：Disease Outbreak News Pneumonia of undetermined etiology - Russian Federation 10 October 2026 See all DONs related to this event Situation at a glance On 2 October 2026, WHO became aware through media reports of the death of an employee of the Irkutsk Ant … item/2026-DON620 See all DONs related to this event

    关注理由：这条感染病学资料适合作为深入阅读入口，尤其要关注研究方法与结论是否匹配。

  2. PubMed · Atherosclerosis

    巨噬细胞来源TNF-α经TNFRSF1A促进人动脉粥样硬化斑块血管炎症的机制研究

    研究者对人的颈动脉和冠状动脉斑块进行单细胞RNA测序与空间转录组分析，并用THP-1巨噬细胞体外实验验证，发现巨噬细胞来源的TNF-α通过TNFRSF1A连接巨噬细胞、内皮细胞与平滑肌细胞，促进血管细胞死亡、NF-κB/MAPK激活和泡沫细胞形成。该信号轴在两种血管床斑块中表现保守，作者提出其可作为动脉粥样硬化的潜在治疗靶点。研究含体外机制部分，疗效结论尚待进一步验证。

  3. PubMed · Molecular Psychiatry

    童年虐待与成人创伤后症状关联的脑白质微结构中介作用分析：基于INTRuST联盟299人弥散MRI研究发表于Molecular Psychiatry

    一项纳入INTRuST临床联盟299名参与者（56例PTSD、107例mTBI、136名对照）的弥散MRI横断面分析显示，童年虐待严重程度越高，平均扩散系数（MD）和轴向扩散系数（AD）越低，且独立于PTSD和/或mTBI状态。

10月9日周五
  1. EMA · Withdrawn Applications

    儿科学：Withdrawn application: Kalydeco, 01/09/2026

    原文摘录：Kalydeco - withdrawal of application for variation to marketing authorisation Application withdrawn The application for a change to this medicine's authorisation has been withdrawn ivacaftor Post-authorisation Human Overview Vertex Pharmaceuticals (Irelan … News on Kalydeco Meeting highlights from the Committee for Medicinal Products for Human Use (CHMP) 14-17 September 2026 18/09/2026 Combination of cystic fibrosis medicines to treat patients with rare mutations 28/02/2025 Meeting highlights from the Committee for Medicinal Products for Human Use (CHMP) 19-22 February 2024 23/02/2024 Meeting highlights from the Committee for Medicinal Products for Human Use (CHMP) 11-14 September 2023 15/09/2023 Meeting highlights from the Committee for Medicinal Products for Human Use (CHMP) 8-11 November 2021 12/11/2021 Meeting highlights from the Committee for Medicinal Products for Human Use (CHMP) 22-25 March 2021 26/03/2021 Meeting highlights from the Committee for Medicinal Products for Human Use (CHMP) 14-17 September 2020 18/09/2020 Meeting highlights from the Committee for Medicinal Products for Human Use (CHMP) 20-23 July 2020 24/07/2020 Meeting highlights from the Committee for Medicinal Products for Human Use (CHMP) 28-30 April 2020 30/04/2020 Meeting highlights from the Committee for Medicinal Products for Human Use (CHMP) 14-17 October 2019 18/10/2019 Meeting highlights from the Committee for Medicinal Products for Human Use (CHMP) 15-18 October 2018 19/10/2018 Meeting highlights from the Committee for Medicinal Products for Human Use (CHMP) 23-26 July 2018 27/07/2018 Meeting highlights from the Committee for Medicinal Products for Human Use (CHMP) 21-24 September 2015 25/09/2015 Meeting highlights from the Committee for Medicinal Products for Human Use (CHMP) 23-26 June 2014 27/06/2014 More information on Kalydeco Kalydeco This page was last updated on 09/10/2026

    关注理由：这条儿科学临床试验动态值得跟踪，后续可结合原文核对试验进度、研究设计与结果披露情况。

  3. PubMed / NCBI E-utilities

    妇产科学：Influence of perineal tears and body image disturbance on postpartum sexual quality of life: a cross-sectional study.

