TRBC1免疫组化揭示早期蕈样肉芽肿的空间克隆不一致模式（回顾性单中心研究）
一项回顾性单中心研究发现，早期蕈样肉芽肿（MF）中TRBC1免疫组化显示单一型TRBC1表达局限于表皮内T细胞而真皮浸润呈多克隆型的空间克隆不一致模式，肿瘤期MF和Sézary综合征则呈全间室一致性限制。
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PubMed · The American Journal of Surgical Pathology PubMed · Journal of Thoracic and Cardiovascular Surgery 先天性心脏病儿童与成人感染性心内膜炎外科治疗结局的单中心回顾分析（2001–2024年96例）
一项回顾性研究纳入2001至2024年间96例因感染性心内膜炎（IE）接受手术的先天性心脏病患者（儿童52例、成人44例），院内死亡率为6.3%，术后5、10、20年生存率分别为90.6%、88.1%和80.5%，20年无复发IE率为96.4%。
PubMed · Psychological Medicine 缓解期抑郁症沉思后正念状态下左下顶叶枢纽配置异常的fMRI研究
一项发表于Psychological Medicine的fMRI研究纳入51例缓解期抑郁症（RD）患者和41名健康对照，采用六状态范式（静息、负性自传体回忆、沉思、正念、分心、静息II）结合网络统计与图论分析。
PubMed · JNCI Journal of the National Cancer Institute 肿瘤学：The ethical dilemma of excluding patients from clinical trials based on language preference.
原文摘录：Patients who prefer a language other than English (LOE) are underrepresented in clinical research trials. The reasons for lower enrollment are multi-faceted, and the literature lacks a good understanding of these causes or how to address them.
PubMed · Bioinformatics 肿瘤学：DeSCENT: Deconvolutional Single-Cell RNA-seq Enhances Transcriptome-based Cancer Survival Analysis.
原文摘录：MOTIVATION: Single-cell RNA-seq captures tumor heterogeneity, but it is rarely available together with patient survival outcomes. Bulk RNA-seq cohorts provide survival data but lack direct measurements of cellular expression.
PubMed · Infection and Immunity 感染病学：Recombinant outer-membrane vesicles (OMVs) from Salmonella Enteritidis as multivalent candidate vaccines for enteric fevers and invasive non-typhoidal Salmonella infections.
原文摘录：Invasive non-typhoidal Salmonella (iNTS) infections, typhoid, and paratyphoid fever are major global health burdens, particularly considering increasing antimicrobial resistance.
PubMed · Journal of Cell Science 基于ddFP的活细胞成像报告系统用于检测晚内体/溶酶体、内质网、线粒体及质膜间的细胞器膜接触位点
研究者开发了一系列基于二聚化依赖荧光蛋白（ddFP）的报告系统，用于在活细胞中可视化、定量并追踪细胞器间膜接触位点（MCS）。其中ddFP LELYS-ER单质粒系统靶向晚内体/溶酶体与内质网接触，可生成稳定报告细胞系，在VAP蛋白家族下调或溶酶体损伤时检测到接触数量变化，且不干扰内源性接触，活细胞成像显示这些接触具有不同的形态、移动性和寿命；同设计还扩展至ER-质膜和ER-线粒体接触。
PubMed · CHEST Journal 临床试验：Efficacy and Safety of Ulinastatin in the Treatment of Patients with Sepsis: The ADJUST Trial.
原文摘录：BACKGROUND: Urinary trypsin inhibitor (ulinastatin, UTI) has shown potential survival benefits in sepsis; however, conclusive clinical evidence is lacking. … NCT02647554
WHO · Official News OData 行业资料：FoodMed 2026 highlights the role of food, traditional knowledge and science in advancing health
原文摘录：Dr Geetha Krishnan Gopalakrishna Pillai of WHO Global Centre for Traditional Medicine, delivering his keynote at FoodMed 2026 Conference The FoodMed Conference returned for its second edition on 5–6 November 2026, bringing together international experts,
PubMed · Development Blender 组织地图投影工具（btc）发表：面向3D显微镜数据的交互式组织制图分析插件
研究人员发布开源工具 blender tissue cartography（btc），是3D编辑器Blender的交互式插件，可将体积显微镜图像中的弯曲组织表面（如上皮片）投影为2D图像以进行可视化与定量分析，配套Python库支持2D投影中的3D测量与自定义流程，时间序列数据可批量对齐处理。
PubMed · PLANT PHYSIOLOGY 行业资料：Allelic Homogenization of Detoxification Genes RsCYP3A24 and RsGSTF5 Is Associated with Metabolic Resistance to SYP-14288 in Rhizoctonia solani.