    原文摘录：BACKGROUND: Whether perineal injury severity independently determines postpartum sexual quality of life (SQoL) is unclear. This study evaluated perineal tears and body image as determinants of SQoL and sexual resumption timing. … OASI carries a substantial risk of delayed sexual resumption, warranting dedicated postpartum counseling

10月8日周四
  3. PubMed · Journal of Affective Disorders

    治疗抵抗性抑郁症rTMS后缓解预测：简约与集成机器学习模型对比的回顾性队列研究

    研究者在一项含263名成人、经10次重复10折交叉验证内部验证的回顾性队列中，比较重复经颅磁刺激（rTMS）治疗抵抗性抑郁症后的缓解预测模型，71人（27.0%）缓解（随访MADRS≤10）。校准后ROC-AUC范围0.685–0.711，三变量logistic回归为0.707，更丰富特征集与SuperLearner集成的配对差异均无显著（BH校正后）。作者指出这些发现不建立等效性或可迁移性。

  4. PubMed · Journal of Affective Disorders

    韩国2021年全国精神健康调查：成年自杀意念者潜在特征分析显示意念近因与终身行为史提供互补信息

    基于2021年韩国全国精神健康调查5511名成年人的数据，研究对574名有终身自杀意念者进行潜在类别分析，识别出三类特征：远期意念且行为史有限（78.0%）、有终身计划与企图但当前意念低（15.3%）、当前意念伴中等程度终身计划（6.7%）。

10月7日周三
  1. PubMed · Bioorganic & Medicinal Chemistry Letters

    炔基6-硝基喹喔啉衍生物抗结核活性的构效关系研究

    一系列喹喔啉衍生物经设计并在结核分枝杆菌H37Rv株上评估体外抗结核活性，属体外研究。多个衍生物MIC90低于10 μM，其中化合物4d和3b活性最强，MIC分别为0.97 μM和0.94 μM。构效关系分析显示6-硝基喹喔啉核心和炔键连接子对活性关键，叔醇侧链衍生物活性较好，化合物4h选择性指数较优但水溶性低，为该骨架进一步优化提供方向。

  5. PubMed · Acta Psychiatrica Scandinavica

    心血管医学：Risk-Stratified Cardiac Monitoring During Antipsychotic Treatment in Adolescents and Young Adults.

    原文摘录：INTRODUCTION: Antipsychotic-associated heart rate-corrected QT (QTc) prolongation and sudden cardiac death are uncommon in young people, but risk is concentrated in patients with identifiable clinical vulnerability and during selected drug- or exposure-re … The evidence supports structured baseline r

  9. PubMed · Neuroscience & Biobehavioral Reviews

    综述：猕猴神经科学中行为代理指标的效度问题——发育能力与情境可解释性框架及56项抑郁相关研究的mini-review

    该综述提出猕猴行为学指标作为认知、情感或临床构念代理时，须满足发育能力与情境可解释性两个前提，并提出“定义—解释—验证”三阶段评估框架。对56项猕猴抑郁相关行为代理研究的mini-review显示，仅17.9%充分报告养育史，操作定义缺失比例从2010–2019年的26.3%升至2020–2026年的58.3%，仅26.8%考虑情境解释，仅3.6%在模型分配前完成独立验证。

10月6日周二
  2. PubMed · American Journal of Physiology-Gastrointestinal and Liver Physiology

    前瞻性队列研究：腹腔镜胆囊切除术后12个月肠道菌群呈选择性改变，乳杆菌属持续减少

    一项前瞻性队列研究对20名计划行腹腔镜胆囊切除术的患者从术前基线至术后1、3、6、12个月随访，以16S rRNA基因测序分析粪便菌群，随访12个月完成。结果显示总体菌群多样性与群落结构仅轻度变化，但乳杆菌属在术后早期减少并持续保持较低水平；功能预测提示代谢通路仅有轻度改变，无参与者发生临床明显的胆囊切除术后腹泻。

10月5日周一
  2. PubMed · Behaviour Research and Therapy

    随机对照试验：简短认知行为治疗（BCBT）与当下中心治疗（PCT）中自杀意念各维度的动态变化模式差异

    一项在高危美国军人和退伍军人中比较BCBT与PCT的随机对照试验中，研究者每次治疗时评估自杀意念量表（SSI）前5项，用连续时间多变量变化模型和特征分解分析各维度变化。结果显示两治疗中各维度变化速度不一，BCBT下维度变化更快且更同步，PCT变化更慢且一致性较低。这提示总分相近时，两种治疗减低自杀意念的过程可能存在质的差异。