原文摘录：Fungicide resistance in multinucleate fungi, such as Rhizoctonia solani, poses a growing challenge for effective disease management. This study explores the molecular mechanisms underlying resistance to the fungicide SYP-14288 in R.
PubMed · Environmental Toxicology and Chemistry 伊维菌素对鲤鱼（Cyprinus carpio）的生物安全性与HSP70基因表达影响的动物实验研究
一项动物实验研究评估了伊维菌素（IVM）在鲤鱼中的生物安全性，测得口服LD50为8.91±3.46 mg/kg体重。单次灌服0–5.11 mg/kg共6组观察21天，RBC、WBC、Hb、PCV、肝酶、NBT活性、血清溶菌酶和HSP70表达呈剂量依赖性应激变化，≥2.55 mg/kg应激明显，0.54 mg/kg与对照组相当，定为NOAEL，1.00 mg/kg为LOAEL。
PubMed · The Journal of Clinical Endocrinology & Metabolism 医学研究：Serum Vitamin D Status and Bone Accrual Trajectories in Adolescent Idiopathic Scoliosis: A 6-Year Prospective Cohort Study.
原文摘录：BACKGROUND: In adolescent idiopathic scoliosis (AIS), low bone mineral density (BMD) and impaired bone qualities have been demonstrated to be an important risk factor for curve progression.
PubMed · American Journal of Physiology-Endocrinology and Metabolism 去脂体重水化常数0.732的机制基础研究：Wang 2008机制模型分析876名健康成人的年龄与性别差异
一项发表于American Journal of Physiology-Endocrinology and Metabolism的机制研究应用Wang 2008去脂体重水化模型，分析876名健康成人（407男、469女）测得的TBW、TBK、体密度和骨矿物质，探讨0.732水化常数的变异基础。
PubMed · Clinical Cancer Research 肿瘤学：Integrated multi-omics reveals longitudinal metabolic dynamics and reprogramming in bladder cancer.
原文摘录：PURPOSE: Bladder cancer (BCa), particularly NMIBC, poses a substantial clinical burden due to its high recurrence rates and the need for lifelong surveillance.
PubMed · Journal of Nutrition 临床试验：Lifestyle counseling including the DASH diet improves multiple metabolomic profiles.
原文摘录：BACKGROUND: Lifestyle interventions improve cardiometabolic risk factors, but data from randomized trials on their impact on detailed metabolomic profiles remain limited. … gov)
PubMed · American Journal of Respiratory and Critical Care Medicine 开发并外部验证预测COPD发生的pre-COPD评分
研究者在Copenhagen General Population Study（N=14,506）开发pre-COPD评分（含吸烟≥10包年、现吸烟、呼吸道症状、哮喘、pre-BD FEV1/FVC 0.70–0.75各1分。
PubMed · Journal of Clinical Microbiology 妇产科学：Evaluation of a new assay for the detection of IgM in recent and congenital Toxoplasma infections.
原文摘录：UNLABELLED: Toxoplasma gondii infection is usually asymptomatic in immunocompetent individuals. However, primary infection during pregnancy can lead to severe fetal manifestations. … In addition, agreements with the Architect To
PubMed · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology PTSD年轻成人中睡眠效率不规律与早期心血管功能障碍相关：28例试纸计研究提示氧化应激升高与压力反射敏感性降低
一项包含28例临床确诊PTSD者和28例年龄性别匹配对照的对照研究，用7天腕式体动记录仪评估睡眠。结果显示，仅在PTSD组中，睡眠效率不规律（标准差）越大，全血超氧化物衡量的氧化应激越高，心迷走压力反射敏感性（cBRS）越低；对照组未见此关联。总睡眠时间规律性及睡眠时长与质量均与上述心血管风险前体指标无关。
PubMed · Rheumatology 系统性红斑狼疮患者疫苗接种与呼吸道感染负担的纵向趋势：一项人群队列研究
一项人群队列研究纳入3,692例系统性红斑狼疮（SLE）患者并与382,753例匹配对照比较，中位随访12.8和13.4年。SLE患者流感、肺炎球菌和COVID-19疫苗接种率均高于对照（77.6%对56.4%、55.6%对32.1%、74.2%对72.0%），但呼吸道住院（34.8%对11.5%）、肺炎住院、ICU入住和全因死亡率更高。
PubMed · PLoS Pathogens 黄热病病毒感染诱导组分独特的应激颗粒组装：机制研究显示其与线粒体损伤相关
体外研究显示，黄热病病毒（YFV）17D疫苗株与Asibi致病株感染后48小时出现翻译 shut-off 和应激颗粒（SG）形成，晚于24小时已出现的感染，可能与衣壳蛋白通过结合G3BP1抑制SG形成有关。
ClinicalTrials.gov API v2 · 登记更新 神经内科：Case-Specific Health Care Professional Clinical Survey of Liberant™ Thrombectomy System
原文摘录：The purpose of Case-Specific Health Care Professional (HCP) Clinical Survey of Liberant™ Thrombectomy System, also known as the Liberant Clinical Assessment, is to collect first-in-human clinical data to confirm the safety and performance of the Medtronic
PubMed · Angewandte Chemie International Edition 外科与麻醉：Rare-Earth Terbium Frustrates Deep Reconstruction of Cobalt Sulfide for Long‑Lived Anion Exchange Membrane Water Electrolysis.