  3. PubMed · Food and Chemical Toxicology

    香原料体外遗传毒性检测策略综述：应对假阳性并推进非动物方法（ToxTracker、3D RSMN、CEGA/HET-MN、OASIS TIMES）

    一篇发表于 Food and Chemical Toxicology 的综述提出香原料的分 tier、机制导向全体外遗传毒性检测策略，整合 ToxTracker GFP 报告干细胞平台、3D 重建皮肤微核（RSMN）试验、鸡胚系统 CEGA 与 HET-MN，以及 OASIS TIMES 计算代谢预测，并给出决策流程图。

10月2日周五
10月1日周四
  1. PubMed · Journal of Psychosomatic Research

    消化与肝病：Personalized psychotherapy in irritable bowel syndrome: results from a pilot randomized controlled trial (PIONEER-IBS).

    原文摘录：OBJECTIVE: Irritable bowel syndrome (IBS) is characterized by recurring gastrointestinal symptoms and substantial psychosocial burden. Despite the wide range of therapeutic options, no approach is consistently superior across patients. … However, the benefit of treatment allocation based on individual symptom dynamics, the validity of personalization approaches and the efficacy of EMDR in specific IBS subgroups represent distinct but intertwined questions that require further evaluation

    关注理由：如果关注消化与肝病，这项随机对照研究的分组方式、主要终点和组间差异值得细读。

  3. PubMed · American Heart Journal

    EXPORT 试验方案发表：持续房颤患者在肺静脉隔离基础上附加非肺静脉触发灶消融的多中心随机试验原理与设计

    EXPORT 试验（NCT07197931）是一项多中心、前瞻性、优效性、单盲、盲法终点随机试验，拟纳入 430 例药物难治性持续性房颤首次消融患者，比较肺静脉隔离联合非肺静脉触发灶诱发、标测与消融与单纯肺静脉隔离。主要终点为 3 个月空白期后任何持续 ≥30 秒的房性心律失常记录，次要终点包括不使用抗心律失常药物的无复发、围术期并发症和总手术时间。本文为方案与设计，尚无结果数据。

  4. PubMed · Arteriosclerosis Thrombosis and Vascular Biology

    高代谢状态驱动人和小鼠MASLD血小板功能障碍的横断面与动物研究

    一项横断面研究纳入单纯脂肪变（n=42）、脂肪性肝炎（n=28）、代谢相关肝硬化（n=16）及无脂肪变对照（n=23），发现MASLD早期即出现血小板分泌标志物升高和代谢活性增强；晚期MASH和肝硬化阶段血小板对G蛋白偶联受体刺激无应答，但对GPVI刺激反应增强，呈分泌和促凝表型。

  5. Europe PMC · 撤稿与关系监测

    外科与麻醉：Withdrawn as duplicate: Pulmonary Blood Volumes on CT Predict Residual Pulmonary Hypertension Post-Pulmonary Endarterectomy.

    原文摘录：Pulmonary blood volumes (PBV), currently not assessed by computed tomography pulmonary angiography (CTPA), could provide additional information to routine investigations performed for chronic thromboembolic pulmonary hypertension (CTEPH). … Utilizing CTPA-derived PBV post-PEA to identify patients without residual PH can potentially reduce the need for routine postoperative right heart catheterization

9月30日周三
  2. PubMed · The Journal of Pathology

    小鼠研究：髓系MrgprD通过NF-κB介导巨噬细胞M1极化驱动DSS急性结肠炎

    小鼠研究显示，Mrgprd全身或髓系特异性敲除可减轻葡聚糖硫酸钠（DSS）诱导的急性结肠炎，表现为结肠长度保留、病理评分降低、屏障完整性改善及M1巨噬细胞比例下降，其作用强于神经元特异性敲除；机制上MrgprD经NF-κB信号促进结肠巨噬细胞促炎极化，生物信息分析支持MRGPRD-NF-κB轴与人类IBD相关。

  3. PubMed · Pharmacology Biochemistry and Behavior

    精神医学：Ayahuasca treatment reduces 50-kHz ultrasonic vocalizations and modifies mesocorticolimbic monoamine neurochemistry in rats.

    原文摘录：Rats emit 50-kHz ultrasonic vocalizations (USVs), a widely used measure of drug-induced motivational and affective effects and dopaminergic activity. … Together, these findings suggest that AYA attenuates LDX-induced positive affective responses without reducing hyperlocomotion, accompanied by changes in noradrenaline and serotonin levels in the mPFC and dopamine levels in the NAc