原文摘录：The practical application of metal sulfides in anion-exchange membrane water electrolysis (AEMWE) is fundamentally hindered by the uncontrolled deep reconstruction under anodic conditions, which leads to rapid catalyst deactivation.
PubMed · Stroke 神经内科：How Stroke Genetics Is Impacting Clinical Care: Now and the Future.
原文摘录：The past decade has seen a transformation in our understanding of the genetics of stroke. However, a commonly asked question is how do these advances impact the practicing clinician now, and what are their implications for clinical care in the future?
PubMed · Urology 可膨胀阴茎假体手术感染预防标准化围手术期方案的初步单外科医生回顾性经验
一项回顾性分析2017年1月至2025年12月两家医院单外科医生487例可膨胀阴茎假体（IPP）手术（406例初次植入、58例取出重置、23例部件翻修）的前瞻性维护数据库，采用标准化多模式围手术期感染预防方案，包括MRSA去定植、氯己定洗浴、改良无接触技术、抗生素冲洗和23小时住院观察。
PubMed · Hepatology 临床指南：AASLD EXPO: Diagnosis and management of hepatitis delta virus (HDV) infection.
原文摘录：BACKGROUND: HDV infection represents a rare co-infection or super-infection among persons with HBV infection and is associated with significant morbidity and mortality due to an increased risk of liver events such as hepatic decompensation and HCC. … Recent advances in HDV treatment offer hope for meaningful improvement in clinical outcomes
PubMed · Thrombosis and Haemostasis 天然半胱氨酸变异揭示因子XI二硫键依赖的结构与功能异质性
一项对携新发F11/KLKB1 7-Mb缺失半合子患者中FXI p.Phe295Cys变异的临床、生化和重组表达研究显示，患者为重度FXI缺乏，残留FXI:C活性7%，血浆中存在两种二硫键连接的FXI电泳异质体，突变体特有Cys317、Cys321和Cys193 CAM修饰提示巯基可用性改变。患者接触途径依赖的凝血酶生成受损而组织因子途径保留，无自发出血，预防性处理后顺利接受两次手术。
PubMed · Organic Letters 未保护多肽的后期钯催化硼化方法研究发表于 Organic Letters
研究人员报道了一种对含芳基碘多肽进行后期钯催化硼化的方法，采用预形成的四羟基二硼Lewis碱络合物，减少标准方法中的副产物与副反应。该转化与除半胱氨酸外的所有标准氨基酸残基兼容，并实现了同时含儿茶酚与硼酸的双功能化多肽的动态共价大环化。此为化学方法学研究，作者提出其可用于硼化糖肽动态大环化或经活性氧促进氧化实现活化的多肽药物体系等方向。
PubMed · Pediatric Research 体外研究：BD BACTEC Peds Plus/F 儿童血培养系统对低浓度新生儿败血症常见病原体的检出与阳性时间评估
体外研究将大肠杆菌、无乳链球菌等6种新生儿败血症常见病原体配制成≤1至10-20 CFU/mL的低浓度悬液，接种0.25-2.0 mL至BD BACTEC Peds Plus/F瓶中评估检出率与阳性时间（TTP）。
PubMed · Endocrine Reviews 肿瘤学：Glucagon-like Peptide-1 Receptor Agonists and Thyroid Cancer: Review of Preclinical and Human Data.
原文摘录：Preclinical rodent studies showing a dose-dependent increase in thyroid C-cell hyperplasia and neoplasia with Glucagon-like Peptide-1 Receptor Agonists (GLP-1RAs), led the United States Federal Drug Administration to require a boxed warning contraindicati … Because the preponderance of data does not support a causative relationship between GLP-1RA use and MTC (or PTC), we conclude that the need for the boxed warning about the risk of C-cell neoplasia is no longer necessary
PubMed · Surgical Endoscopy 对照实验评估机器人胆囊切除术中19名外科医生的自动化偏倚与AI提示接受率
一项两阶段对照实验纳入19名外科医生（住院医师10名、专科培训医师2名、主诊医师7名），在机器人胆囊切除术视频静态帧上先无引导、后带模拟AI叠加标记绘制切口线，未使用真实AI模型。
PubMed · Brain 贝叶斯多队列研究分析卒中后抑郁症状的病灶与网络机制
研究团队对来自法国、韩国、德国和美国的四个既往观察性队列共1,864例卒中患者进行贝叶斯体素级再分析，探讨病灶位置与卒中后抑郁症状的关联。结果显示抑郁症状与右额叶病灶及额叶皮层-皮层下环路以右侧为主的结构断连关联最强，并在左半球大部分区域观察到无关联证据；病灶网络映射提示与左侧后扣带回及楔前叶连接相关。研究基于既往队列再分析，属观察性证据。
PubMed · Cell Reports Cell Reports研究：琥珀酸经TCA循环氧化促进多发性骨髓瘤细胞增殖
一项发表于Cell Reports的体外与转录组研究显示，骨髓中升高的TCA循环代谢物琥珀酸可促进多发性骨髓瘤细胞系增殖，其经摄取并在TCA循环中氧化，伴随ATP偶联线粒体呼吸增加及琥珀酸来源碳掺入下游中间代谢物，原代骨髓瘤细胞中也存在此现象；该促增殖依赖线粒体氧化磷酸化，可被ATP合酶抑制消除。大规模转录组数据显示线粒体琥珀酸转运蛋白高表达与疾病进展加速相关，提示其可能成为治疗干预靶点。
PubMed · Cancer Cell Cancer Cell评论：新辅助治疗早期终点研究显示CPS + EG与Neo-Bioscore可预测患者层面而非试验层面长期结局
Cancer Cell本期Conforti等报告，CPS + EG和Neo-Bioscore评分在新辅助治疗中可在患者层面预测长期结局，但在试验层面不能可靠预测，提示需要能跨试验可靠反映疗效的更好早期终点。该评论指出早期终点作为长期结局替代指标对疗效评估的重要性。
WHO · Official News OData 儿科学：WHO at COP31: Health Day opens two weeks of activities to deliver on climate change and health
原文摘录：On Monday, 9 November, health takes centre stage as the thirty-first session of the Conference of the Parties (COP31) to the UN Framework Convention on Climate Change (UNFCCC) opens with a dedicated Health Day. … ATACH and AIR give countries the means to do that, during COP31 and beyond
PubMed · Molecular Cell Molecular Cell 发表机制研究：PARP1 过度活化通过核内 RNA 滞留使转录与蛋白表达解耦联
机制研究显示，人细胞中 APE1 切割无碱基位点驱动 PARP1 过度活化，升高的 PAR 与 RNA 竞争结合多种 RNA 结合蛋白，破坏剪接与核输出并形成 PARP1 依赖的核凝聚体，导致 mRNA 核内滞留、胞质可翻译 mRNA 减少及全局翻译抑制。该过程还阻断多种 DNA 损伤应激因子的 mRNA 核输出而抑制其蛋白表达。研究揭示 PARP1 是 DNA 损伤应答的转录后调控因子。
PubMed · Cancer Research 肿瘤学：Regulatory T Cell Interventions to Boost Anti-tumor Immune Responses.
原文摘录：FOXP3-expressing regulatory T cells (Tregs) are a specialized subset of T lymphocytes that are crucial for maintaining immune homeostasis and preventing autoimmunity.
PubMed · Molecular Biology and Evolution 分子生物学与进化期刊发表模拟研究：出生死亡模型设定错误致Re低估，深度学习校正表现更优
Molecular Biology and Evolution期刊发表的模拟研究（在线2026-11-06）评估系统动力学生痁模型设定错误对平均二代感染数Re和感染时长d推断的影响。结果显示，最简出生死亡模型在存在超级传播、潜伏期或接触者追踪时倾向于低估Re，可能带来公共卫生风险；基于深度学习的复杂模型估计器在这些因素存在或缺失的数据中均表现良好。
PubMed · Cell stem cell 临床前研究：神经接口引导内源性gamma节律调控促进人脑类器官在小鼠损伤视皮层的第4层样重建并改善视觉行为
发表于 Cell Stem Cell 的动物研究显示，在受损成年小鼠视皮层中，以内源性窄带gamma（NBG）节律引导靶向神经调控，可促进移植的人脑类器官（hBO）与宿主的结构和功能整合。移植物出现第4层 appropriate 分子与功能特性，与宿主视觉回路形成双向连接，hBO 神经元出现方向选择性，宿主视觉敏锐度和对比敏感度显著恢复。结果为临床前阶段，尚未在人体验证。
PubMed · Trends in Genetics 行业资料：The trans-acting potential of expanded repeat RNA.
原文摘录：In a subset of repeat expansion disorders, nuclear dysfunction extends beyond the originating locus through poorly understood mechanisms.